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Table 1 Overall and stratified analyses on the association of rs11245007 genotypes with risk of breast cancer in Discovery cohort by multivariate logistic regression model

From: A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women

Genotype

rs11245007 (C/T)

CC

CT

TT

CT + TT

All subjects

    

Cases (n = 1532)

432 (28.20)

738 (48.17)

362 (23.63)

1100 (71.80)

Controls (n = 1573)

443 (28.16)

768 (48.82)

362 (23.01)

1130 (71.84)

Crude OR (95 % CI)

1.00

0.985 (0.834,1.164)

1.025 (0.842, 1.249)

0.998 (0.854, 1.167)

P

 

0.863

0.802

0.982

Adjusted OR (95 % CI)a

1.00

0.796 (0.638,0.992)

0.952 (0.735,1.235)

0.844 (0.687,1.037)

P

 

0.0420

0.7124

0.1069

Parity <3b

    

Cases (n = 1293)

347 (26.84)

636 (49.19)

310 (23.98)

946 (73.16)

Controls (n = 1122)

314 (27.99)

564 (50.27)

244 (21.75)

808 (72.01)

Adjusted OR (95 % CI)a

1.00

0.962 (0.751,1.232)

1.324 (0.987,1775)

1.066 (0.846,1.345)

P

 

0.7605

0.0607

0.5865

Parity ≥3b

    

Cases (n = 188)

67(35.64)

81 (43.09)

40 (21.28)

121 (64.36)

Controls (n = 426)

119 (27.93)

194 (45.54)

113 (26.53)

307 (72.07)

Adjusted OR (95 % CI)a

1.00

0.517 (0.304,0.879)

0.469 (0.251,0.876)

0.499 (0.307,0.813)

P

 

0.0148

0.0175

0.0053

Family history of cancerc

    

Cases (n = 474)

126 (26.58)

238 (50.21)

110 (23.21)

348 (73.42)

Controls (n = 169)

31 (18.34)

95 (56.21)

43 (25.44)

138 (81.66)

Adjusted OR (95 % CI)a

1.00

0.530 (0.299,0.937)

0.592 (0.304,1.151)

0.548 (0.317,0.946)

P

 

0.0289

0.1223

0.0308

No family history of cancerc

    

Cases (n = 1057)

306 (28.95)

500 (47.30)

251 (23.75)

751 (71.05)

Controls (n = 1401)

411 (29.34)

672 (47.97)

318 (22.70)

990 (70.66)

Adjusted OR (95 % CI)a

1.00

0.919 (0.723,1.166)

1.130 (0.854,1.494)

0.985 (0.788,1.230)

P

 

0.4860

0.3933

0.8908

  1. Abbreviations: OR Odds ratios; CI confidence interval
  2. aOR is adjusted for age, BMI, menarche age, parity, time of breast feeding, menopause, oral contraception, smoking status (ever/never), exercise, benign breast disease, and family history of cancer (first- and second-degree relatives)
  3. bdue to missing values, n (total cases with parity data) < 1 532, n (total controls with parity data) < 1 573
  4. cdue to missing values, n (total cases with family history of cancer data) < 1 532, n (total controls with family history of cancer data) < 1 573
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BMC Cancer

ISSN: 1471-2407

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