From: Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer
Genotype | All patients | NGCA | ||||||
---|---|---|---|---|---|---|---|---|
HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI)a | p-Value | HR (95% CI)b | p-Value | |
rs10074991 | ||||||||
AA | Reference | Reference | Reference | Reference | ||||
AG | 1.16(0.87,1.55) | 0.300 | 1.62(1.10,2.38) | 0.015 | 1.63(1.10,2.41) | 0.015 | 1.80(1.21,2.67) | 0.004 |
GG | 1.15(0.83,1.59) | 0.401 | 1.64(1.08,2.49) | 0.020 | 1.71(1.12,2.60) | 0.012 | 1.75(1.13,2.70) | 0.012 |
AG/GG | 1.16(0.88,1.52) | 0.290 | 1.62(1.12,2.35) | 0.011 | 1.66(1.14,2.41) | 0.008 | 1.78(1.21,2.61) | 0.003 |
rs13361707 | ||||||||
TT | Reference | Reference | Reference | Reference | ||||
TC | 1.18(0.89,1.57) | 0.253 | 1.67(1.13,2.47) | 0.010 | 1.68(1.13,2.50) | 0.010 | 1.85(1.24,2.77) | 0.003 |
CC | 1.16(0.84,1.61) | 0.364 | 1.68(1.10,2.56) | 0.016 | 1.76(1.15,2.68) | 0.009 | 1.79(1.16,2.78) | 0.009 |
TC/CC | 1.18(0.90,1.54) | 0.246 | 1.67(1.15,2.44) | 0.007 | 1.71(1.17,2.50) | 0.006 | 1.83(1.24,2.70) | 0.002 |
rs154268 | ||||||||
TT | Reference | Reference | ||||||
TC | 1.08(0.85,1.36) | 0.525 | 1.18(0.90,1.56) | 0.242 | ||||
CC | 1.23(0.78,1.94) | 0.367 | 1.29(0.78,2.12) | 0.322 | ||||
TC/CC | 1.10(0.88,1.17) | 0.405 | 1.20(0.92,1.56) | 0.183 | ||||
rs6882903 | ||||||||
CC | Reference | Reference | ||||||
CA | 0.97(0.76,1.24) | 0.796 | 1.12(0.84,1.48) | 0.443 | ||||
AA | 1.48(0.89,2.47) | 0.130 | 1.56(0.90,2.72) | 0.113 | ||||
CA/AA | 1.02(0.81,1.29) | 0.869 | 1.17(0.89,1.53) | 0.252 | ||||
rs3805490 | ||||||||
TT | Reference | Reference | ||||||
TA | 1.03(0.82,1.30) | 0.807 | 1.07(0.81,1.41) | 0.626 | ||||
AA | 0.82(0.51,1.31) | 0.404 | 0.97(0.55,1.68) | 0.898 | ||||
TA/AA | 0.99(0.80,1.24) | 0.953 | 1.06(0.81,1.37) | 0.691 | ||||
rs461404 | ||||||||
AA | Reference | Reference | ||||||
GA | 1.08(0.86,1.37) | 0.506 | 1.19(0.90,1.56) | 0.352 | ||||
GG | 1.25(0.80,1.94) | 0.333 | 1.31(0.80,2.13) | 0.228 | ||||
GA/GG | 1.11(0.89,1.38) | 0.379 | 1.21(0.93,1.57) | 0.165 |