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Table 4 p53 detection analysis

From: Molecular analyses of unselected head and neck cancer cases demonstrates that human papillomavirus transcriptional activity is positively associated with survival and prognosis

Sample ID

Anatomical site

L1 DNA

HPV 16 E6/E7 DNA

HPV 16 mRNA

p53 PCR

Smokers

2

Oropharynx

6

–

–

–

+

5

Larynx

16

–

–

–

–

7

Hypopharynx

–

–

–

–

+

8

Other

–

–

–

–

+

9

Oropharynx

6, 16

–

–

–

+

12

Other

6, 11

–

–

–

–

17

Oropharynx

Mixed

–

–

–

+

18

Larynx

–

–

–

–

+

26

Larynx

6

–

–

+

–

39

Oropharynx

16

–

–

+

–

50

Oropharynx

16

+

–

–

+

52

Hypopharynx

16

+

–

–

–

10

Larynx

6

–

+

–

–

14

Larynx

–

–

+

–

+

15

Larynx

–

+

+

–

–

16

Oral cavity

40

–

+

+

–

33

Larynx

16

+

+

+

+

35

Hypopharynx

16

–

+

+

–

36

Larynx

16

+

+

+

+

41

Oropharynx

16, mixed

+

+

+

–

54

Larynx

–

–

+

+

–

  1. Amplicons spanning the entire p53 open reading frame were amplified from 6/9 HPV 16 E6/E7 mRNA positive HNSCCs (bottom), but only 2/12 transcript negative samples (top) (p = 0.032, Fisher’s exact test; OR 10). HPV16 DNA or P16INK4a showed no relationship with p53 PCR