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Surgical oncology, cancer imaging, and interventional therapeutics

Section edited by Stephen P. Povoski

This section focuses on clinical research that impacts on the diagnosis and treatment of cancer using surgery, diagnostic imaging, interventional therapeutics, and surgical pathology.

Page 1 of 17

  1. The 21-gene recurrence score (RS) can predict chemotherapy benefit in estrogen receptor-positive, human epidermal growth factor receptor-2-negative (ER+/HER2-) early breast cancer patients. Age would influence...

    Authors: Jing Yu, Caijin Lin, Jiahui Huang, Jin Hong, Weiqi Gao, Siji Zhu, Lin Lin, Xiaosong Chen, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Jiayi Wu and Kunwei Shen

    Citation: BMC Cancer 2021 21:707

    Content type: Research article

    Published on:

  2. The number of colorectal cancer patients increases with age. The decision to go through major surgery can be challenging for the aged patient and the surgeon because of the heterogeneity within the older popul...

    Authors: Susanna Niemeläinen, Heini Huhtala, Anu Ehrlich, Jyrki Kössi, Esa Jämsen and Marja Hyöty

    Citation: BMC Cancer 2021 21:698

    Content type: Study protocol

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  3. Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that lack of effective therapeutic drugs. K-001 is an oral antitumor drug made from active ingredients of marine microorganisms. The current study ai...

    Authors: Jiujie Cui, Haiyan Yang, Jue Liu, Donghui Chen, Jiong Hu, Haiyan Zhang, Yu Wang, Ting Han, Tiebo Mao, Feng Jiao, Ewelina Biskup, Yaotian Pan, Min Liu and Liwei Wang

    Citation: BMC Cancer 2021 21:672

    Content type: Research article

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  4. The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy).

    Authors: Christer Borgfeldt, Erik Holmberg, Janusz Marcickiewicz, Karin Stålberg, Bengt Tholander, Elisabeth Åvall Lundqvist, Angelique Flöter-Rådestad, Maria Bjurberg, Pernilla Dahm-Kähler, Kristina Hellman, Elisabet Hjerpe, Preben Kjölhede, Per Rosenberg and Thomas Högberg

    Citation: BMC Cancer 2021 21:658

    Content type: Research article

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  5. Clinical practice guidelines recommend active surveillance as the preferred treatment option for low-risk prostate cancer, but only a minority of eligible men receive active surveillance, and practice variatio...

    Authors: Shellie D. Ellis, Soohyun Hwang, Emily Morrow, Kim S. Kimminau, Kelly Goonan, Laurie Petty, Edward Ellerbeck and J. Brantley Thrasher

    Citation: BMC Cancer 2021 21:649

    Content type: Research article

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  6. In estrogen receptor (ER)-positive breast cancer (BC), young age is associated with poor prognosis. While very young patients respond better to chemotherapy, chemotherapy is less effective in ER-positive tumor...

    Authors: Joohyun Woo, Se Jeong Oh, Jeong-Yoon Song, Byung Joo Chae, Jung Eun Choi, Jeeyeon Lee, Heung Kyu Park and Woosung Lim

    Citation: BMC Cancer 2021 21:647

    Content type: Research article

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  7. Radical pancreaticoduodenectomy is the most common treatment strategy for patients diagnosed with adenocarcinoma of the pancreatic head. Few studies have reported the clinical characteristics and treatment eff...

    Authors: Chao Wu, Sheng Zhong Hou, Zuowei Wu, Xing Huang, Zihe Wang and Bole Tian

    Citation: BMC Cancer 2021 21:624

    Content type: Research article

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  8. Increasing evidence indicates that site-distant metastases are associated with survival outcomes in patients with epithelial ovarian cancer. This study aimed to investigate the prognostic values of site-distan...

    Authors: Bo Wang, Shixuan Wang and Wu Ren

    Citation: BMC Cancer 2021 21:609

    Content type: Research article

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  9. The influence of lymph node dissection (LND) on survival in patients with head and neck neurogenic tumors remains unclear. We aimed to determine the effect of LND on the outcomes of patients with head and neck...

    Authors: Xiaolian Fang, Shengcai Wang, Junyang Zhao, Yamei Zhang, Jie Zhang, Yanzhen Li, Xiaodan Li, Jun Tai and Xin Ni

    Citation: BMC Cancer 2021 21:598

    Content type: Research article

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  10. The routine clinical use of serum prostatic specific antigen (PSA) testing has allowed earlier detection of low-grade prostate cancer (PCa) with more favourable characteristics, leading to increased acceptance...

