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Fig. 2 | BMC Cancer

Fig. 2

From: Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model

Fig. 2

Mesenchymal and cancer stem-cell like features in TU-BcX-2 K1 cells. a Panel of epithelial (CD24, CDH1) and mesenchymal (CDH2, VIM, FRA1, SNAI1, TWIST, cFOS, cMYC and SLUG) genes analyzed by qRT-PCR in TU-BcX-2 K1 tumors passaged in mice (T2, T3, T4, T6). There were no endogenous levels of CD44 in any TU-BcX-2 K1 tumors passaged in mice and very low levels of CDH2 in T3 and T6 and CD24 in T3. Due to limited tissue availability, one sample was obtained per passage and analyzed. Data was normalized to β-actin. b Immunohistochemistry staining for CDH1 protein expression in the TU-BcX-2 K1 T3 tumor. Representative images in inserts are shown at 200X magnification. c Flow cytometry of circulating tumor cells and matched TU-BCx-2 K1 tumor explants. Mouse cells are HLA- and human cells are HLA+; N = 2

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