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Fig. 2 | BMC Cancer

Fig. 2

From: Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway

Fig. 2

Wogonin induces the apoptosis of Raji cells arrested at G1 phase. a Fluorescence image of Raji cells treated with DAPI after 48 h incubation with wogonin at the concentration of 0 -200 μmol/L. Nuclear fragmentation and chromatin condensation are indicated with red arrows. b The apoptosis of Raji cells was determined by flow cytometry after incubation with wogonin at 0 -200 μmol/L for 48 h. The ratio of apoptosis was 6.44 ± 1.26%, 8.86 ± 0.74%, 12.94 ± 2.68% and 17.58 ± 3.73% for each group. c The cell cycle of Raji cells was arrested by wogonin (50 μmol/L) at G1 phase. d The ratio of S, G1, G2 phase was 22.77 ± 1.6%, 44.30 ± 1.91%, 32.93 ± 1.78% for the control group and 10.98 ± 1.17%, 70.04 ± 1.23%, 18.99 ± 0.65% for the wogonin treated group respectively, it was significantly up regulated at sub-G1 peak in wogonin treated group. The different levels of significance were indicated as *P < 0.05 and **P < 0.01

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