Skip to main content
  • Research article
  • Open access
  • Published:

Belotecan/cisplatin versus etoposide/cisplatin in previously untreated patients with extensive-stage small cell lung carcinoma: a multi-center randomized phase III trial

Abstract

Background

No novel chemotherapeutic combinations have demonstrated superior efficacy to etoposide/cisplatin (EP), a standard treatment regimen for extensive-stage small cell lung carcinoma (ES-SCLC) over the past decade. We aimed to compare the efficacy and safety of belotecan/cisplatin (BP) and EP regimens in chemotherapy- and radiotherapy-naïve patients with previously untreated ES-SCLC.

Methods

We conducted a multi-center, randomized, open-label, parallel-group, phase III clinical study. A total of 157 patients were recruited at 14 centers with 147 patients meeting the inclusion/exclusion criteria and randomized to either BP (n = 71) or EP (n = 76) treatment arms. A non-inferior response rate (RR) in the BP arm, analyzed by intent-to-treat analysis according to Response Evaluation Criteria in Solid Tumors version 1.0 criteria, was used as the primary endpoint. The secondary endpoints were progression-free survival (PFS) and overall survival (OS).

Results

In the BP arm, one patient had a complete response, 41 had a partial response (PR), and 17 had stable disease (SD). In the EP arm, 35 patients had PR and 28 had SD. The RR in the BP arm was non-inferior to the EP regimen in patients with ES-SCLC (BP: 59.2 %, EP: 46.1 %, difference: 13.1 %, 90 % two-sided confidence interval: -0.3–26.5, meeting the predefined non-inferiority criterion of -15.0 %). No significant differences in OS or PFS were observed between the treatment arms. Hematologic toxicities, including grade 3/4 anemia and thrombocytopenia, were significantly more prevalent in the BP arm than the EP arm.

Conclusions

The RR to the BP regimen was non-inferior to the EP regimen in chemotherapy- and radiotherapy-naïve patients with previously untreated ES-SCLC. Hematologic toxicities were significantly more prevalent in the BP group, indicating that BP should be used with care, particularly in patients with a poor performance status. Further studies assessing PFS and OS are required to validate the superiority of the BP regimen.

Trial registration

ClinicalTrials.gov identifier NCT00826644. Date of Registration: January 21, 2009.

Peer Review reports

Background

Lung cancer is one of the leading causes of cancer-related death worldwide [13]. Small cell lung cancer (SCLC) accounts for up to 20 % of all new cases of lung cancer and deaths [3, 4]. Compared to non-small cell lung cancer (NSCLC), SCLC is generally more aggressive, with decreased doubling times and faster growth rates. Moreover, early widespread metastasis is a recognized feature of SCLC [5]. Extensive-stage SCLC (ES-SCLC) refers to SCLC metastasis to distant body regions. Since the mid-1980s, no significant improvement in the survival of patients with ES-SCLC has been observed; the median overall survival (OS) is estimated at approximately 10 months [610]. Currently, a two-drug combination of platinum and etoposide at doses associated with at least moderate toxic effects is most commonly used to treat ES-SCLC [11]. The overall response rates of 50 %–80 % and complete response rates of 0 %–30 % have been reported with this treatment approach [12, 13].

To date, a number of pharmacological agents have been developed for the treatment of NSCLC. However, no novel chemotherapeutic combinations have demonstrated superior efficacy to etoposide/cisplatin (EP), a standard treatment regimen, in the treatment of SCLC over the past decade, although irinotecan/cisplatin (IP) has been reported as an effective combination regimen [10]. Belotecan {7-[2(N-isopropylamino) ethyl]-(20S)-camptothecin} is a newly developed camptothecin analogue. According to two multi-center phase IIa studies, belotecan monotherapy is an effective modality for the treatment of SCLC in chemotherapy-naïve patients [14, 15]. Moreover, multi-center phase II studies have reported response rates (RR) higher than 70 % and OS greater than 10 months in patients with ES-SCLC receiving belotecan/cisplatin (BP) as a first-line treatment regimen [1618].

On the basis of the above mentioned information, we conducted a multi-center, randomized, open-label, parallel-group, phase III clinical study to compare the efficacy and safety of BP and EP regimens in chemotherapy- and radiotherapy-naïve patients with previously untreated ES-SCLC.

