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  1. Enhancer of zesta homologue 2 (EZH2) is an essential component of polycomb repressive complex 2 (PRC2) that contributes to tumor progression and chemo-resistance. The aim of this study was to comprehensively a...

    Authors: Brett M. Reid, Shraddha Vyas, Zhihua Chen, Ann Chen, Peter A. Kanetsky, Jennifer B. Permuth, Thomas A. Sellers and Ozlen Saglam

    Citation: BMC Cancer 2021 21:714

    Content type: Research

    Published on:

  2. Acute promyelocytic leukemia (APL) is a subset of acute myeloid leukemia (AML) which is characterized by the fusion of promyelocytic leukemia PML and retinoic acid receptor- alpha (RAR-alpha) genes. All-trans ...

    Authors: Mariam Fatima, Salik Javed Kakar, Fazal Adnan, Khalid Khan, Afsar Ali Mian and Dilawar Khan

    Citation: BMC Cancer 2021 21:713

    Content type: Research

    Published on:

  3. Esophageal and gastric cancers are a significant public health problem worldwide, with most patients presenting with advanced-stage disease and, consequently, poor prognosis. Systemic oncological treatments (S...

    Authors: M. Santero, J. Pérez-Bracchiglione, R. Acosta-Dighero, A. G. Meade, A. Antequera, A. Auladell-Rispau, M. J. Quintana, C. Requeijo, G. Rodríguez-Grijalva, K. Salas-Gama, R. Dorantes-Romandia, J. Salazar, I. Solà, G. Urrútia and X. Bonfill Cosp

    Citation: BMC Cancer 2021 21:712

    Content type: Research

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  4. This study aims to provide new insights on the role of smoking patterns and cigarette dependence in female lung cancer, and to examine differences by histological subtype.

    Authors: Jennifer Rusmaully, Nastassia Tvardik, Diane Martin, Régine Billmann, Sylvie Cénée, Martine Antoine, Hélène Blons, Pierre Laurent-Puig, Jean Trédaniel, Marie Wislez, Isabelle Stücker, Pascal Guénel and Loredana Radoï

    Citation: BMC Cancer 2021 21:711

    Content type: Research article

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  5. There is no evidence whether it is best to stop drinking alcohol at all or whether it is okay to drink a little in that light-to-moderate alcohol use was associated with low cardiovascular disease (CVD) compar...

    Authors: Gyeongsil Lee, Seogsong Jeong, Seulggie Choi, Kyae Hyung Kim, Jooyoung Chang, Seong Rae Kim, Kyuwoong Kim, Joung Sik Son, Sung Min Kim, Daein Choi and Sang Min Park

    Citation: BMC Cancer 2021 21:710

    Content type: Research

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  6. Though sepsis is common in patients with cancer, there are limited studies that evaluated sepsis and septic shock in this patient population. The objective of this study was to evaluate the outcomes and to ide...

    Authors: Wedad B. Awad, Lama Nazer, Salam Elfarr, Maha Abdullah and Feras Hawari

    Citation: BMC Cancer 2021 21:709

    Content type: Research

    Published on:

  7. In the surgical treatment of intrahepatic cholangiocarcinoma (ICC), postoperative complications may be predictive of long-term survival. This study aimed to identify an immune-nutritional index (INI) that can ...

    Authors: Tatsuo Matsuda, Yuzo Umeda, Tadakazu Matsuda, Yoshikatsu Endo, Daisuke Sato, Toru Kojima, Kenta Sui, Masaru Inagaki, Tetsuya Ota, Masayoshi Hioki, Masahiro Oishi, Masashi Kimura, Toshihiro Murata, Nobuhiro Ishido, Takahito Yagi and Toshiyoshi Fujiwara

    Citation: BMC Cancer 2021 21:708

    Content type: Research

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  8. The 21-gene recurrence score (RS) can predict chemotherapy benefit in estrogen receptor-positive, human epidermal growth factor receptor-2-negative (ER+/HER2-) early breast cancer patients. Age would influence...