    Authors: Salonee Shah, Kerri Beckmann, Mieke Van Hemelrijck, Ben Challacombe, Rick Popert, Prokar Dasgupta, Jonah Rusere, Grace Zisengwe, Oussama Elhage and Aida Santaolalla

    Citation: BMC Cancer 2021 21:573

    Content type: Database

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  11. Percutaneous magnetic resonance-guided (MR-guided) MWA procedures have traditionally been performed under local anesthesia (LA) and sedation. However, pain control is often difficult to manage, especially in s...

    Authors: Zhaonan Li, Chaoyan Wang, Jing Li, Zaoqu Liu, Dechao Jiao and Xinwei Han

    Citation: BMC Cancer 2021 21:562

    Content type: Research article

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  12. The aim of this study was to evaluate the relationship between pre-treatment plasma fibrinogen (Fib) level and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients a...

    Authors: Yihua Wang, Yu Wang, Rui Chen, Zhenrong Tang, Yang Peng, Yudi Jin, Ailin Lan, Nan Ding, Yuran Dai, Linshan Jiang and Shengchun Liu

    Citation: BMC Cancer 2021 21:542

    Content type: Research article

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  13. Neoadjuvant chemotherapy (NACT) was initially applied to locally advanced breast cancer to convert advanced lesions to an operable status. Currently, its application has been expanded to enhance overall oncolo...

    Authors: Jia-Ruei Yang, Wen-Ling Kuo, Chi-Chang Yu, Shin-Cheh Chen and Jung-Ju Huang

    Citation: BMC Cancer 2021 21:522

    Content type: Research article

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  14. Definitive radiation therapy (dRT) is an effective initial treatment of intermediate-risk (IR) and high-risk (HR) prostate cancer (PCa). PSMA PET/CT is superior to standard of care imaging (CT, MRI, bone scan)...

    Authors: Jeremie Calais, Shaojun Zhu, Nader Hirmas, Matthias Eiber, Boris Hadaschik, Martin Stuschke, Ken Herrmann, Johannes Czernin, Amar U. Kishan, Nicholas G. Nickols, David Elashoff and Wolfgang P. Fendler

    Citation: BMC Cancer 2021 21:512

    Content type: Study protocol

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  15. To investigate the feasibility, safety and efficacy of percutaneous radiofrequency ablation (RFA) of pulmonary metastases from hepatocellular carcinoma (HCC) contiguous with the mediastinum using the artificia...

    Authors: Taiyang Zuo, Wenli Lin, Fengyong Liu and Jinshun Xu

    Citation: BMC Cancer 2021 21:505

    Content type: Research article

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  16. Stereotactic Ablative Body Radiotherapy (SABR) is a non-invasive treatment which allows delivery of an ablative radiation dose with high accuracy and precision. SABR is an established treatment for both primar...

    Authors: Yoo Young Dominique Lee, Doan Trang Nguyen, Trevor Moodie, Ricky O’Brien, Anne McMaster, Andrew Hickey, Nicole Pritchard, Per Poulsen, Elizaveta Mitkina Tabaksblat, Britta Weber, Esben Worm, David Pryor, Julie Chu, Nicholas Hardcastle, Jeremy Booth, Val Gebski…

    Citation: BMC Cancer 2021 21:494

    Content type: Study protocol

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  17. We aimed to evaluate the prognosis in patients with synchronous endometrial and ovarian cancer (SEOC) by comparing the differences between double primary cancer (DPC) and metastatic cancer (MC).

    Authors: Wonkyo Shin, Sang-Yoon Park, Sokbom Kang, Myong Cheol Lim and Sang-Soo Seo

    Citation: BMC Cancer 2021 21:489

    Content type: Research article

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  18. Primary effusion lymphoma is a rare, aggressive large B-cell lymphoma strictly linked to infection by Human Herpes virus 8/Kaposi sarcoma-associated herpes virus. In its classic form, it is characterized by bo...

    Authors: Magda Zanelli, Francesca Sanguedolce, Maurizio Zizzo, Andrea Palicelli, Maria Chiara Bassi, Giacomo Santandrea, Giovanni Martino, Alessandra Soriano, Cecilia Caprera, Matteo Corsi, Stefano Ricci, Linda Ricci and Stefano Ascani

    Citation: BMC Cancer 2021 21:468

    Content type: Research article

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  19. The high incidence and mortality rate of colorectal cancer require new technologies to improve its early diagnosis. This study aims at extracting the medical needs related to the endoscopic technology and the ...