Methods

Study patients

Patients who met all of the following inclusion criteria were enrolled in this trial: (1) aged between 19 and 80 years, (2) histologically or cytologically proven ES-SCLC, (3) no past history of chemotherapy or radiotherapy, (4) ≥1 measurable disease according to the Response Evaluation Criteria in Solid Tumors (RECIST) criteria version 1.0, (5) Eastern Cooperative Oncology Group (ECOG) performance status (PS) of ≤2, (6) a life expectancy of ≥12 weeks, (7) adequate organ function [absolute neutrophil count (ANC) ≥1,500/mm3, platelet count ≥100,000/mm3, hemoglobin ≥9.0 g/dL, total bilirubin level ≤1.5 mg/dL, aminotransferase ≤2-fold upper limit of normal (ULN) or ≤3-fold ULN if demonstrable liver metastases, alkaline phosphatase ≤2-fold ULN, and creatinine ≤1.5 mg/dL or creatinine clearance ≥60 mL/min].

The exclusion criteria were as follows: (1) severe bacterial infection, (2) malignancies other than basal cell skin cancer or cervical carcinoma in situ, (3) brain metastases, (4) women with child-bearing potential, and (5) women who are pregnant or breast-feeding.

The study was approved by the Institutional Review Board (IRB) of each medical institution. All patients provided a written informed consent. The current study was registered with ClinicalTrials.gov (Identifier: NCT00826644).

Dosing rationale and schedule

Patients were randomized to either EP or BP treatment arms and stratified according to ECOG PS (0-1 vs. 2) and age (<65 vs. ≥65 years) at a ratio of 1:1. A phase I study was conducted to determine the maximum tolerated dose (MTD), toxicity, and dose-limiting toxicity of BP; it showed that the MTD and recommended dose for phase II studies was 0.5 mg/m2 on days 1–4 in combination with 60 mg/m2 cisplatin on day 1 at a 3-week interval [19]. The BP regimen consisted of intravenous belotecan 0.5 mg/m2 mixed with 100 mL of 5 % dextrose over 30 min on day 1–4 and intravenous cisplatin 60 mg/m2 on day 1 of 3-week cycles. The EP regimen consisted of etoposide 100 mg/m2 on days 1, 2 and 3 and cisplatin 60 mg/m2 on day 1 of 3-week cycles. Both regimens required hydration and administration of antiemetic drugs.

On day 1, the patients were treated if they showed an ANC ≥1,500/mm3, platelet count ≥100,000/mm3, and creatinine clearance ≥60 mL/min. In addition, the patients were given recombinant human granulocyte colony-stimulating factor (G-CSF) to improve ANC according to clinical judgment. Subsequent treatments were delayed on a weekly basis until recovery of ANC in cases of G-CSF treatment failure. The patients dropped out of the study if the treatment was delayed by more than 2 weeks. With respect to the dose of the subsequent treatment, the patients were given unadjusted treatment doses upon recovery of ANC to ≥1,500/mm3 and a platelet count ≥100,000/mm3. In the patients achieving a recovery of ANC to 1,000–1,500/mm3 and a platelet count to 75,000–100,000/mm3, subsequent treatment doses were reduced by 20 %. In patients with ANC <500/mm3, platelet count <25,000/mm3, or febrile neutropenia during treatment, subsequent treatment doses were reduced by 20 %. Cisplatin doses were not adjusted in patients with decreases in creatine clearance to ≥60 mL/min from baseline. Cisplatin doses were reduced by 50 % in patients with creatinine clearance of 30–60 mL/min. Cisplatin was discontinued in patients with decreases in creatinine clearance to ≤30 mL/min.

Patient evaluation

The patients were evaluated at baseline based on their medical history, physical examination, imaging studies, complete blood counts, and serum biochemistry. The response was assessed by computed tomography (CT) every two treatment cycles at follow-up visits. After the completion of chemotherapy, CT scans were performed every three months until evidence or suspicion of disease progression. The treatment response was centrally evaluated independently according to RECIST version 1.0 criteria as follows: (1) complete response (CR), disappearance of all clinical and radiological evidence of the tumor; (2) partial response (PR), decrease of 30 % or more in the sum of longest diameters of all target measurable lesions; (3) progressive disease (PD), increase of more than 20 % of the sum of longest diameters of all target measurable lesions or the appearance of new lesions; and (4) stable disease (SD), all other circumstances. The patients eligible for response evaluation were evaluated at a minimum interval of 4 weeks to confirm CR or PR. Adverse events (AEs) were graded according to the NCI-CTCAE, version 3.0 (http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcaev3.pdf).

