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Table 4 Variant information for the significant genotypes in the multivariable mixture cure and Cox proportional hazards regression models

From: A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer

Genomic location

rs number (genotypea)

MAFb

Statistical modelc

Type of variant (gene)d

DNA binding evidencee

22:17793969

rs5749032 (GG)

40%

Mixture cure

Intergenic

ND

20:16189263

rs2327990 (TT)

11%

Cox proportional hazards

Intergenic

Less likely to affect binding

3:134513356

rs11918092 (CC)

8%

Cox proportional hazards

Intronic (EPHB1)

Minimal binding evidence

3:134515336

rs3732568 (AA)

8%

Cox proportional hazards

Intronic (EPHB1)

Minimal binding evidence

3:59930672

rs2366964 (CC)

8%

Cox proportional hazards

Intronic (FHIT)

ND

2:6769988

rs1563948 (AA)

11%

Cox proportional hazards

Intronic (MIR7515)

Minimal binding evidence

2:6773920

rs11694697 (TT)

11%

Cox proportional hazards

Intronic (MIR7515)

ND

2:6777992

rs11692570 (TT)

11%

Cox proportional hazards

Intronic (MIR7515)

Minimal binding evidence

2:6779277

rs2219613 (TT)

11%

Cox proportional hazards

Intronic (MIR7515)

Minimal binding evidence

6:91187510

rs1145724 (GG)

9%

Cox proportional hazards

Intergenic

Minimal binding evidence

  1. a Risk increasing/decreasing genotype, b MAF calculated from patient cohort analyzed. Values comparable to CEU population based on 1000 Genomes Project Phase 3 28 data obtained through the Ensembl database (http://grch37.ensembl.org/), c Statistical model identifying the association, d based on Ensembl database [25], e based on RegulomeDB database [26]. ND: no data