    Authors: Jing Yu, Caijin Lin, Jiahui Huang, Jin Hong, Weiqi Gao, Siji Zhu, Lin Lin, Xiaosong Chen, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Jiayi Wu and Kunwei Shen

    Citation: BMC Cancer 2021 21:707

    Content type: Research article

    Published on:

  9. Epidemiological evidence suggests that synchronous or metachronous presentation of breast and thyroid cancers exceeds that predicted by chance alone. The following potential explanations have been hypothesized...

    Authors: Bence Bakos, András Kiss, Kristóf Árvai, Balázs Szili, Barbara Deák-Kocsis, Bálint Tobiás, Zsuzsanna Putz, Richárd Ármós, Bernadett Balla, János Kósa, Magdolna Dank, Zsuzsanna Valkusz, István Takács, Ádám Tabák and Péter Lakatos

    Citation: BMC Cancer 2021 21:706

    Content type: Research article

    Published on:

  10. Our previous studies have reported the down-regulation of EGFL8 correlates to the development and prognosis of colorectal and gastric cancer. The present study is carried out to explore the expression pattern ...

    Authors: Fan Wu, Fang-Yong Zhang, Guo-Qian Tan, Wei-Jia Chen, Biao Huang, Lun Yan, Hao-Lu Zhang, Shi Chen, Yang Jiao and Bai-Lin Wang

    Citation: BMC Cancer 2021 21:704

    Content type: Research

    Published on:

  11. Cancer stemness is associated with metastases in kidney renal clear cell carcinoma (KIRC) and negatively correlates with immune infiltrates. Recent stemness evaluation methods based on the absolute expression ...

    Authors: Lixing Xiao, Guoying Zou, Rui Cheng, Pingping Wang, Kexin Ma, Huimin Cao, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Yan Huang, Xiaoyu Lin, Huan Nie and Qinghua Jiang

    Citation: BMC Cancer 2021 21:703

    Content type: Research

    Published on:

  12. We conducted a single-arm phase II trial to investigate the short-term efficacy and safety of apatinib combined with oxaliplatin and S-1 in the treatment of unresectable gastric cancer.

    Authors: Zaisheng Ye, Yi Zeng, Shenghong Wei, Yi Wang, Zhitao Lin, Shu Chen, Zhiwei Wang, Shanshan Chen and Luchuan Chen

    Citation: BMC Cancer 2021 21:702

    Content type: Research

    Published on:

  13. We evaluated the treatment response and predictive factors for overall survival (OS) in patients with hepatocellular carcinoma (HCC) and portal vein tumour thrombosis (PVTT), who underwent stereotactic body ra...

    Authors: Xiaojie Li, Zhimin Ye, Sheng Lin and Haowen Pang

    Citation: BMC Cancer 2021 21:701

    Content type: Research

    Published on:

  14. Inflammation plays an important role in tumor proliferation, metastasis, and resistance to chemotherapy. The systemic inflammation response index (SIRI), has been reported to be closely related to prognosis in...

    Authors: Jie Dong, Qingqing Sun, Yueyin Pan, Nannan Lu, Xinghua Han and Qiong Zhou

    Citation: BMC Cancer 2021 21:700

    Content type: Research

    Published on:

  15. An unexpected recurrence of hepatocellular carcinoma (HCC) sometimes occurs in patients with hepatitis C virus (HCV) after treatment with direct-acting antivirals (DAAs). However, the characteristics of patien...

    Authors: Takao Watanabe, Yoshio Tokumoto, Kouji Joko, Kojiro Michitaka, Norio Horiike, Yoshinori Tanaka, Fujimasa Tada, Yoshiyasu Kisaka, Seiji Nakanishi, Kazuhiko Yamauchi, Hironori Ochi, Atsushi Hiraoka, Sen Yagi, Atsushi Yukimoto, Masashi Hirooka, Masanori Abe…

    Citation: BMC Cancer 2021 21:699

    Content type: Research article

    Published on:

  16. The number of colorectal cancer patients increases with age. The decision to go through major surgery can be challenging for the aged patient and the surgeon because of the heterogeneity within the older popul...