Efficacy endpoints

Per-protocol (PP) population was defined patients who completed two cycles of chemotherapy in accordance with the protocol. Modified Intent-to-treat (mITT) population was defined as patients randomized and treated with at least one cycle of chemotherapy. mITT analysis was used to assess non-inferiority of RR in the BP arm as the primary endpoint according to RECIST 1.0 criteria. The secondary endpoints were progression-free survival (PFS) and OS. Subgroup analysis of the mITT population was performed to assess the associations between RR and ECOG PS, age, and body weight.

Safety endpoints

The safety population comprised all patients eligible for safety analysis. The occurrence of toxicities and adverse effects were evaluated throughout the study period through the measurement of vital signs, physical examination, and clinical laboratory tests. The safety endpoints were adverse drug reactions (ADRs), serious adverse events (SAEs), and treatment-related death (TRD).

Statistical analyses

To determine the sample size, we estimated an RR of 71 % for the BP arm [14, 15, 19] and 66 % for the EP arm [6, 13, 20], considering a non-inferiority margin of −15 % at a power of 80 % with a one-sided error (α) = 0.05 [21]. In addition, we assumed a dropout rate of 10 % during the follow-up period. Thus, we aimed to enroll a total of 150 patients (n = 150) in the present study.

The baseline and clinical characteristics of the patients were expressed as median and range. The Student’s t-test and chi-square test were used to compare two treatment arms, as appropriate. Two-sided 90 % confidence intervals (CIs) were calculated for the difference in the RR between the two treatment arms without corrections for continuity, as described by Newcombe [21]. The Cochran–Mantel–Haenszel (CMH) test was performed in patients who met the criteria for non-inferiority with consideration of the stratification factors. Thus, we attempted to analyze the difference in RR between the two treatment arms using Fisher’s exact test. PFS was defined as the time from randomization to clinical or radiological progression or death. OS was defined as the time from randomization to death from any cause. If the patient was lost to follow up or an event (disease progression or death) did not occur until study termination, the patient was censored at the time of last contact. PFS and OS were analyzed using the Kaplan–Meier methods.

Results

Patient groups

A total of 157 patients were recruited at 14 centers across Korea from January 2009 to January 2013. Of these, 147 patients met the inclusion/exclusion criteria of this study and were randomized to the BP (n = 71) or EP (n = 76) arms. The number of the patients in the mITT, PP, and safety populations were 71, 57, and 70 in the BP arm and 76, 63, and 77 in the EP arm, respectively (Fig. 1).

Fig. 1
figure 1

Disposition of the study patients. Of the 157 patients we recruited at a total of 14 centers, 147 met inclusion/exclusion criteria and then randomized to either the BP arm (n = 71) or the EP arm (n = 76). In the BP arm, the number of the patients of the mITT set, the PP set and the safety set were 71, 57 and 70, respectively. In the EP arm, these values were 76, 63 and 77 in the corresponding order

Patient baseline and clinical characteristics

No significant differences in the median age, median male-to-female ratio, median body surface area, or median ECOG PS were observed between the treatment arms (Table 1). A significant difference in the median body mass index was observed between the treatment arms (p < 0.05).

Table 1 Patient demographics of modified intent-to-treat population

The proportion of the patients receiving more than four cycles of chemotherapy was 67.1 % in the BP arm and 63.7 % in the EP arm. The mean number of chemotherapy cycles was 3.9 in the BP arm and 4.1 in the EP arm. In the BP arm, the mean delivered dose of belotecan and cisplatin was 0.45 mg/m2 (90.0 % of planned dose) and 56.8 mg/m2 (94.6 % of planned dose), respectively. In the EP arm, the mean delivered dose of etoposide and cisplatin was 93.8 mg/m2 (93.8 % of planned dose) and 58.6 mg/m2 (97.7 % of planned dose), respectively. The relative dose intensity (RDI) was calculated by dividing the intensity of the delivered dose by that of the standard dose. A significantly lower RDI was observed in the BP arm than that in the EP arm (0.79 ± 0.14 vs. 0.86 ± 0.13, p = 0.001).

