Skip to content

Advertisement

Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

Page 1 of 47
  1. Content type: Research article

    The anti-tumor properties of cannabinoids have been investigated in many in vitro and in vivo studies. Many of these anti-tumor effects are mediated via cannabinoid receptor types 1 and 2 (CB1 and CB2), comprisin...

    Authors: Mohammed I. Khan, Anna A. Sobocińska, Klaudia K. Brodaczewska, Katarzyna Zielniok, Malgorzata Gajewska, Claudine Kieda, Anna M. Czarnecka and Cezary Szczylik

    Citation: BMC Cancer 2018 18:583

    Published on:

  2. Content type: Research article

    Carbonic anhydrase related proteins (CARPs) VIII, X and XI functionally differ from the other carbonic anhydrase (CA) enzymes. Structurally, they lack the zinc binding residues, which are important for enzyme ...

    Authors: Sini L. Karjalainen, Hannu K. Haapasalo, Ashok Aspatwar, Harlan Barker, Seppo Parkkila and Joonas A. Haapasalo

    Citation: BMC Cancer 2018 18:584

    Published on:

  3. Content type: Research article

    Tumor-associated macrophages (TAMs) play a critical role in modulating the tumor microenvironment and promote tumor metastases. Our studies have demonstrated that ginsenoside Rh2 (G-Rh2), a monomeric compound ...

    Authors: Honglin Li, Nan Huang, Weikang Zhu, Jianchun Wu, Xiaohui Yang, Wenjing Teng, Jianhui Tian, Zhihong Fang, Yingbin Luo, Min Chen and Yan Li

    Citation: BMC Cancer 2018 18:579

    Published on:

  4. Content type: Research article

    Lung cancer remains the top contributor to cancer-related mortality worldwide. Long non-coding RNAs (lncRNAs) have been reported to participate in normal development and tumorigenesis. LncRNA nuclear enriched ...

    Authors: Wu Zhou, Xing Chen, Qinghua Hu, Xuliang Chen, Yingji Chen and Lingjin Huang

    Citation: BMC Cancer 2018 18:580

    Published on:

  5. Content type: Research article

    A-disintegrin and metalloproteinases (ADAMs) are members of a family of multidomain transmembrane and secreted proteins. Specific ADAMs are upregulated in human cancers and correlated with tumor progression an...

    Authors: Xiaodong Jiao, Wenlong Yu, Jianxin Qian, Ying Chen, Peilian Wei, Wenzheng Fang and Guanzhen Yu

    Citation: BMC Cancer 2018 18:570

    Published on:

  6. Content type: Research article

    Glutamate oxaloacetate transaminase 1 (GOT1) regulates cellular metabolism through coordinating the utilization of carbohydrates and amino acids to meet nutrient requirements. KRAS mutated cancer cells were re...

    Authors: Xiaoshan Zhou, Sophie Curbo, Fuqiang Li, Shuba Krishnan and Anna Karlsson

    Citation: BMC Cancer 2018 18:559

    Published on:

  7. Content type: Research article

    Osteosarcoma is the most common primary bone cancer in children and young adults. It is highly aggressive and patients that present with metastasis have a poor prognosis. Angiopoietin-like 4 (ANGPTL4) drives t...

    Authors: T. Zhang, A. Kastrenopoulou, Q. Larrouture, N. A. Athanasou and H. J. Knowles

    Citation: BMC Cancer 2018 18:536

    Published on:

  8. Content type: Research article

    SETDB1 is a histone H3K9 methyltransferase, which plays a significant role in the occurrence and progression of tumors. Previous studies have confirmed that T-lymphom invasion and metastasis gene (Tiam1) is a ...

    Authors: Yuqin Zhang, Jing Huang, Qisheng Li, Keli Chen, Yonghao Liang, Zetao Zhan, Feng Ye, Wen Ni, Longhua Chen and Yi Ding

    Citation: BMC Cancer 2018 18:539

    Published on:

  9. Content type: Research article

    Neuropilin-1 (NRP-1), a non-tyrosine kinase glycoprotein receptor, is associated with poor prognosis breast cancer, however transcriptomic changes triggered by NRP-1 overexpression and its association with che...

