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Fig. 4 | BMC Cancer

Fig. 4

From: miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms’ tumor

Fig. 4

MicroRNA-140-5p suppresses IGF-1R and TGFBR I signaling pathways. Expression of the main proteins in IGF-1R and TGFBR I signaling pathways were detected in tumor tissues, siRNA transfected cells and microRNA-140-5p overexpressed cells. TGFBRI/SMAD2/3 and IGF1R/P-AKT expression were detected in the nephroblastoma tissues and adjacent normal tissues, shown were representative results from 3 experiments (a). SMAD2/3 expression was downregulated by inhibition of TGFBRI (b), whereas AKT activation was downregulated by inhibition of IGF1R (c) in G401 and WT-CLS1 cells. MicroRNA-140-5p could suppress TGFBRI/SMAD2/3 and IGF1R/P-AKT expression in G401 (d) and WT-CLS1 cells (e)

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BMC Cancer

ISSN: 1471-2407

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