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Fig. 5 | BMC Cancer

Fig. 5

From: miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms’ tumor

Fig. 5

Overexpression of TGFBRI and IGF1R could abolish the inhibitory effects of microRNA-140-5p. Exogenous TGFBRI and IGF1R were introduced into microRNA-140-5p overexpressed G401 cells. Overexpression of IGF1R could rescue activation of AKT and overexpression of TGFBRI could rescue SMAD2/3 expression (a, b and c). Overexpression of TGFBRI and IGF1R could rescue cell proliferation rate inhibited by miR-140-5p in G401 cells. *P < 0.05 (d)

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