Table 2 Percentage of cases with hypermethylation
From: BRCA2 carriers with male breast cancer show elevated tumour methylation
|  | GSTP1 | RASSF1A | MAL | TWIST | RUNX3 | RARβ | APC | FOXC1 | CDH1 | WIF1 | TOTAL HYPERMETHYLATED GENES | AMI (mean) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
BRCA1 (n = 3) | 2 (66%) | 1 (33%) | 1 (33%) | 0 | 1 (33%) | 1 (33%) | 1 (33%) | 1 (33%) | 0 | 1 (33%) | 9 (30%) | 13.4 |
BRCA2 (n = 25) | 22 (88%) | 20 (80%) | 14 (56%) | 13 (52%) | 8 (32%) | 11 (44%) | 8 (32%) | 6 (24%) | 0 | 11 (44%) | 113 (45%) | 23.6 |
BRCAX (n = 32) | 25 (78%) | 20 (63%) | 12 (38%) | 9 (28%) | 9 (28%) | 6 (19%) | 7 (22%) | 8 (25%) | 0 | 14 (56%) | 110 (34%) | 17.0 |
All (n = 60) | 49 (82%) | 41 (68%) | 27 (45%) | 22 (37%) | 18 (30%) | 18 (30%) | 16 (27%) | 15 (25%) | 0 | 26 (43%) | 232 (39%) | 14.0 |
|  |  |  |  | p = 0.06 |  | p = 0.08 |  |  |  |  | P < 0.01 | p = 0.01 |