Fig. 4

The antitumor efficacy against SW480 tumor xenografts. (a) Tumor size was measured every 3 d, and tumor volume was calculated. Tumor size decreased significantly in the KGHV500 combined with CIK treatment group. (b) There were more apoptotic tumor cells found in the KGHV500 combined with CIK cells group than in any other group (green: TUNEL, blue: DAPI × 1000). (c) The expression of caspase-3, caspase-7, p53, Bcl-2 and survivin genes in adenovirus or CIK cell-treated group detected by Q-PCR. p53, caspase-3 and caspase-7 gene expression was increased by KGHV500 combined with CIK cells treatment, and Bcl-2 and survivin gene expression was decreased by KGHV500 combined with CIK cells treatment