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Table 2 Associations between NUDT15 c.415C > T and risk of leukopenia, hepatotoxicity and therapy interruption

From: Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?

 

NUDT15 (rs116855232, c.415C > T)

Dominant model

CC(n = 74)

CT(n = 29)

TT(n = 2)

P value OR (95% CI)

Leukopenia (WBC < 2 × 109/L)

 No

63

19

0

0.009

 Yes

11

10

2

3.617 (1.377–9.051)

Early-onset leukopenia (WBC < 2 × 109/L)

 No

70

20

0

3.75 × 10−4

 Yes

4

9

2

9.63(2.764–33.514)

Hepatotoxicity (AST/ALT> 500 IU/L)

 No

70

27

2

0.883

 Yes

4

2

0

1.207 (0.209–6.957)

Therapy interruption

 No

58

27

2

0.077

 Yes

16

2

0

0.25 (0.054–1.162)

  1. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated using logistic regression
  2. Early-onset leukopenia was defined as leukopenia occurrence during the first 60 days of the maintenance therapy
  3. Dominant model (CT + TT vs CC)
  4. Abbreviations: WBC white blood cells, ALT alanine aminotransferase, AST aspartate aminotransferase
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BMC Cancer

ISSN: 1471-2407

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