    Authors: Juan Francisco Ortega-Morán, Águeda Azpeitia, Luisa F. Sánchez-Peralta, Luis Bote-Curiel, Blas Pagador, Virginia Cabezón, Cristina L. Saratxaga and Francisco M. Sánchez-Margallo

    Citation: BMC Cancer 2021 21:467

    Content type: Research article

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  20. It is reported that appropriately 50% of early breast cancer patients with 1–2 positive sentinel lymph node (SLN) micro-metastases could not benefit from axillary lymph node dissection (ALND) or breast-conserv...

    Authors: Yang Yu, Zhijun Wang, Zhongyin Wei, Bofan Yu, Peng Shen, Yuan Yan and Wei You

    Citation: BMC Cancer 2021 21:466

    Content type: Research article

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  21. Selecting patients with peritoneal metastases from colorectal cancer (CRCPM) who might benefit from cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is challenging. Compu...

    Authors: M. P. Engbersen, C. J. V. Rijsemus, J. Nederend, A. G. J. Aalbers, I. H. J. T. de Hingh, V. Retel, D. M. J. Lambregts, E. J. R. J. Van der Hoeven, D. Boerma, M. J. Wiezer, M. De Vries, E. V. E. Madsen, A. R. M. Brandt-Kerkhof, S. Van Koeverden, P. R. De Reuver, R. G. H. Beets-Tan…

    Citation: BMC Cancer 2021 21:464

    Content type: Study protocol

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  22. Soft-tissue sarcomas (STS) are rare tumors of the soft tissue. Recent diagnostic studies on STS mainly dealt with only few cases of STS and did not investigate the post-therapeutic performance of MRI in a rout...

    Authors: Sam Sedaghat, Maya Sedaghat, Jens Meschede, Olav Jansen and Marcus Both

    Citation: BMC Cancer 2021 21:398

    Content type: Research article

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  23. Astrocytoma is a common type of central nervous system tumor. In this study, we investigated the correlation between ST6GAL1 and CYP19A1 polymorphisms and the risk and prognosis of astrocytoma.

    Authors: Tuo Wang, Yao Sun, Zichao Xiong, Jiamin Wu, Xiaoying Ding, Xiaoye Guo and Yuan Shao

    Citation: BMC Cancer 2021 21:391

    Content type: Research article

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  24. Pancreatic ductal adenocarcinoma (PDAC) is a leading causes of cancer mortality worldwide. Currently, laparoscopic pancreatic resection (LPR) is extensively applied to treat benign and low-grade diseases relat...

    Authors: Ke Chen, Yu Pan, Chao-jie Huang, Qi-long Chen, Ren-chao Zhang, Miao-zun Zhang, Guan-yu Wang, Xian-fa Wang, Yi-ping Mou and Jia-fei Yan

    Citation: BMC Cancer 2021 21:382

    Content type: Research article

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  25. Despite improvements in median survival some patients with advanced ovarian cancer die within 100 days of diagnosis; the reasons for which remain poorly understood.

    Authors: Amy Hawarden, Bryn Russell, Mary Ellen Gee, Fatima Kayali, Andrew Clamp, Emma Jayne Crosbie and Richard John Edmondson

    Citation: BMC Cancer 2021 21:378

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:614

  26. Given their widespread availability and relatively low cost, percutaneous thermal ablation is commonly performed under the guidance of computed tomography (CT) or ultrasound (US). However, such imaging modalit...

    Authors: Zhaonan Li, Chaoyan Wang, Guangyan Si, Xueliang Zhou, Yahua Li, Jing Li, Dechao Jiao and Xinwei Han

    Citation: BMC Cancer 2021 21:366

    Content type: Research article

    Published on:

  27. Angiogenesis assessment is important for personalized therapeutic intervention in patients with non-small-cell lung cancer (NSCLC). This study investigated whether radiologic parameters obtained by dynamic con...

    Authors: Yu-Sen Huang, Jenny Ling-Yu Chen, Hsin-Ming Chen, Li-Hao Yeh, Jin-Yuan Shih, Ruoh-Fang Yen and Yeun-Chung Chang

    Citation: BMC Cancer 2021 21:348

    Content type: Research article

    Published on:

  28. The present study aimed to assess the lower invasiveness of robot-assisted transmediastinal radical esophagectomy by prospectively comparing this procedure with transthoracic esophagectomy in terms of perioper...

