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Table 5 Hazard ratios (HR) and 95% confidence intervals (CI) for breast cancer characteristics in relation to risk of cancer-specific mortality and overall mortality

From: Descriptive characteristics of prostate cancer in patients with a history of primary male breast cancer – a SEER analysis

 

Breast cancer-specific mortality

Overall mortality

 

Crude modela

Multivariable-adjusted modelb

Crude modela

Multivariable-adjusted modelb

 

HR

(95% CI)

HR

(95% CI)

HR

(95% CI)

HR

(95% CI)

Age at index breast cancer, years

 <55

0.77

(0.64–0.92)

0.70

(0.53–0.91)

0.25

(0.22–0.28)

0.20

(0.17–0.24)

 55–64

0.75

(0.63–0.90)

0.63

(0.48–0.82)

0.31

(0.28–0.35)

0.25

(0.22–0.30)

 65–74

0.68

(0.57–0.81)

0.71

(0.55–0.92)

0.44

(0.39–0.48)

0.44

(0.39–0.51)

 75+

 

Reference

 

Reference

 

Reference

 

Reference

 P trend

 

<0.001

 

0.014

 

<0.001

 

<0.001

Race/ethnicity

 Non-Hispanic White

 

Reference

 

Reference

 

Reference

 

Reference

 Black

1.82

(1.54–2.15)

1.70

(1.31–2.20)

1.34

(0.19–1.52)

1.56

(1.31–1.87)

 Asian/Pacific Islander/Alaska Native

0.99

(0.71–1.37)

0.97

(0.60–1.59)

0.77

(0.62–0.97)

0.73

(0.53–0.99)

 Hispanic

1.10

(0.83–1.48)

1.27

(0.85–1.91)

0.93

(0.76–1.13)

1.12

(0.86–1.47)

Breast cancer AJCC stage

 I

 

Reference

 

Reference

 

Reference

 

Reference

 II

2.53

(2.01–3.17)

1.44

(1.01–2.03)

1.47

(1.31–1.65)

1.31

(1.09–1.56)

 III

6.75

(5.36–8.49)

3.18

(2.12–4.77)

2.48

(2.18–2.82)

2.34

(1.86–2.96)

Hormone receptor status

 ER/PR negative

 

Reference

 

Reference

 

Reference

 

Reference

 ER and/or PR positive

0.51

(0.39–0.67)

0.71

(0.48–1.05)

0.78

(0.63–0.96)

0.86

(0.65–1.13)

Tumor size

        

 <2 cm

 

Reference

 

Reference

 

Reference

 

Reference

 ≥2 cm

2.90

(2.40–3.50)

1.67

(1.27–2.19)

1.85

(1.66–2.06)

1.22

(1.04–1.44)

Lymph node status

 Negative

 

Reference

 

Reference

 

Reference

 

Reference

 Positive

3.49

(3.04–4.02)

1.91

(1.46–2.51)

1.54

(1.42–1.68)

1.12

(0.96–1.31)

Radiation

 No

 

Reference

 

Reference

 

Reference

 

Reference

 Yes

1.59

(1.38–1.81)

0.83

(0.68–1.02)

1.10

(1.00–1.21)

0.77

(0.68–0.89)

  1. aCrude model estimates adjusted for SEER registry and year of diagnosis only
  2. bMultivariable-adjusted model estimates adjusted for age, race/ethnicity, breast cancer AJCC stage, hormone receptor status, tumor size, lymph node status, radiation, surgery, SEER registry and year of diagnosis
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BMC Cancer

ISSN: 1471-2407

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