Association of ZNF331 and WIF1 methylation in peripheral blood leukocytes with the risk and prognosis of gastric cancer

Table 3 Combined effects of ZNF331 and WIF1 (ZW) methylation and GC risk

Methylation status		Case (%)	Control (%)	Crude OR(95% CI)	P	OR^a (95% CI)	P	OR^b (95% CI)	P	P-trend^c
ZW	1	151 (44.5)	79 (23.2)	1.000		1.000		1.000
	2	154 (45.4)	193 (56.6)	0.417 (0.296–0.589)	< 0.001*	0.471 (0.285–0.776)	0.003*	0.419 (0.286–0.614)	< 0.001*
	3	34 (10.0)	69 (20.2)	0.258 (0.158–0.422)	< 0.001*	0.407 (0.202–0.821)	0.012*	0.274 (0.158–0.474)	< 0.001*	< 0.001*

1: Both ZNF331 and WIF1 were low methylated
2: One low and the other high
3: Both ZNF331 and WIF1 were high methylated
CI confidence interval, OR odds ratio, GC gastric cancer
* Statistically significant
^a Adjusted for age, sex, BMI, monthly income, occupation, family history of GC, H. pylori infection, green vegetables, garlic, beef and mutton, freshwater fish, fried food, refrigerated food, egg, food left overnight, alcohol consumption, water, salted food, dairy products and irregular diet
^b Adjusted for propensity score of all variables
^c The Cochran-Armitage trend test

ISSN: 1471-2407