Efficacy endpoints

Response rates

According to the mITT analysis, the RR was 59.2 % in the BP arm and 46.1 % in the EP arm (Table 2 & Fig. 2). The lower limit of the two-sided 90 % CI was greater than the non-inferiority margin (−0.3 vs. −15.0). This indicates that the BP regimen was non-inferior to the EP regimen with respect to the RR in patients with ES-SCLC.

Table 2 Best overall response of modified intent-to-treat and per protocol population
Fig. 2
figure 2

Efficacy endpoints of modified intent-to-treat (mITT) and per protocol (PP) population. The BP group is not inferior to the EP group with regards to the response rate (between group difference 13.1 %, 90 % two-sided confidence interval -0.3 to 26.5, meeting the predefined non-inferiority criterion of -15.0 %) in mITT population. The response of the BP group was superior in PP population

According to the PP analysis, an 18.0 % difference in the RR was demonstrated between the two treatment arms (90 % CI: 3.7–32.3). In addition, no significant differences in the RRs between the two treatment arms in either the mITT or PP groups were observed according to the CMH test.

Overall survival and progression-free survival

No significant differences in OS or PFS were observed between the treatment arms. The median OS was 360 days (95 % CI: 285–482) in the BP arm and 305 days (95 % CI: 232–343) in the EP arm (Log-Rank p = 0.210, Fig. 3). In addition, the median PFS was 190 days (95 % CI: 148–219) in the BP arm and 172 days (95 % CI: 144–195) in the EP arm (Log-Rank p = 0.369, Fig. 3).

Fig. 3
figure 3

Overall survival and progression-free survival on Kaplan–Meier analysis. (a) There were no significant differences in the OS and PFS between the two treatment arms. That is, the median OS was 360 days (95 % CI: 285–482) in the BP arm and 305 days (95 % CI: 232–343) in the EP arm (Log-Rank p = 0.210). (b) The median PFS was 190 days (95 % CI: 148-219) in the BP arm and 172 days (95 % CI: 144–195) in the EP arm (Log-Rank p = 0.369)

Subgroup analysis

In the BP arm, the RR was 63.3 % in patients with ECOG PS 0-1 (n = 60) and 36.4 % in those with ECOG PS 2 (n = 11). In the EP arm, the RR was 52.7 % in patients with ECOG PS 0–1 (n = 55) and 28.6 % in those with ECOG PS 2 (n = 21). In addition, the RR was 66.7 % in patients aged ≤65 years (n = 30) and 53.7 % in those aged ≥65 years (n = 41) in the BP arm. In the EP arm, the RR was 57.8 % in patients aged ≤65 years (n = 33) and 37.2 % in those aged ≥65 years (n = 43). Furthermore, the RR was 60.0 % in patients weighing less than 62.5 kg (n = 30) and 58.5 % in those weighing more than 62.5 kg (n = 41) in the BP arm. In the EP arm, the RR was 45.2 % in patients weighing less than 62.5 kg (n = 42) and 47.1 % in those weighing more than 62.5 kg (n = 34).

Safety endpoints

In the present study, all 147 included patients were eligible for safety analysis. No significant differences in ADRs or TRD were observed between the treatment arms (98.6 % vs. 92.2 %, p = 0.119 and 12.9 % vs. 10.4 %, p = 0.797, respectively). However, the incidence of SAEs was significantly higher in the BP arm (42/70 cases, 60.0 %) than those in the EP arm (31/77 cases, 40.3 %, p = 0.021). Hematologic toxicities were more prevalent in this study than non-hematologic toxicities. Grade 3/4 anemia (34.3 %) and thrombocytopenia (54.3 %) were significantly more prevalent in the BP arm than those in the EP arm. No significant difference in the incidence of non-hematologic toxicities was observed between the treatment arms. Grade 3/4 infection and hyponatremia occurred in approximately 10 % of the patients in both treatment arms. Nearly all the non-hematologic toxicities were of grade 1/2 severity and could be treated successfully (Table 3).

