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Table 2 Studied populations of CSCs and T-cells

From: Effects of reprogrammed splenic CD8+ T-cells in vitro and in mice with spontaneous metastatic Lewis lung carcinoma

CSCs populations

T-cells populations/Characteristic

Axl+

CD8+CD45RA+CD197hiCD62L+CD95+ / Stem cell–like memory (TSCM) CD8+ T cells. This population have high self-renewability, multipotency and proliferation capacity

Axl+Sox2+

CD3+CD4+CD8−Ki67+ / Proliferating CD4+T-cells

Axl+CD117+

CD3+CD4+Ki67+PD-1+ / Activated proliferating CD4+T-cells

CD44hiCD90+Sox2+

CD3+CD8+Ki67+PD-1+ / Activated proliferating CD8+T-cells

CD117+CD44+

CD3+CD8+Ki67+ / Proliferating CD8+T-cells

CD117+EGF+CD44+PD-L1+PD-1+

CD3+CD8+PD-1+ / Exhausted CD8+ T-cells. This population is characterized by decreased antigen-dependent cytokine secretion and increased expression of inhibitory surface receptors

CD117+Sox2+

CD4−CD3−CD8+CD62L+ / Memory CD8+T-cells

CD117+EGF+

 

CD117+EGF+CD44+

 

EGF+CD44+Sox2+

 

CD117+EGF+CD44+Sox2+

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