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Fig. 2 | BMC Cancer

Fig. 2

From: Validation of genomic and transcriptomic models of homologous recombination deficiency in a real-world pan-cancer cohort

Fig. 2

The HRD-DNA model predicts HRD status from gwLOH. A Thresholds for calling a sample HRD+ for breast and ovarian cancer were set based on the maximum F1-score within samples in the training set. B Metrics used to assess HRD-DNA performance within the evaluation set. The confidence interval for breast cancer was [1, 1] and ovarian cancer AUC was [0.979, 1]. C Distribution of gwLOH scores across different HRR genotypes in the evaluation set. HRR mutated samples contain samples with either monoallelic or biallelic loss in a select number of HRR genes. Values in the box represent the median gwLOH percentage within each HRR genotype (**** p-value < 0.0001 for Wilcoxon test). Dotted lines are the thresholds chosen in (A) for each cancer type. Statistical differences between HRR-WT and BRCA biallelic loss were not shown, but all were significant (p-value < 0.0001 for Wilcoxon test)

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