Table 3 Hematologic and non-hematologic toxicities of safety population

Discussion

This is the first study to evaluate the non-inferiority of the BP regimen compared to the EP regimen as a first-line treatment in patients with previously untreated ES-SCLC. Compared to the EP regimen, the RR of the BP regimen was non-inferior in the mITT population and better in the PP population. Grade 3/4 anemia and thrombocytopenia were more prevalent in the BP arm than those in the EP arm. In addition, the RDI was significantly lower in the BP arm than that in the EP arm. However, no significant differences in OS or PFS were observed between the treatment arms.

Over recent decades, EP has been considered the gold-standard treatment for ES-SCLC. In 2002, a phase III trial was conducted by the Japan Clinical Oncology Group; it demonstrated the superiority of IP over EP in patients with ES-SCLC [10]. However, two subsequent randomized phase III trials failed to confirm the superiority of IP over EP in North American and Australian populations [7, 8]. Noda et al. reported that the RR and median OS were 65 % and 12.8 months in the IP arm, respectively [10]. Our results were consistent with previous studies, demonstrating a similar efficacy based on an RR of 60 % and a median OS of 12.9 months. However, we found a higher proportion of patients with ECOG PS 2 than the study by Noda et al. (16 % vs. 8 %). Moreover, the RR in the present study was approximately 10 % lower than previous phase II trials enrolling a smaller number of patients [1618]. To date, Lim et al. have reported the highest RR (73.8 %) with the use of the BP regimen [18]. Lee et al. reported a median PFS of 6.9 months and a median OS of 19.2 months in patients receiving the BP regimen [16]. In the current study, the degree of the difference in the RR between the two treatment arms was higher in the PP population than the mITT population (18.0 % vs. 13.1 %). Moreover, our results also showed a slightly higher RR in patients with ECOG PS 0–1 (63.3 %) and those aged ≤65 years (66.7 %). These results indicate that the BP regimen may have a greater utility in younger patients with a good performance status.

In the present study, favorable rates of non-hematologic toxicities were observed in the BP arm according to the safety analysis. We found that 2.9 % of the patients in the BP arm developed grade 3/4 diarrhea; this may be considerably lower than the incidence of non-hematologic toxicities reported in the IP arm of previous trials (16 %–19 %) [8, 10]. In the BP arm, neutropenia was one of the most frequent hematologic toxicities, 77 % of which were of grade 3 or 4 severity. Grade 3/4 febrile neutropenia occurred in 15.7 % of patients in the BP arm. Of these, one patient died of pneumonia. No significant differences in the incidences of neutropenia or febrile neutropenia were observed between the treatment arms. In the EP arm, there were five cases of treatment-related deaths due to pneumonia or sepsis. However, grade 3/4 anemia (34.3 % vs. 13.0 %, p = 0.003) and thrombocytopenia (54.3 % vs. 16.9 %, p < 0.001) were significantly more prevalent in the BP arm than the EP arm. The prophylactic use of G-CSF or 5 %–10 % reductions in chemotherapeutic doses may be considered to prevent hematologic toxicities. In the present study, the mean RDI was 7 % lower in the BP arm than that in the EP arm (0.79 ± 0.14 vs. 0.86 ± 0.13). A previous phase II study found that more than half of the patients presented with grade 4 neutropenia and reported an RDI of 70.1 % in the belotecan regimen and 83.0 % in the cisplatin regimen. As a result of the findings of this trial, the recommended BP regimen dose of BP was reduced by 25 % (0.5 mg/m2 for 3 days) [17].

A first limitation of this study is the non-inferiority design of this trial. Because the experimental arm demonstrated a higher hematological toxicity, superior results are required to justify the use of the experimental treatment. Because the analysis of the PP group demonstrated a better response rate with the BP regimen than the EP regimen, further studies are required to validate the superior efficacy of the BP regimen. Second limitation is the significance level in the statistical design. Although setting the significance level for one-sided, non-inferiority trials is recommended at 0.025, we chose the alpha level at 0.05 to accomplish the trial within reasonable time span. Third, the ORR which was primary endpoint of this study may not be sufficiently correlated to patient’s outcome. We selected ORR instead of OS because this study was conducted with small sample size. Fourth, the ITT set of this study was mITT population as 9 randomized patients are excluded because they did not receive the randomly assigned regimen. They were three subjects who withdrew informed consents and six who did not meet inclusion criteria. If a subject who actually did not receive any treatment is included as a subject who received treatment, then it indicates very little about the efficacy of the treatment [22]. So we defined mITT population as patients randomized and treated with at least one cycle of chemotherapy. Fifth, the interpretation of subgroup analyses for ECOG PS score, age and body weight was limited because of the issue of multiple comparisons. Finally, as the open-label nature of this study could be regarded as a flaw in a non-inferiority study. However, because these two regimens have different infusion protocols, we were unable to design this study as a blinded trial.

