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Fig. 6 | BMC Cancer

Fig. 6

From: Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma

Fig. 6

AZ and/or MS-275 treatments increase the apoptotic TUNEL index in NB xenografts. a-b present ultrastructural details [x5000, cytoplasmic (arrow)] including the percentage of pyknotic cells. c-d present results from the TUNEL assay (x20 and x40) for detection of apoptotic cells (arrow) and the number of apoptotic positive cells after 14 days treatment with AZ, MS-275 and AZ + MS-275 compared to untreated group in SH-SY5Y xenografts. The number of TUNEL positive cells increased modestly after treatment with AZ (7 ± 0.66%; p = 0.0015), moderately after MS-275 (56 ± 0.33%; p < 0.001) and significantly after AZ + MS-275 (82 ± 76%; p < 0.001) compared to the untreated group. e-f present the expression of the apoptotic marker (cleaved PARP) that was significantly induced by AZ (12% ± 0.16%; p = 0.001), MS-275 (63% ± 0.33%; p = 0.0001) and further by AZ + MS-275 (78% ± 0.09%; p = 0.0001)

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