    Authors: Shuntaro Yoshimura, Kazuhiko Mori, Motonari Ri, Susumu Aikou, Koichi Yagi, Yukinori Yamagata, Masato Nishida, Hiroharu Yamashita, Sachiyo Nomura and Yasuyuki Seto

    Citation: BMC Cancer 2021 21:338

    Content type: Research article

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  29. Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms with malignant behaviors that can develop from inert slow growth or low malignancy to aggressive metastasis during follow-up. Rec...

    Authors: Bo Zhou, Jie Xiang, Ming Jin, Xiang Zheng, Guogang Li and Sheng Yan

    Citation: BMC Cancer 2021 21:334

    Content type: Research article

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  30. Ovarian clear cell carcinoma (OCCC) is a special pathological type of epithelial ovarian carcinoma (EOC). We conducted this research to investigate the clinical characteristics and outcomes of OCCC and to prov...

    Authors: Chenchen Zhu, Jing Zhu, Lili Qian, Hanyuan Liu, Zhen Shen, Dabao Wu, Weidong Zhao, Weihua Xiao and Ying Zhou

    Citation: BMC Cancer 2021 21:322

    Content type: Research article

    Published on:

  31. Breast cancer and its treatment imposes a significant effect in the quality of life (QOL) of women. Being a developing country with contrasting social and cultural norms to the West, Sri Lankan women may have ...

    Authors: Ravindri Jayasinghe, Ashan Fernando, Umesh Jayarajah and Sanjeewa Seneviratne

    Citation: BMC Cancer 2021 21:305

    Content type: Research article

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  32. Neoadjuvant therapy has several potential advantages over upfront surgery in patients with localized pancreatic cancer; more patients receive systemic treatment, fewer patients undergo futile surgery, and R0 r...

    Authors: Q. P. Janssen, J. L. van Dam, B. A. Bonsing, H. Bos, K. P. Bosscha, P. P. L. O. Coene, C. H. J. van Eijck, I. H. J. T. de Hingh, T. M. Karsten, M. B. van der Kolk, G. A. Patijn, M. S. L. Liem, H. C. van Santvoort, O. J. L. Loosveld, J. de Vos-Geelen, B. M. Zonderhuis…

    Citation: BMC Cancer 2021 21:300

    Content type: Study protocol

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  33. Breast cancer-related lymphedema (BCRL) is associated with extensive axillary dissection. Axillary lymph node dissection (ALND) based on breast lymphatics level (BLL) was proposed to minimize the surgical exte...

    Authors: Qianqian Yuan, Jinxuan Hou, Yukun He, Yiqian Liao, Lewei Zheng and Gaosong Wu

    Citation: BMC Cancer 2021 21:293

    Content type: Research article

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  34. If the depth of gallbladder malignant tumor (GBMT) invasion is deeper than the subserosa (ss), cholecystectomy is insufficient. In past reports that used endoscopic ultrasonography (EUS) to diagnose the depth ...

    Authors: Mitsuru Sugimoto, Hiroki Irie, Mika Takasumi, Minami Hashimoto, Yuka Oka, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Tsunetaka Kato, Ryoichiro Kobashi, Yuko Hashimoto, Shigeru Marubashi, Takuto Hikichi…

    Citation: BMC Cancer 2021 21:288

    Content type: Technical advance

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  35. The accurate prediction of post-hepatectomy early recurrence (PHER) of hepatocellular carcinoma (HCC) is vital in determining postoperative adjuvant treatment and monitoring. This study aimed to develop and va...

    Authors: Rong-yun Mai, Jie Zeng, Wei-da Meng, Hua-ze Lu, Rong Liang, Yan Lin, Guo-bin Wu, Le-qun Li, Liang Ma, Jia-zhou Ye and Tao Bai

    Citation: BMC Cancer 2021 21:283

    Content type: Research article

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  36. Although criteria for liver transplantation, such as the Milan criteria and Hangzhou experiences, have become popular, criteria to guide adjuvant therapy for patients with hepatocellular carcinoma after liver ...

    Authors: Dabing Huang, Yinan Shen, Wei Zhang, Chengxiang Guo, Tingbo Liang and Xueli Bai

    Citation: BMC Cancer 2021 21:280

    Content type: Research article

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  37. Bile duct invasion is a relatively rare event and is not well characterised in hepatocellular carcinoma (HCC). It remains very difficult to diagnose HCC with bile duct tumour thrombus (BDTT) before surgery. In...

