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Table 3 Relationship between expressions of 34 selected genes and Kaplan-Meier analysis

From: In search of druggable targets for GBM amino acid metabolism

 

Enzymes for which …

higher expression is linked to poor survival

lower expression is linked to poor survival

expression is not correlated with survival

Enzymes with higher expression in GBM

BCAT1 a

ASLa

LAP3

PIPOX a

GFPT2

DDO a

FAH

DDAH2

SHMT2

TYMS

SHMT1

TDO2

IDO1

Enzymes with expression as in normal brain

CNDP2

GSS a

GLUL (GS)

PHGDH

SEPHS1

ABAT

ALT (GPT)

AGXT

ASNS

MTR

Enzymes with lower expression in GBM

PRODH a

ASS1 a

AST (GOT1)

ASPA a

PAH

GLUD1/GLUD2

GAD1/GAD2

GLS

TH

  1. aSurvival curves for footnoted genes are shown in Fig. 3. Genes in bold have concordant protein (by IHC) and mRNA expression (by microarray)