Variable | levels | Mitotic count per 2Â mm2 | CCND1 copy number ratiob | ||||
---|---|---|---|---|---|---|---|
<  8 / 2 mm2 | ≥ 8 / 2 mm2 |  | <  0 | >  0 |  | ||
N (%) | N (%) | p valuea | N (%) | N (%) | p valuea | ||
Age | <  65 | 133 (47) | 133 (49) | 0.72 | 101 (49) | 129 (48) | 0.72 |
 | ≥ 65 | 150 (53) | 141 (51) |  | 104 (51) | 142 (52) |  |
Nodal status | negative | 173 (61) | 135 (49) | 0.005 | 112 (55) | 152 (56) | 0.75 |
 | positive | 110 (39) | 139 (51) |  | 93 (45) | 119 (44) |  |
T stage | T1–2 | 262 (93) | 235 (86) | 0.01 | 180 (88) | 245 (90) | 0.36 |
 | T3–4 | 21 (7) | 39 (14) |  | 25 (12) | 26 (10) |  |
Grade | grade 1–2 | 279 (99) | 90 (33) | < 0.001 | 142 (69) | 171 (63) | 0.16 |
 | grade 3 | 4 (1) | 184 (67) |  | 63 (31) | 100 (37) |  |
PgR | negative | 116 (42) | 143 (52) | 0.02 | 92 (46) | 132 (50) | 0.42 |
 | positive | 157 (58) | 130 (48) |  | 108 (54) | 133 (50) |  |
Her2 | negative | 257 (93) | 226 (84) | < 0.001 | 180 (90) | 233 (87) | 0.46 |
 | positive | 3 (1) | 38 (14) |  | 13 (7) | 22 (8) |  |
 | missing | 16 (6) | 6 (2) |  | 7 (4) | 12 (4) |  |
Ki67 | <  5% | 104(53) | 94 (42) | 0.02 | 72 (54) | 92 (46) | 0.78 |
 | ≥ 5% | 92 (47) | 130 (58) |  | 88 (55) | 106 (54) |  |
Cyclin D1 | below median | 106 (53) | 100 (42) | 0.02 | 76 (49) | 105 (48) | 0.85 |
 | above median | 93 (47) | 140 (58) |  | 80 (51) | 115 (52) |  |
mitotic count | <  8 per 2 mm2 | 283 (100) | 0(0) | na | 116 (57) | 126 (47) | 0.03 |
 | ≥ 8 per 2 mm2 | 0(0) | 274 (100) |  | 87 (43) | 142 (53) |  |
CCND1 log 2 copy number ratiob | <  0 | 116 (48) | 87 (38) | 0.03 | 205 (100) | 0(0) | na |
>  0 | 126 (52) | 142 (62) |  | 0(0) | 271 (100) |  |