Conclusions

The results of this trial indicate that the RR with the BP regimen is non-inferior to the EP regimen in chemotherapy- and radiotherapy-naïve patients with previously untreated ES-SCLC. However, hematologic toxicities, including anemia and thrombocytopenia, were more prevalent in the BP arm. These findings strongly suggest that clinicians should be careful in prescribing the BP regimen to elderly patients or those with a poor performance status for the purpose of preventing hematologic toxicities. Further studies evaluating PFS and OS are required to validate the superiority of the BP regimen.

Abbreviations

ADR:

Adverse drug reactions

AEs:

Adverse events

ANC:

Absolute neutrophil counts

BP:

Belotecan and cisplatin

CI:

Confidence interval

CMH:

Cochran-mantel-haenzel

CR:

Complete response

ECOG:

Eastern cooperative oncology group

EP:

Etoposide and cisplatin

ES-SCLC:

Extensive-stage small cell lung cancer

G-CSF:

Granulocyte colony-stimulating factor

HR:

Hazards ratio

IP:

Irinotecan and cisplatin

IRB:

Institutional review board

mITT:

Modified intent-to-treat

MTD:

Maximum tolerated dose

NSCLC:

Non-small cell lung cancer

OS:

Overall survival

PD:

Progressive disease

PFS:

Progression-free survival

PP:

Per-protocol

PR:

Partial response

PS:

Performance status

RDI:

Relative dose-intensity

RECIST:

Response evaluation criteria in solid tumors

RR:

Response rate

SAE:

Serious adverse events

SCLC:

Small cell lung cancer

SD:

Stable disease

TRD:

Treatment-related death

ULN:

Upper limit of normal

References

  1. Dela Cruz CS, Tanoue LT, Matthay RA. Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med. 2011;32(4):605–44.

    Article  PubMed  Google Scholar 

  2. Youlden DR, Cramb SM, Baade PD. The International Epidemiology of Lung Cancer: geographical distribution and secular trends. J Thorac Oncol. 2008;3(8):819–31.

    Article  PubMed  Google Scholar 

  3. In KH, Kwon YS, Oh IJ, Kim KS, Jung MH, Lee KH, Kim SY, Ryu JS, Lee SY, Jeong ET, et al. Lung cancer patients who are asymptomatic at diagnosis show favorable prognosis: a korean Lung Cancer Registry Study. Lung Cancer. 2009;64(2):232–7.

    Article  PubMed  Google Scholar 

  4. Govindan R, Page N, Morgensztern D, Read W, Tierney R, Vlahiotis A, Spitznagel EL, Piccirillo J. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol. 2006;24(28):4539–44.

    Article  PubMed  Google Scholar 

  5. Jackman DM, Johnson BE. Small-cell lung cancer. Lancet. 2005;366(9494):1385–96.

    Article  CAS  PubMed  Google Scholar 

  6. Eckardt JR, von Pawel J, Papai Z, Tomova A, Tzekova V, Crofts TE, Brannon S, Wissel P, Ross G. Open-label, multicenter, randomized, phase III study comparing oral topotecan/cisplatin versus etoposide/cisplatin as treatment for chemotherapy-naive patients with extensive-disease small-cell lung cancer. J Clin Oncol. 2006;24(13):2044–51.

    Article  CAS  PubMed  Google Scholar 

  7. Hanna N, Bunn Jr PA, Langer C, Einhorn L, Guthrie Jr T, Beck T, Ansari R, Ellis P, Byrne M, Morrison M, et al. Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer. J Clin Oncol. 2006;24(13):2038–43.