    Authors: Susanna Niemeläinen, Heini Huhtala, Anu Ehrlich, Jyrki Kössi, Esa Jämsen and Marja Hyöty

    Citation: BMC Cancer 2021 21:698

    Content type: Study protocol

    Published on:

  17. Gastric cancer (GC) is one of the most common solid malignant tumors worldwide with a high-recurrence-rate. Identifying the molecular signatures and specific biomarkers of GC might provide novel clues for GC p...

    Authors: Xiao-Qing Lu, Jia-Qian Zhang, Sheng-Xiao Zhang, Jun Qiao, Meng-Ting Qiu, Xiang-Rong Liu, Xiao-Xia Chen, Chong Gao and Huan-Hu Zhang

    Citation: BMC Cancer 2021 21:697

    Content type: Research article

    Published on:

  18. Abnormal expression of suppressor of cytokine signaling (SOCS) proteins regulates tumor angiogenesis and development in cancers. In this study, we aimed to perform a comprehensive bioinformatic analysis of SOC...

    Authors: Mingyu Sun, Chuangang Tang, Jun Liu, Wenli Jiang, Haifeng Yu, Fang Dong, Caiguo Huang and Youlutuziayi Rixiati

    Citation: BMC Cancer 2021 21:696

    Content type: Research article

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  19. Phase 3 oncologic randomized clinical trials (RCTs) can lead to Food and Drug Administration (FDA) approvals. In this study, we aim to identify trial-related factors associated with trials leading to subsequen...

    Authors: Joseph Abi Jaoude, Ramez Kouzy, Marc Ghabach, Roshal Patel, Dario Pasalic, Elie Ghossain, Austin B. Miller, Timothy A. Lin, Vivek Verma, C. David Fuller, Vivek Subbiah, Bruce D. Minsky, Ethan B. Ludmir and Cullen M. Taniguchi

    Citation: BMC Cancer 2021 21:695

    Content type: Research

    Published on:

  20. Liver hepatocellular carcinoma (HCC) is one of the most malignant tumors, of which prognosis is unsatisfactory in most cases and metastatic of HCC often results in poor prognosis. In this study, we aimed to co...

    Authors: Chao Chen, Yan Qun Liu, Shi Xiang Qiu, Ya Li, Ning Jun Yu, Kang Liu and Li Ming Zhong

    Citation: BMC Cancer 2021 21:693

    Content type: Research

    Published on:

  21. Patients with Philadelphia-negative Myeloproliferative Neoplasms (MPN) suffer from numerous symptoms and decreased quality of life. Smoking is associated with an increased symptom burden in several malignancie...

    Authors: Sarah F. Christensen, Robyn M. Scherber, Gina L. Mazza, Amylou C. Dueck, Nana Brochmann, Christen L. Andersen, Hans C. Hasselbalch, Ruben A. Mesa and Holly L. Geyer

    Citation: BMC Cancer 2021 21:691

    Content type: Research article

    Published on:

  22. Published findings suggest sex differences in lung cancer risk and a potential role for sex steroid hormones. Our aim was to perform a meta-analysis to investigate the effects of sex steroid hormone exposure s...

    Authors: Hui Zeng, Zhuoyu Yang, Jiang Li, Yan Wen, Zheng Wu, Yadi Zheng, Yiwen Yu, Yongjie Xu, Shugeng Gao, Fengwei Tan, Ni Li, Qi Xue and Jie He

    Citation: BMC Cancer 2021 21:690

    Content type: Research article

    Published on:

  23. Currently biomarkers play an essential role in diagnosis, treatment, and management of cancer. In non-small cell lung cancer (NSCLC) determination of biomarkers such as ALK, EGFR, ROS1 or PD-L1 is mandatory fo...

    Authors: Ernest Nadal, Dolores Bautista, Luis Cabezón-Gutiérrez, Ana Laura Ortega, Héctor Torres, David Carcedo, Lucía Ruiz de Alda, J. Francisco Garcia, Paula Vieitez and Federico Rojo

    Citation: BMC Cancer 2021 21:689

    Content type: Research article

    Published on:

  24. Low-risk human papillomavirus (HPV), such as types 6 and 11, is considered non-oncogenic, but these types have been detected in oral cancer tissue samples, suggesting their possible involvement in oral carcino...

