| Mean (SD) | Mean Change from Baseline (SD) | Model Estimate (95% CI, p)b | ||
---|---|---|---|---|---|
Outcomesa | Intervention | Control | Intervention | Control | Interaction effect |
Physical Function | |||||
 Baseline | 87.4 (15.6) | 90.2 (12.7) |  |  | 2.75 (0.65, 4.86), p = 0.011 |
 Time 2 | 85.2 (17.5) | 83.9 (16.7) | −2.2 (15.2) | −6.3 (14.1) | |
 Time 3/4 | 84.5 (16.1) | 81.8 (17.0) | −2.9 (15.0) | −8.5 (16.8) | |
Depression | |||||
 Baseline | 4.2 (4.4) | 3.5 (3.4) |  |  | −0.72 (−1.23, − 0.22) p = 0.005 |
 Time 2 | 4.9 (4.0) | 5.4 (3.3) | 0.7 (3.5) | 1.9 (3.2) | |
 Time 3/4 | 3.9 (3.6) | 4.64 (4.3) | −0.3 (3.4) | 1.2 (4.2) | |
Fatigue | |||||
 Baseline | 27.7 (20.5) | 23.8 (18.9) |  |  | − 3.12 (−6.29, 0.04) p = 0.053 |
 Time 2 | 37.6 (23.5) | 41.0 (22.8) | 9.8 (21.0) | 17.3 (22.7) | |
 Time 3/4 | 34.4 (21.8) | 36.7 (21.0) | 6.7 (21.4) | 12.9 (23.8) | |
CIPN Sensory | |||||
 Baseline | 3.9 (9.6) | 3.3 (6.6) |  |  | −1.67 (−3.90, 0.55) p = 0.141 |
 Time 2 | 7.8 (11.9) | 6.4 (10.3) | 4.0 (9.7) | 3.1 (9.1) | |
 Time 3/4 | 12.9 (14.3) | 15.7 (18.2) | 9.0 (14.2) | 12.4 (19.0) | |
CIPN Motor | |||||
 Baseline | 4.5 (10.1) | 2.5 (4.0) |  |  | −1.3 (−2.95, 0.35) p = 0.122 |
 Time 2 | 5.7 (11.5) | 5.3 (7.4) | 1.2 (6.2) | 2.8 (6.6) | |
 Time 3/4 | 8.9 (12.7) | 9.6 (13.4) | 4.5 (11.7) | 7.1 (13.1) | |
Current Pain Intensity | |||||
 Baseline | 1.7 (1.9) | 1.5 (1.9) |  |  | −0.09 (−0.37, 0.18) p = 0.500 |
 Time 2 | 1.72 (1.9) | 1.6 (1.9) | 0.03 (2.3) | 0.10 (2.2) | |
 Time 3/4 | 1.7 (1.9) | 1.7 (1.8) | 0.00 (1.8) | 0.19 (2.2) | |
Insomnia | |||||
 Baseline | 28.4 (24.9) | 27.7 (26.8) |  |  | −0.62 (−4.58, 3.35) p = 0.760 |
 Time 2 | 31.2 (29.6) | 33.6 (25.9) | 2.8 (31.6) | 6 (28.7) | |
 Time 3/4 | 28.3 (24.9) | 28.9 (27.0) | −0.05 (24.6) | 1.19 (32.2) | |
High Cumulative Dose Category (n = 84) | |||||
 CIPN Sensory |  |  |  |  |  |
  Baseline | 4.0 (12.3) | 3.5 (6.2) |  |  | −5.70 (−9.89, −1.60) p = 0.007 |
  Time 2 | 8.1(12.7) | 7.7 (13.0) | 4.1 (10.8) | 4.2 (12.7) | |
  Time 3/4 | 13.8 (14.3) | 24.7 (22.4) | 9.8 (14.0) | 21.2 (23.9) | |
CIPN Motor | |||||
  Baseline | 4.2 (10.7) | 2.0 (3.4) |  |  | −3.45 (−6.70, −0.19) p = 0.039 |
  Time 2 | 4.9 (10.3) | 5.1 (7.3) | 0.7 (6.0) | 3.2 (6.9) | |
  Time 3/4 | 8.6 (10.7) | 13.3 (17.8) | 4.4 (12.9) | 11.3 (17.6) |