Fig. 2From: Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevanceFrequencies of VHL LOF (loss of function; blue) and missense mutations (cyan), mutation sites and affected binding domains of pVHL’s interactors. Note: the first 162 base pairs (54 amino acids) were not sequencedBack to article page