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Table 2 Results from the multivariablea analysis using the mixture cure model on the significant SNPs identified by the univariable mixture cure model

From: A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer

Genomic location

Genetic model

rs number (genotypes a vs. b)

Genotype freq.

Metastasis probability

Time-to-metastasis

OR

95% CI

p-value

HR

95% CI

p-value

22:17793969

Recessive

rs5749032 (GG vs. AA + AG)

14%

0.38

0.14–1.07

0.066

15.86

6.83–36.83

1.28 × 10−10

17:77361176

Co-Dominant

rs12949587 (CT vs. CC)

20%

0.66

0.32–1.37

0.261

7.56

3.44–16.61

4.63 × 10−7

20:15111138

Co-Dominant

rs6110524 (AG vs. GG)

17%

0.95

0.44–2.04

0.887

4.80

2.00–11.53

4.52 × 10−4

7:33913404

Recessive

rs3815652 (TT vs. CC + CT)

4%

0.59

0.13–2.65

0.488

12.97

3.26–51.66

2.78 × 10−4

14:100691178

Recessive

rs756055 (CC vs. TT + TC)

13%

0.28

0.10–0.82

0.020

7.58

2.53–22.65

2.90 × 10−4

14:100730920

Recessive

rs7153665 (AA vs. GG + AG)

13%

0.28

0.10–0.82

0.020

7.58

2.53–22.65

2.90 × 10−4

11:100430053

Recessive

rs4754687 (AA vs. CC + CA)

11%

0.51

0.18–1.43

0.201

8.13

2.59–25.53

3.28 × 10−4

5:155345221

Dominant

rs2163746 (CT + CC vs. TT)

24%

0.49

0.23–1.07

0.075

9.65

3.67–25.37

4.29 × 10−6

5:155361116

Dominant

rs17053011 (TG + TT vs. GG)

24%

0.49

0.23–1.07

0.075

9.65

3.67–25.37

4.29 × 10−6

  1. aAdjusted for the significant baseline characteristics: tumor location, 5-fluorouracil treatment status, and tumor stage. Each SNP was analyzed separately adjusting for these factors. Patients with missing data were excluded, resulting in the inclusion of 349 stage I-III patients with MSI-L/MSS tumors
  2. Linkage disequilibrium (LD) calculations indicated that rs756055 and rs7153665 as well as rs2163746 and rs17053011 are in complete pairwise LD (r2 = 1)
  3. The SNPs listed yielded similar hazard ratio estimates under the univariable (Additional file 1: Table S3) and multivariable analyses. Consequently, all of the SNPs identified in this study could be considered independent prognostic factors for time-to-metastasis in colorectal cancer if the results are replicated using independent cohort data
  4. Genotype freq. frequency of genotype a calculated from the patient cohort, OR odds ratio for metastasis comparing odds of metastasis in subgroup a with that in subgroup b, HR hazard ratio comparing metastasis rate in subgroup a with that in subgroup b among those who are susceptible to metastasis, CI confidence interval