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Table 3 Significant results of the follow-up analysis in the acute lymphoid leukemia population

From: Possible roles of genetic variations in chemotherapy related cardiotoxicity in pediatric acute lymphoblastic leukemia and osteosarcoma

Gene

SNP

Genotype group 1 / group 2

Mean FS % ± SE

genotype group 1 (N)

Mean FS % ± SE

genotype group 2 (N)

P value

Follow-up category

ABCB1

rs9282564

AA /

AG + GG

41.5 ± 0.7 (100)

37.9 ± 1.1 (29)

2 .50E-03

10–15 years after Dx

ABCC1

rs35626

GG /

GT + TT

41.0 ± 0.6 (92)

39.0 ± 0.6 (127)

7 .90E-03

2–5 years after Dx

ABCC2

rs3740066

GG / GA / AA

39.5 ± 0.5 (112)

40.8 ± 0.5 (112) / 42.9 ± 0.9 (33)

4 .50E-03

5–10 years after Dx

NQO1

rs1043470

CC /

CT + TT

40.9 ± 0.5 (198)

38.1 ± 0.9 (53)

2 .60E-03

acute phase

SLC22A6

rs6591722

TT + TA /

AA

40.7 ± 0.4 (227)

37.8 ± 1.0 (28)

5 .90E-03

5–10 years after Dx

SLC28A3

rs7853758

GG /

GA + AA

41.3 ± 0.7 (96)

38.4 ± 1.1 (36)

4 .80E-03

10–15 years after Dx

SLC28A3

rs885004

GG /

GA + AA

41.3 ± 0.7 (95)

38.0 ± 1.1 (33)

2 .50E-03

10–15 years after Dx

  1. Results are from multivariate general linear model performed on the ALL cohort adjusted for potential confounders. Abbreviations: Dx, diagnosis; FS, fractional shortening; N, number; SE, standard error