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Table 3 Clinical chemistry results in male BALB/c mice injected with IRDye800CW-nimotuzumab

From: Pre-clinical study of IRDye800CW-nimotuzumab formulation, stability, pharmacokinetics, and safety

Parameter

baseline

day 2

day 14

(male)

vehicle

Nz-800CW

vehicle

Nz-800CW

mean ± sd

mean ± sd

mean ± sd

unit

A:G Ratio

1.5 ± 0.1

1.6 ± 0.1

1.6 ± 0.2

1.6 ± 0.0

1.7 ± 0.1

 

ALT

24.8 ± 5.0

27.6 ± 4.0

25.2 ± 4.1

27.2 ± 3.3

22.8 ± 2.6

U/L

Albumin

28.5 ± 0.6

29.4 ± 1.1

29.4 ± 1.5

30.8 ± 1.8

31.5 ± 0.6

g/L

Alk Phos

114 ± 9

131 ± 4

122 ± 11

123 ± 3

114 ± 7

U/L

Amylase

2893 ± 836

3167 ± 247

2883 ± 127

3130 ± 223

3692 ± 764

U/L

CK

310 ± 127

255 ± 187

217 ± 78

380 ± 131

356 ± 154

U/L

Calcium

2.4 ± 0.3

2.5 ± 0.1

2.5 ± 0.1

2.6 ± 0.1

2.5 ± 0.1

mmol/L

Chloride

105 ± 1

105 ± 2

105 ± 0.8

102 ± 1.5

104 ± 1.7

mmol/L

Cholesterol

3.3 ± 0.2

3.3 ± 0.2

3.4 ± 0.1

3.2 ± 0.2

3.2 ± 0.2

mmol/L

Creatinine

15.8 ± 3.0

15.5 ± 2.6

17.2 ± 2.4

17.8 ± 2.3

13.4 ± 2.3

μmol/L

GLDH

7.2 ± 1.3

9.8 ± 1.9

8.6 ± 1.1

7.0 ± 0.7

6.0 ± 0.8

U/L

Globulin

18.8 ± 1.0

19.0 ± 1.2

19.0 ± 1.4

19.2 ± 1.1

18.8 ± 1.0

g/L

Glucose

15.4 ± 2.7

12.8 ± 1.7

13.8 ± 1.6

12.8 ± 2.8

13.8 ± 1.1

mmol/L

Lipase

27.0 ± 0.8

27.4 ± 2.5

25.0 ± 4.2

28.4 ± 2.3

28.8 ± 1.8

U/L

Magnesium

1.1 ± 0.1

1.1 ± 0.1

1.1 ± 0.1

1.2 ± 0.1

1.1 ± 0.1

mmol/L

Na:K Ratio

35.5 ± 1.3

37.8 ± 2.8

41.5 ± 3.7

40.6 ± 7.1

38.5 ± 1.9

 

Phosphorus

2.9 ± 0.3

2.3 ± 0.5

2.5 ± 0.3

3.0 ± 0.2

2.6 ± 0.3

mmol/L

Potassium

4.2 ± 0.2

4.1 ± 0.3

3.6 ± 0.3

3.7 ± 0.7

4.0 ± 0.2

mmol/L

Sodium

151 ± 2

154 ± 3

150 ± 2

149 ± 2

151 ± 2

mmol/L

Total Bilirubin

0.1 ± 0.2

0.3 ± 0.4

0.7 ± 0.4

0.2 ± 0.2

0.4 ± 0.5

μmol/L

Total Protein

47.2 ± 1.0

48.4 ± 0.6

48.4 ± 0.6

50.0 ± 2.8

49.8 ± 1.6

g/L

Urea

8.7 ± 0.2

10.4 ± 0.6

9.6 ± 1.1

9.8 ± 1.5

9.0 ± 1.5

mmol/L

  1. Abbreviations: Nz-800 IRDye800CW-nimotuzumab, A:G albumin to globulin, ALT alanine aminotransferase, alk phos alkaline phosphatase, CK creatin kinase, GLDH glutamate dehydrogenase, Na:K sodium to potassium