Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer

Han, Ji-Yuan; Che, Na; Mo, Jing; Zhang, Dan-Fang; Liang, Xiao-Hui; Dong, Xue-Yi; Zhao, Xiu-Lan; Sun, Bao-Cun

doi:10.1186/s12885-024-12229-2

Fig. 6

From: Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer

The expressions of function-associated proteins and pathway-associated proteins were determined in shDsg2 and shDsc2 BC cells by western blot. (A) Cells were lysed and lysates subjected to western blot to detect N-cadherin, E-cadherin, CD133, cyclin D1 and β-catenin with the respective antibodies. (B) Cells were stimulated with 10 ng/ml EGF for 24 h after starved in serum-free DMEM for 24 h. Subsequently, the cells were lysed and western blot was performed using antibodies against EGFR pathways. Data are presented as mean ± SD from three separate experiments. *indicates P < 0.05; ns, not significant

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Fig. 6

BMC Cancer

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