    Article  CAS  PubMed  Google Scholar 

  8. Lara Jr PN, Natale R, Crowley J, Lenz HJ, Redman MW, Carleton JE, Jett J, Langer CJ, Kuebler JP, Dakhil SR, et al. Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124. J Clin Oncol. 2009;27(15):2530–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Spigel DR, Townley PM, Waterhouse DM, Fang L, Adiguzel I, Huang JE, Karlin DA, Faoro L, Scappaticci FA, Socinski MA. Randomized phase II study of bevacizumab in combination with chemotherapy in previously untreated extensive-stage small-cell lung cancer: results from the SALUTE trial. J Clin Oncol. 2011;29(16):2215–22.

    Article  CAS  PubMed  Google Scholar 

  10. Noda K, Nishiwaki Y, Kawahara M, Negoro S, Sugiura T, Yokoyama A, Fukuoka M, Mori K, Watanabe K, Tamura T, et al. Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med. 2002;346(2):85–91.

    Article  CAS  PubMed  Google Scholar 

  11. Okamoto H, Watanabe K, Kunikane H, Yokoyama A, Kudoh S, Asakawa T, Shibata T, Kunitoh H, Tamura T, Saijo N. Randomised phase III trial of carboplatin plus etoposide vs split doses of cisplatin plus etoposide in elderly or poor-risk patients with extensive disease small-cell lung cancer: JCOG 9702. Br J Cancer. 2007;97(2):162–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Pujol JL, Carestia L, Daures JP. Is there a case for cisplatin in the treatment of small-cell lung cancer? A meta-analysis of randomized trials of a cisplatin-containing regimen versus a regimen without this alkylating agent. Br J Cancer. 2000;83(1):8–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Roth BJ, Johnson DH, Einhorn LH, Schacter LP, Cherng NC, Cohen HJ, Crawford J, Randolph JA, Goodlow JL, Broun GO, et al. Randomized study of cyclophosphamide, doxorubicin, and vincristine versus etoposide and cisplatin versus alternation of these two regimens in extensive small-cell lung cancer: a phase III trial of the Southeastern Cancer Study Group. J Clin Oncol. 1992;10(2):282–91.

    Article  CAS  PubMed  Google Scholar 

  14. Lee DH, Kim SW, Suh C, Lee JS, Lee JH, Lee SJ, Ryoo BY, Park K, Kim JS, Heo DS, et al. Belotecan, new camptothecin analogue, is active in patients with small-cell lung cancer: results of a multicenter early phase II study. Ann Oncol. 2008;19(1):123–7.

    Article  CAS  PubMed  Google Scholar 

  15. Kim SJ, Kim JS, Kim SC, Kim YK, Kang JY, Yoon HK, Song JS, Lee SH, Moon HS, Kim JW, et al. A multicenter phase II study of belotecan, new camptothecin analogue, in patients with previously untreated extensive stage disease small cell lung cancer. Lung Cancer. 2010;68(3):446–9.

    Article  CAS  PubMed  Google Scholar 

  16. Lee DH, Kim SW, Suh C, Lee JS, Ahn JS, Ahn MJ, Park K, Na II, Lee JC, Ryoo BY, et al. Multicenter phase 2 study of belotecan, a new camptothecin analog, and cisplatin for chemotherapy-naive patients with extensive-disease small cell lung cancer. Cancer. 2010;116(1):132–6.

    CAS  PubMed  Google Scholar 

  17. Hong J, Jung M, Kim YJ, Sym SJ, Kyung SY, Park J, Lee SP, Park JW, Cho EK, Jeong SH, et al. Phase II study of combined belotecan and cisplatin as first-line chemotherapy in patients with extensive disease of small cell lung cancer. Cancer Chemother Pharmacol. 2012;69(1):215–20.

    Article  CAS  PubMed  Google Scholar 

  18. Lim S, Cho BC, Jung JY, Kim GM, Kim SH, Kim HR, Kim HS, Lim SM, Park JS, Lee JH, et al. Phase II study of camtobell inj. (belotecan) in combination with cisplatin in patients with previously untreated, extensive stage small cell lung cancer. Lung Cancer. 2013;80(3):313–8.

    Article  PubMed  Google Scholar 

  19. Lee DH, Kim SW, Bae KS, Hong JS, Suh C, Kang YK, Lee JS. A phase I and pharmacologic study of belotecan in combination with cisplatin in patients with previously untreated extensive-stage disease small cell lung cancer. Clin Cancer Res. 2007;13(20):6182–6.

