Fig. 2From: MAFb protein confers intrinsic resistance to proteasome inhibitors in multiple myelomaHigh MAFb expression is associated with resistance to PIs. SACHI (a), H929 (b), EJM (c), XG2 (d), L363 (e), and OPM-2 (f) cells were seeded at 2 × 10^4 per well in 96-well plates in the presence of indicated concentrations of Bzb or CFZ for 48 h. Cell survival was measured by MTT Assay. Results are presented as mean ± SE (n = 4). Data are representative of 3 separate experiments. HMCLs were treated with serial concentrations of Bzb (G) and CFZ (H) for 48 h and cell viability was measured by MTT assay. The IC50 of Bzb (G) and CFZ (H) were classified based on MAFb protein (+) or (−)Back to article page