Fig. 3From: The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phaseBCR-ABL/p53 connection, p27 network and miRNAs in CML. BCR-ABL promotes either sequestration of p53 in the cytoplasm through the interaction with IkB-alpha and the p53 degradation through MDM2. Furthermore, the interaction BCR-ABL with p27 is reportedBack to article page