Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer

Chen, Minbin; Jiang, Baohu; He, Bangshun; Tang, Min; Wang, Ping; Chen, Li; Lu, Jianwei; Lu, Peihua

doi:10.1186/s12885-018-4818-3

BMC Cancer

Table 4 PRKAA1 Polymorphisms with Gastric Cancer Risk by Tumor Classification

From: Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer

Genotype	Co	Site						DIF						TNM
		GCA			NGCA			Low			Med-high			T1-T2		T3-T4
		Ca	OR (95% CI)^a	P	Ca	OR (95% CI)^a	P	Ca	OR (95% CI)^a	P	Ca	OR (95% CI)^a	P	Ca	OR (95% CI)^a	P	Ca	OR (95% CI)^a	P
rs10074991
AA	128	43	Reference		61	Reference		47	Reference		57	Reference		35	Reference		69	Reference
AG	261	73	0.80(0.51,1.24)	0.312	182	1.45(1.01,2.09)	0.043	104	1.09(0.73,1.63)	0.683	151	1.28(0.88,1.86)	0.203	88	1.23(0.79,1.94)	0.362	167	1.16(0.82,1.66)	0.409
GG	101	24	0.66(0.37,1.16)	0.150	98	2.02(1.32,3.07)	0.001	44	1.17(0.71,1.93)	0.528	77	1.66(1.08,2.57)	0.022	36	1.33(0.77,2.29))	0.308	86	1.51(0.99,2.28)	0.054
AG/GG	362	97	0.77(0.50,1.16)	0.210	280	1.16(1.14,2.28)	0.007	148	1.20(0.76,1.65)	0.570	229	1.38(0.97,1.98)	0.074	124	1.27(0.82,1.95)	0.283	253	1.26(0.90,1.77)	0.171
Additive model			0.82(2.62,1.08)	0.163		1.43(1.16,1.76)	0.001		1.09(0.86,1.40)	0.475		1.31(1.05,1.62)	0.016		1.17(0.89,1.53)	0.255		1.24(1.01,1.53)	0.039
rs13361707
TT	129	43	Reference		60	Reference		47	Reference		56	Reference		35	Reference		68	Reference
TC	260	73	0.80(0.52,1.25)	0.330	183	1.51(1.05,2.17)	0.027	104	1.10(0.73,1.65)	0.641	152	1.32(0.91,1.93)	0.141	88	1.25(0.80,1.97)	0.331	168	1.20(0.84,1.71)	0.320
CC	101	24	0.66(0.37,1.17)	0.157	98	2.08(1.36,3.16)	0.001	44	1.19(0.72,1.95)	0.495	78	1.71(1.11,2.65)	0.015	36	1.34(0.78,2.31)	0.290	86	1.55(1.02,2.34)	0.040
TC/CC	361	97	0.77(0.51,1.17)	0.225	281	1.67(1.18,2.36)	0.004	148	1.13(0.77,1.67)	0.529	230	1.42(1.00,2.05)	0.050	124	1.28(0.83,1.98)	0.257	254	1.30(0.93,1.82)	0.125
Additive model			0.82(0.62,1.09)	0.171		1.45(1.18,1.78)	0.001		1.10(0.86,1.40)	0.451		1.32(1.07,1.64)	0.012		1.18(0.90,1.54)	0.240		1.26(1.02,1.55)	0.030
rs154268
TT	297	88	Reference		183	Reference		115	Reference		156	Reference		90	Reference		181	Reference
TC	176	48	0.89(0.59,1.33)	0.567	131	1.24(0.92,1.66)	0.153	70	1.05(0.74,1.49)	0.794	109	1.18(0.86,1.61)	0.299	63	1.12(0.85,1.82)	0.258	116	1.46(0.85,1.82)	0.704
CC	17	4	0.77(0.25.2.39)	0.657	27	2.54(1.34,4.81)	0.004	10	1.46(0.65,3.31)	0.364	21	2.38(1.20,4.58)	0.010	6	1.14(0.43,3.02)	0.790	25	2.46(1.28,4.70)	0.007
TC/CC	193	52	0.88(0.60,1.31)	0.535	158	1.36(1.03,1.81)	0.032	80	1.09(0.78,1.53)	0.614	130	1.28(0.95,1.73)	0.099	69	1.24(0.86,1.79)	0.253	141	1.19(0.89,1.58)	0.240
Additive model			0.89(0.63,1.26)	0.508		1.40(1.10,1.76)	0.005		1.12(0.84,1.49)	0.449		1.33(1.04,1.70)	0.025		1.19(0.87,1.63)	0.289		1.27(1.00,1.61)	0.046
rs461404
AA	298	88	Reference		182	Reference		114	Reference		156	Reference		90	Reference		180	Reference
GA	175	48	0.90(0.60,1.34)	0.596	131	1.25(0.93,1.68)	0.132	71	1.08(0.76,1.54)	0.668	108	1.18(0.86,1.61)	0.383	63	1.25(0.86,1.83)	0.243	116	1.08(0.80,1.46)	0.628
GG	17	4	0.78(0.25,2.40)	0.659	28	2.67(1.42,5.04)	0.002	10	1.48(0.65,3.34)	0.349	22	2.47(1.27,4.79)	0.007	6	1.23(0.58,2.61)	0.787	26	2.59(1.36,4.93)	0.004
GA/GG	192	52	0.89(0.60,1.32)	0.563	159	1.38(1.05,1.84)	0.023	81	1.12(0.80,1.58)	0.509	130	1.29(0.96,1.74)	0.116	69	1.25(0.86,1.80)	0.240	142	1.21(0.91,1.62)	0.187
Additive model			0.90(0.63,1.27)	0.532		1.42(1.13,1.79)	0.003		1.14(0.85,1.52)	0.373		1.34(1.05,1.72)	0.019		1.19(0.87,1.64)	0.276		1.30(1.03,1.65)	0.029

^aAdjusted for age, gender, smoking, drinking, and Helicobacter pylori infection; GCA gastric cardia adenocarcinoma, NGCA non-gastric cardia adenocarcinoma, Ca, case Co control

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