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Table 3 Distribution of MLH1, MGMT, DAPK-1 methylation according to tumor site and pathological characteristics

From: Gene methylation profile of gastric cancerous tissue according to tumor site in the stomach

 

MLH1 M/U

MGMT M/U

DAPK-1 M/U

Tumor histological parameters

Stomach upper-third cancerous tissue

Stomach middle-third cancerous tissue

Stomach lower-third cancerous tissue

Stomach upper-third cancerous tissue

Stomach middle-third cancerous tissue

Stomach lower-third cancerous tissue

Stomach upper-third cancerous tissue

Stomach middle-third cancerous tissue

Stomach lower-third cancerous tissue

Intestinal type

0/3

6/16

7/10

1/2

5/17

8/11

3/0

12/10

10/7

Diffuse type

1/5

3/14

8/8

1/5

7/10

11/5

1/5

7/10

7/9

p value

0.45

0.48

0.61

0.57

0.22

0.21

0.02

0.41

0.39

T1

0/1

1/2

2/4

0/1

1/2

4/2

1/0

2/1

4/2

T2

0/2

2/2

2/3

0/2

1/3

3/2

1/1

0/4

3/2

T3

0/2

5/11

8/9

1/1

4/12

10/7

1/1

6/10

7/10

T4

1/3

1/15

3/2

1/3

6/10

2/3

1/3

11/5

3/2

p value

0.7

0.17

0.83

0.62

0.88

0.84

0.59

0.06

0.67

N0

0/4

5/9

6/4

2/2

4/10

5/5

3/1

4/10

6/4

N1

0/2

2/4

3/5

0/2

2/4

5/3

0/2

2/4

4/4

N2

0/2

1/6

3/2

0/2

1/6

3/2

1/1

2/5

1/4

N3

1/0

1/11

3/7

0/1

5/7

6/4

0/1

11/1

6/4

p value

0.29

0.33

0.48

0.36

0.66

0.95

0.27

0.01

0.46

  1. M methylated allele, U unmethylated allele