Body mass index modifies the relationship between γ-H2AX, a DNA damage biomarker, and pathological complete response in triple-negative breast cancer

Table 5 Uni- and multivariate logistic regression models of patient- and disease-related features and pCR upon adjustment of the multivariate model for Ki-67, γ-H2AX and pChk1 (N = 54)

	BMI < 25
	Univariate logistic regression			Multivariate logistic regression^a
	OR	95%CI	p-value	OR	95%CI	p-value
Stage
III vs II	0.37	0.08–1.81	0.220
Grade
3 vs 1–2	0.98	0.23–4.25	0.981
Ki67
High vs Low	0.19	0.04–0.97	0.046	0.30	0.04–2.06	0.223
γ-H2AX
High vs Low	10.83	1.79–65.55	0.009	6.34	0.89–45.33	0.066
pChk1
Pos vs Neg	7.50	1.47–38.28	0.015	4.82	0.77–30.26	0.093
	BMI ≥ 25
	Univariate logistic regression			Multivariate logistic regression
	OR	95%CI	p-value	OR	95%CI	p-value
Stage
III vs II	0.65	0.06–7.32	0.727
Grade
3 vs 1–2	3.00	0.39–23.07	0.291
Ki-67
High vs Low	0.25	0.02–2.70	0.253
γ-H2AX
High vs Low	1.05	0.14–7.93	0.964
pChk1
Pos vs Neg	Not applicable

ISSN: 1471-2407