    Authors: Jun-Yi Wu, Ju-Xian Sun, Jia-Yi Wu, Xiao-Xiao Huang, Yan-Nan Bai, Yong-Yi Zeng, Zhi-Bo Zhang, Shu-Qun Cheng and Mao-Lin Yan

    Citation: BMC Cancer 2021 21:272

    Content type: Research article

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  38. Probe electrospray ionization-mass spectrometry (PESI-MS) can rapidly visualize mass spectra of small, surgically obtained tissue samples, and is a promising novel diagnostic tool when combined with machine le...

    Authors: Sho Kiritani, Kentaro Yoshimura, Junichi Arita, Takashi Kokudo, Hiroyuki Hakoda, Meguri Tanimoto, Takeaki Ishizawa, Nobuhisa Akamatsu, Junichi Kaneko, Sen Takeda and Kiyoshi Hasegawa

    Citation: BMC Cancer 2021 21:262

    Content type: Research article

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  39. The aim of this study was to investigate the relationship between multiple metabolism parameters derived from FDG and tumor TNM stages as well as tumor metastasis-associated protein of GLUT-1 and MACC1 in colo...

    Authors: Mingyu Zhang, Jigang Yang, Hao Jiang, Huijie Jiang and Zhenchang Wang

    Citation: BMC Cancer 2021 21:258

    Content type: Research article

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  40. The current standard postoperative treatment for stage II-IIIA non-small cell lung cancer (NSCLC) is a regimen of platinum doublet adjuvant chemotherapy. These regimens, which are the same as for solid NSCLC t...

    Authors: Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Shoji Tokunaga, Hiroyuki Yamaguchi, Koichi Tomoshige, Hironosuke Watanabe, Takeshi Nagayasu and Kenji Sugio

    Citation: BMC Cancer 2021 21:249

    Content type: Study protocol

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  41. Cancer-associated fibroblasts (CAFs) are some of the most abundant components of the tumour microenvironment. A recent study suggested that in some cancers, CAFs express programmed death ligand 1 (PD-L1), whic...

    Authors: Katsuhiro Yoshikawa, Mitsuaki Ishida, Hirotsugu Yanai, Koji Tsuta, Mitsugu Sekimoto and Tomoharu Sugie

    Citation: BMC Cancer 2021 21:239

    Content type: Research article

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  42. Recent studies have shown that mixed predominantly differentiated-type (MD) early gastric cancer (EGC) might have more malignant potential than pure differentiated-type (PD) EGC. However, no study has analyzed...

    Authors: Yutaka Okagawa, Tetsuya Sumiyoshi, Hitoshi Kondo, Yusuke Tomita, Takeshi Uozumi, Reiichi Iida, Hiroya Sakano, Kaho Tokuchi, Takashi Jin, Masahiro Yoshida, Akira Sakurada, Ryoji Fujii, Takeyoshi Minagawa, Kohtaro Morita, Kei Yane, Hideyuki Ihara…

    Citation: BMC Cancer 2021 21:235

    Content type: Research article

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  43. The role of surgery for the primary tumor in breast cancer patients with bone metastases (BM) remains unclear. The purpose of this study was to determine the impact of surgery for the primary tumor in breast c...

    Authors: Zhangheng Huang, Xin Zhou, Yuexin Tong, Lujian Zhu, Ruhan Zhao and Xiaohui Huang

    Citation: BMC Cancer 2021 21:222

    Content type: Research article

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  44. Predicting the possibility of ipsilateral lateral cervical lymph node metastasis (ipsi-LLNM) was crucial to the operation plan for patients with papillary thyroid carcinoma (PTC). This study aimed to investiga...

    Authors: Ying Zou, Huanlei Zhang, Wenfei Li, Yu Guo, Fang Sun, Yan Shi, Yan Gong, Xiudi Lu, Wei Wang and Shuang Xia

    Citation: BMC Cancer 2021 21:221

    Content type: Research article

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  45. We assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy.

    Authors: Takeshi Tsutsumi, Kazumasa Komura, Takeshi Hashimoto, Ryu Muraoka, Naoya Satake, Tomohisa Matsunaga, Takuya Tsujino, Yuki Yoshikawa, Tomoaki Takai, Koichiro Minami, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki…

    Citation: BMC Cancer 2021 21:201

    Content type: Research article

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