    Authors: Karina Uehara, Yasuka Tanabe, Shintaro Hirota, Saki Higa, Zensei Toyoda, Kiyoto Kurima, Shinichiro Kina, Toshiyuki Nakasone, Akira Arasaki and Takao Kinjo

    Citation: BMC Cancer 2021 21:688

    Content type: Research article

    Published on:

  25. The baculoviral IAP repeat containing 5 (BIRC5) related to epithelial-mesenchymal transition (EMT) plays a crucial role in the pathogenesis of hepatocellular carcinoma (HCC). However, it remains unclear whethe...

    Authors: Rongzhong Xu, Liubing Lin, Bo Zhang, Jian Wang, Fanchen Zhao, Xiaolin Liu, Yiping Li and Yan Li

    Citation: BMC Cancer 2021 21:687

    Content type: Research article

    Published on:

  26. Testicular Self-Examination (TSE) causes earlier diagnosis of Testicular cancer (TC). Hence, all men aged between15 to 35 years should perform TSE every month. This study aims to survey the effect of education...

    Authors: Ali Khani Jeihooni, Hanieh Jormand, Mehdi Ansari, Pooyan Afzali Harsini and Tayebeh Rakhshani

    Citation: BMC Cancer 2021 21:685

    Content type: Research

    Published on:

  27. Access to childhood cancer medicines is a critical global health challenge. There is a lack of sufficient context-specific data in Ghana on access to essential medicines for treating childhood cancers. Here, w...

    Authors: Kofi Boamah Mensah, Adwoa Bemah Boamah Mensah, Varsha Bangalee, Neelaveni Padayachee and Frasia Oosthuizen

    Citation: BMC Cancer 2021 21:683

    Content type: Research

    Published on:

  28. We aimed to evaluate the effects of different therapeutic options to prevent the evolution of vaginal stenosis after pelvic radiotherapy in women with cervical cancer.

    Authors: Jumara Martins, Ana Francisca Vaz, Regina Celia Grion, Lúcia Costa-Paiva and Luiz Francisco Baccaro

    Citation: BMC Cancer 2021 21:682

    Content type: Research article

    Published on:

  29. Prolactin receptor (PRLR) is an attractive antibody therapeutic target with expression across a broad population of breast cancers. Antibody efficacy, however, may be limited to subtypes with either PRLR overe...

    Authors: Mark G. Anderson, Qian Zhang, Luis E. Rodriguez, Claudie M. Hecquet, Cherrie K. Donawho, Peter J. Ansell and Edward B. Reilly

    Citation: BMC Cancer 2021 21:681

    Content type: Research article

    Published on:

  30. Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or p...

    Authors: Fang Yu, Babu Gajendran, Ning Wang, Klarke M. Sample, Wuling Liu, Chunlin Wang, Anling Hu, Eldad Zacksenhaus, Xiaojiang Hao and Yaacov Ben-David

    Citation: BMC Cancer 2021 21:680

    Content type: Research article

    Published on:

  31. Information about survival by stage in bladder cancer is scarce, as well as about survival of non-invasive bladder cancer. The aims of this study are: 1) to find out the distribution of bladder cancer by stage...

    Authors: J. Ripoll, M. Ramos, J. Montaño, J. Pons, A. Ameijide and P. Franch

    Citation: BMC Cancer 2021 21:676

    Content type: Research article

    Published on:

  32. The association between SOX14 and cancer has been reported. The aim of this study was to identify and validate the potential value of SOX14 methylation in the early detection of cervical cancer.

    Authors: Jing Zhao, Huiling Cao, Wenfan Zhang, Yongjuan Fan, Shujuan Shi and Rong Wang

    Citation: BMC Cancer 2021 21:675

    Content type: Research article

    Published on:

  33. Previous clinical trials have demonstrated the potential efficacy of rechallenge with anti- epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) for patients with RAS/BRAF V600E wild-type metastat...

