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Table 3 Objective response rate by crizotinib treatment

From: Crizotinib in advanced non-small-cell lung cancer with concomitant ALK rearrangement and c-Met overexpression

Response

No. of Patients (%)

P-value

ALK + c-Met-

(n = 101)

ALK + c-Met+

(n = 15)

Complete response, n (%)

0(0.0%)

0(0.0%)

 

Partial response, n (%)

60(59.4%)

13(86.7%)

 

Stable disease, n (%)

25(24.8%)

2(13.3%)

 

Progressive disease, n (%)

16(15.8%)

0(0.0%)

 

ORR, %

59.4%

86.7%

0.041

DCR, %

84.2%

100%

0.126

  1. Abbreviations: ALK anaplastic lymphoma kinase, c-Met cellular-mesenchymal-epithelial transition, ALK + c-Met+ patients with ALK rearrangement and c-Met overexpression positive, ALK + c-Met- patients with ALK rearrangement and c-Met overexpression negative