Table 3 Correlation of hypermethylation with clinicopathological variables (associations approaching significance, p < 0.05 in bold)

Hypermethylation

+

-

+

-

+

-

+

-

+

-

+

-

+

-

>

<

Age (years)

59.1

65.7

67.2

60.9

69.1

60.4

p-value

0.04

0.07

0.01

Tumour size (mm)

22.3

16.5

21.4

17.1

20.8

15.8

p-value

0.01

0.08

0.02

IC-NST Histology

94%

69%

p-value

0.046

Grade 3

51%

18%

p-value

0.09

Paget’s Disease

31%

8%

p-value

0.04

DCIS present

33%

6%

p-value

0.02

Lymphovascular invasion

49%

18%

20%

51%

53%

40%

p-value

0.09

0.07

0.09

Perineural invasion

63%

36%

p-value

0.07

Node positive

52%

24%

62%

34%

p-value

0.08

0.07

HER2 positive

13%

0

p-value

0.11