Fig. 3

Intratumor heterogeneity. In the context of the stresses from the external environment and the need for nutritional sources, onco-evolution takes place in the solid tumor and various subclones form. Subclone B, for example, is a group of hypoxia-resistant tumor cells and subclone C is another group of invasive tumor cells known as ITF. These subclones undoubtedly possess their own molecular characteristics which poses a formidable hurdle in the process from biomarkers discovery to application