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Fig. 1 | BMC Cancer

Fig. 1

From: Serial pseudoprogression of metastatic malignant melanoma in a patient treated with nivolumab: a case report

Fig. 1

The gross and histological findings of the resected esophageal melanoma. a Gross examination. There was an irregular elevated black lesion in the lower esophagus. b Macroscopic findings (Hematoxylin-eosin staining). The tumor showed proliferation of eosinophilic tumor cells. c Hematoxylin-eosin staining of tumor cells. There were solid proliferation and tumor cells had large round nuclear. Melanin pigments were sometimes found. d Melan A immunostaining and Giemsa as counterstain. Tumor cells were diffusely positive and there were some of melanin pigments. e CD8 immunostaining and Giemsa as counterstain. Few numbers of cells were positive (arrowhead) and melanin pigments were seen. f PD-L1/CD274 (SP142) immunostaining and Giemsa as counterstain. There were no positive cells in the tumor. Melanin pigments were found

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