    Authors: Adviti Naik, Aida Al-Yahyaee, Nada Abdullah, Juda-El Sam, Noura Al-Zeheimi, Mahmoud W. Yaish and Sirin A. Adham

    Citation: BMC Cancer 2018 18:533

    Published on:

  10. Content type: Research article

    NKX2.5 is a transcription factor transiently expressed during thyroid organogenesis. Recently, several works have pointed out the oncogenic role of NKX2.5 in a variety of tumors. We therefore hypothesized that...

    Authors: Ricardo Cortez Cardoso Penha, Luisa Aguirre Buexm, Fabiana Resende Rodrigues, Taciana Padilha de Castro, Maria Carolina S. Santos, Rodrigo Soares Fortunato, Denise P. Carvalho, Luciene C. Cardoso-Weide and Andrea C. F. Ferreira

    Citation: BMC Cancer 2018 18:498

    Published on:

  11. Content type: Research article

    PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in cell proliferation and tumorigenesis. However, the precise mechanism of action of PCNP in the process of tumor growth has not yet...

    Authors: Dong-Dong Wu, Ying-Ran Gao, Tao Li, Da-Yong Wang, Dan Lu, Shi-Yu Liu, Ya Hong, Hui-Bin Ning, Jun-Ping Liu, Jia Shang, Jun-Feng Shi, Jian-She Wei and Xin-Ying Ji

    Citation: BMC Cancer 2018 18:499

    Published on:

  12. Content type: Research article

    Gastric cancer is the eighth most common cancer in Taiwan, with a 40% 5-year survival rate. Approximately 40% of patients are refractory to chemotherapy. Currently, the anti-HER2 therapy is the only clinically...

    Authors: Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Chih-Wei Yen, Huang-Wei Xu, Yi-Fang Deng, Ying-Jhen Lin, Wan-Ting Hsu, Cheng-Shyong Wu and Chin Li

    Citation: BMC Cancer 2018 18:508

    Published on:

  13. Content type: Research article

    The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highes...

    Authors: Beate Hegge, Eva Sjøttem and Ingvild Mikkola

    Citation: BMC Cancer 2018 18:496

    Published on:

  14. Content type: Research article

    Tamoxifen is a frontline therapy for estrogen receptor (ER)-positive breast cancer in premenopausal women. However, many patients develop resistance to tamoxifen, and the mechanism underlying tamoxifen resista...

    Authors: Wei Li, Ling Xu, Xiaofang Che, Haizhou Li, Ye Zhang, Na Song, Ti Wen, Kezuo Hou, Yi Yang, Lu Zhou, Xing Xin, Lu Xu, Xue Zeng, Sha Shi, Yunpeng Liu, Xiujuan Qu…

    Citation: BMC Cancer 2018 18:507

    Published on:

  15. Content type: Technical advance

    The E-selectin ligands expressed by cancer cells mediate adhesion of circulating cancer cells to endothelial cells, as well as within tissue microenvironments important for tumor progression and metastasis. Th...

    Authors: Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein and Paula A. Videira

    Citation: BMC Cancer 2018 18:495

    Published on:

  16. Content type: Research article

    Hepatocellular carcinoma (HCC) often arises in the setting of chronic inflammation with multiple inhibitory immune signals. V-domain Ig suppressor of T cell activation (VISTA) is identified as a novel negative...

    Authors: Ming Zhang, Hua-Jin Pang, Wei Zhao, Yu-Fa Li, Li-Xu Yan, Zhong-Yi Dong and Xiao-Feng He

    Citation: BMC Cancer 2018 18:511

    Published on:

  17. Content type: Research article

    The calcium-binding protein calretinin (gene name: CALB2) is currently considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma (MM). MM is a very aggressive tumor strongly...

    Authors: Walter Blum, László Pecze, Janine Wörthmüller Rodriguez, Martine Steinauer and Beat Schwaller

    Citation: BMC Cancer 2018 18:475

    Published on:

  18. Content type: Research article

    Human Papillomavirus (HPV) infection is the main risk factor for the development and progression of cervical cancer. HPV-16 E6 and E7 expression is essential for induction and maintenance of the transformed ph...

    Authors: Tatiana Rabachini, Enrique Boccardo, Rubiana Andrade, Katia Regina Perez, Suely Nonogaki, Iolanda Midea Cuccovia and Luisa Lina Villa

    Citation: BMC Cancer 2018 18:485

    Published on:

Page 1 of 47