    Authors: Hiromichi Nakajima, Daisuke Kotani, Hideaki Bando, Takeshi Kato, Eiji Oki, Eiji Shinozaki, Yu Sunakawa, Kentaro Yamazaki, Satoshi Yuki, Yoshiaki Nakamura, Takeharu Yamanaka, Takayuki Yoshino, Takashi Ohta, Hiroya Taniguchi and Yoshinori Kagawa

    Citation: BMC Cancer 2021 21:674

    Content type: Study protocol

    Published on:

  34. miRNAs and lncRNAs can regulate cellular biological processes both under physiological and pathological conditions including tumour initiation and progression. Interactions between differentially expressed div...

    Authors: Brigitta László, László Antal, Eszter Gyöngyösi, Anita Szalmás, Szilárd Póliska, György Veress and József Kónya

    Citation: BMC Cancer 2021 21:673

    Content type: Research article

    Published on:

  35. Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that lack of effective therapeutic drugs. K-001 is an oral antitumor drug made from active ingredients of marine microorganisms. The current study ai...

    Authors: Jiujie Cui, Haiyan Yang, Jue Liu, Donghui Chen, Jiong Hu, Haiyan Zhang, Yu Wang, Ting Han, Tiebo Mao, Feng Jiao, Ewelina Biskup, Yaotian Pan, Min Liu and Liwei Wang

    Citation: BMC Cancer 2021 21:672

    Content type: Research article

    Published on:

  36. Integrated social care may help to mitigate social risk factors in order to achieve more equitable health outcomes. In cancer centers certified according to the criteria set out by the German Cancer Society, e...

    Authors: Clara Breidenbach, Simone Wesselmann, Nora Tabea Sibert, Olaf Ortmann, Katrin Blankenburg, Cindy Stoklossa, Gerhard Gebauer, Marina dos Santos Guilherme, Christoph Lindner, Susanne Peschel, Friedemann Schad, Paul Strecker, Lorenz Rieger, Julia Ferencz, Sebastian Dieng and Christoph Kowalski

    Citation: BMC Cancer 2021 21:671

    Content type: Research article

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  37. The second most common cancer among females in Bangladesh is cervical cancer. The national strategy for cervical cancer needs monitoring to ensure that patients have access to care. In order to provide accurat...

    Authors: Shagoofa Rakhshanda, Koustuv Dalal, Hasina Akhter Chowdhury, Cinderella Akbar Mayaboti, Progga Paromita, A. K. M. Fazlur Rahman, A. H. M. Eanayet Hussain and Saidur Rahman Mashreky

    Citation: BMC Cancer 2021 21:670

    Content type: Research article

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  38. Patients diagnosed with Barcelona Clinic Liver Cancer (BCLC) intermediate stage hepatocellular carcinoma (HCC) encompass a broad clinical population. Kinki criteria subclassifications have been proposed to bet...

    Authors: Masateru Yamamoto, Tsuyoshi Kobayashi, Masakazu Hashimoto, Shintaro Kuroda, Tomokazu Kawaoka, Hiroshi Aikata, Kazuaki Chayama and Hideki Ohdan

    Citation: BMC Cancer 2021 21:668

    Content type: Research

    Published on:

  39. Cervical cancer is one of the most common malignancies among women. Appropriate and timely treatment of these patients can reduce the complications and increase their survival. The objective of this study was ...

    Authors: Setareh Akhavan, Abbas Alibakhshi, Mahdieh Parsapoor, Abbas Alipour and Elahe Rezayof

    Citation: BMC Cancer 2021 21:667

    Content type: Research

    Published on:

  40. Early-stage non-small lung cancer patients may survive long enough to develop second primary lung cancers. However, few studies have accurately described the therapeutic method, evaluation or prognostic factor...

    Authors: Congcong Chen, Zixiang Wu, Ziheng Wu, Chuanqiang Wu, Qi Wang, Tianwei Zhan, Lingjun Dong, Shuai Fang and Ming Wu

    Citation: BMC Cancer 2021 21:666

    Content type: Research

    Published on:

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