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Fig. 4 | BMC Cancer

Fig. 4

From: Molecular iodine inhibits the expression of stemness markers on cancer stem-like cells of established cell lines derived from cervical cancer

Fig. 4

I2 treatment significantly reduces OCT-4, SOX2, KLF4 and NANOG in HeLa cells grown as spheres. Monolayer cultures of HeLa cells were treated with 200 μM (I2) for 24 h (tinted grey with line), without treatment (black line), isotype (long dashes) (a, d, g, j). Sphere cultures of HeLa cells were treated with 200 μM (I2) for 24 h (tinted grey with line), without treatment (black line), isotype (long dashes) (b, e, h, k). Markers were analyzed by flow cytometry. (a, b, d, e, g, h, j, k). Data are expressed as mean ± SD (n = 3 independent assays), and the asterisk indicates a significant difference with respect to the control (**P < 0.01, ***P < 0.001) (c, f, i, l)

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