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Table 4 Association between smoking variables and histologic subtypes of lung cancer

From: Risk of lung cancer among women in relation to lifetime history of tobacco smoking: a population-based case-control study in France (the WELCA study)

 

CONTROLS

ADENOCARCINOMA (1)

SQUAMOUS CELL CARCINOMA (2)

SMALL CELL CARCINOMA (3)

p-value for Homogeneity Test

N = 757

N = 514

OR (95%CI)

N = 67

OR (95%CI)

N = 88

OR (95%CI)

(1)/(2)

(1)/(3)

(2)/(3)

SMOKING STATUS

 Never smokers

341

129

Ref

7

Ref

3

Ref

   

 Former smokers

246

149

1.76 (1.31; 2.37)

24

5.23 (2.17; 12.59)

15

7.66 (2.17; 27.10)

0.15

0.89

0.43

 Current smokers

170

236

3.50 (2.61; 4.70)

36

12.56 (5.33; 29.58)

70

59.43 (18.11; 194.97)

0.01

<  0.001

0.01

INTENSITY

 Per 10 cigarettes/day

 

2.04 (1.79; 2.31)

 

2.82 (2.23; 3.56)

 

3.45 (2.79; 4.28)

0.01

<  0.001

0.14

DURATION

 Per 10 years

  

1.44 (1.35; 1.54)

 

2.04 (1.71; 2.43)

 

2.83 (2.26; 3.55)

<  0.001

<  0.001

0.02

PACK-YEARS

 Per 10 pack-years

 

1.55 (1.45; 1.66)

 

1.86 (1.66; 2.09)

 

2.13 (1.90; 2.38)

<  0.001

<  0.001

0.04

TIME SINCE CESSATION (among ever smokers)

 Per 1 year

  

0.96 (0.94; 0.97)

 

0.92 (0.89; 0.95)

 

0.87 (0.82; 0.91)

0.03

<  0.001

0.05

CSI

 Per 1 CSI unit

 

2.54 (2.18; 2.96)

 

5.12 (3.61; 7.26)

 

9.98 (6.60; 15.09)

<  0.001

<  0.001

0.01

  1. Abbreviations: CI confidence interval, CSI comprehensive smoking index, OR odds ratio
  2. Odds ratio were adjusted for age (continuous), area of residence, education, and BMI 2 years before the interview (continuous)