    Article  CAS  PubMed  Google Scholar 

  20. Artal-Cortes A, Gomez-Codina J, Gonzalez-Larriba JL, Barneto I, Carrato A, Isla D, Camps C, Garcia-Giron C, Font A, Meana A, et al. Prospective randomized phase III trial of etoposide/cisplatin versus high-dose epirubicin/cisplatin in small-cell lung cancer. Clin Lung Cancer. 2004;6(3):175–83.

    Article  CAS  PubMed  Google Scholar 

  21. Newcombe RG, Bender R. Implementing GRADE: calculating the risk difference from the baseline risk and the relative risk. Evid Based Med. 2014;19(1):6–8.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Gupta SK. Intention-to-treat concept: A review. Perspect Clin Res. 2011;2(3):109–12.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

We are grateful for the patients, investigators and institutions involved in the current study. The current study was conducted in the following institutions: Konkuk University Medical Center (Kye-Young Lee and Hee-Joung Kim), Korea University Medical Center (Kwang-Ho In, Se-Hwa Yoo, Sang-Yeub Lee, Sung Yong Lee, Hye-Ock Kim, and Kyoung-Ju Lee), Kosin University Gospel Hospital (Tae-Won Jang, Man-Hong Jung, and Chul-Ho Ok), Daegu Catholic University Medical Center (Kyung-Chan Kim), Dongnam Institute of Radiological and Medical Science (Sun-Hyo Park), Soonchunhyang University Cheonan Hospital (Jae-Sung Choi, Young-Hun Kim, Ki-Hyun Seo, Ju-Ock Na, and Ho-Sung Lee), Yonsei University Wonju Severance Christian Hospital (Kye-Chul Shin, Suk-Joong Yong, Won-Yeon Lee, and Joung-Hwan Kim), Yeungnam University Medical Center (Kwan Ho Lee, and Jin-Hong Chung), Wonkwang University Hospital (Sei-Hoon Yang), Inje University Busan Paik Hospital (Hyun-Kyung Lee and Young-Min Lee), Chungnam National University Hospital and Cancer Institute (Sun Young Kim, Hee-Sun Park, and Jeong Eun Lee), Hallym University Sacred Heart Hospital (Seung-Hun Jang and Yong-Il Hwang) and Chonnam National University Hwasun Hospital (Young-Chul Kim, Kyu-Sik Kim, and In-Jae Oh).

Funding

The current study was financially supported by the Chong Kun Dang Pharmaceutical Corp. (Seoul, Korea). But the funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Availability of data and materials

Identifying/confidential patient data should not be shared.

Authors’ contributions

IJO and YCK conceived of the study, participated in its design and coordination, contributed to the acquisition, analysis and interpretation of data and drafted the manuscript. KSK and CKP conceived of the study, participated in its design and coordination, contributed to the acquisition, analysis and interpretation of data. KHL, JHC, SYK, JEL, KCS, TWJ, HKL, KYL and SYL conceived of the study, participated in its design and coordination and contributed to the acquisition. All authors contributed to and approved the final version of the manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Not applicable.

Ethics approval and consent to participate

The protocol and all recruiting materials and consent form have been approved by the Institutional Review Board (IRB) at the Chonnam National University Hwasun Hospital (IRB No. HCRI 08-010-3). All changes to the protocol and recruiting materials are continuously reviewed and approved at each IRBs of 13 centers across Korea including Konkuk University Medical Center, Korea University Medical Center, Kosin University Gospel Hospital, Daegu Catholic University Medical Center, Dongnam Institute of Radiological and Medical Science, Soonchunhyang University Cheonan Hospital, Yonsei University Wonju Severance Christian Hospital, Yeungnam University Medical Center, Wonkwang University Hospital, Inje University Busan Paik Hospital, Chungnam National University Hospital and Cancer Institute and Hallym University Sacred Heart Hospital. All participants from each institutions provided written informed consent.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Young-Chul Kim.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Oh, IJ., Kim, KS., Park, CK. et al. Belotecan/cisplatin versus etoposide/cisplatin in previously untreated patients with extensive-stage small cell lung carcinoma: a multi-center randomized phase III trial. BMC Cancer 16, 690 (2016). https://0-doi-org.brum.beds.ac.uk/10.1186/s12885-016-2741-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://0-doi-org.brum.beds.ac.uk/10.1186/s12885-016-2741-z

Keywords