Fibronectin (FN) is a high-molecular-weight glycoprotein component of the extracellular matrix involved in cell adhesion, migration, metastasis, proliferation and differentiation, as well as embryogenesis, wou...
Authors: Jiefei Xiao, Weilin Yang, Bo Xu, Haoshuai Zhu, Jianyong Zou, Chunhua Su, Jian Rong, Tao Wang and Zhenguang Chen
In our previous study, colorectal cancer (CRC) patients with active Mycobacterium tuberculosis (MTB) tolerated concurrent anti-cancer chemotherapy (anti-CCT) and anti-MTB chemotherapy. In this study, we retrospec...
Adjuvant endocrine therapy undoubtedly prolongs the time to recurrence for patients with hormone-positive early breast cancer. Extended endocrine therapy to 10 years or longer has been expected to bring a grea...
Authors: Li Li, Bingmei Chang, Xiaoyue Jiang, Xueke Fan, Yingrui Li, Teng Li, Shanshan Wu, Jun Zhang, Seyed Kariminia and Qin Li
We developed a novel plasma amino acid profile-based index (API) to detect ovarian, uterine, cervical, and endometrial cancers. In this study, we aimed to evaluate whether abnormal API values could be normaliz...
Authors: Yukio Suzuki, Aya Tokinaga-Uchiyama, Taichi Mizushima, Yasuyo Maruyama, Tae Mogami, Nahoko Shikata, Atsuko Ikeda, Hiroshi Yamamoto and Etsuko Miyagi
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for mucinous cystic neoplasm of the pancreas carries a potential risk of inducing peritoneal tumor cell dissemination. We investigated the diagnost...
Authors: Rei Suzuki, Hiroki Irie, Tadayuki Takagi, Mitsuru Sugimoto, Naoki Konno, Yuki Sato, Ko Watanabe, Jun Nakamura, Shigeru Marubashi, Takuto Hikichi and Hiromasa Ohira
Epidermal growth factor receptor (EGFR) gene alterations and amplification are frequently reported in cases of glioblastoma (GBM). However, EGFR-activating mutations that confer proven sensitivity to tyrosine kin...
Authors: Lea Loriguet, Mony Chenda Morisse, Julie Dremaux, Louison Collet, Christophe Attencourt, Alexandre Coutte, Mathieu Boone, Henri Sevestre, Antoine Galmiche, Brigitte Gubler, Bruno Chauffert and Stephanie Trudel
Conventional chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC) however it increases therapeutic resistance. In contrast, metronomic chemotherapy (MET) is based on frequent drug administ...
Authors: Rong-Sheng Qin, Zhen-Hua Zhang, Neng-Ping Zhu, Fei Chen, Qian Guo, Hao-Wen Hu, Shao-Zhi Fu, Shan-Shan Liu, Yue Chen, Juan Fan and Yun-Wei Han
Prior small studies have shown increased expression of sperm protein 17 (Sp17) in epithelial ovarian cancer (EOC) tissue and suggest Sp17 as a potential biomarker for EOC. However, how Sp17 expression varies w...
Authors: Laurie L. Brunette, Paulette Y. Mhawech-Fauceglia, Lingyun Ji, Joseph G. Skeate, Heike E. Brand, Kate Lawrenson, Saloni Walia, Maurizio Chiriva-Internati, Susan Groshen, Lynda D. Roman, W. Martin Kast and Diane M. Da Silva
Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to t...
Authors: Alex J Eustace, Neil T Conlon, Martina S J McDermott, Brigid C Browne, Patrick O’Leary, Frankie A Holmes, Virginia Espina, Lance A Liotta, Joyce O’Shaughnessy, Clair Gallagher, Lorraine O’Driscoll, Sweta Rani, Stephen F Madden, Neil A O’Brien, Charles Ginther, Dennis Slamon…
We report here a correlation analysis conducted along with a phase II trial assessing bevacizumab in combination with weekly paclitaxel.
Authors: Loïc Lebellec, François Bertucci, Emmanuelle Tresch-Bruneel, Isabelle Ray-Coquard, Axel Le Cesne, Emmanuelle Bompas, Jean-Yves Blay, Antoine Italiano, Olivier Mir, Thomas Ryckewaert, Yves Toiron, Luc Camoin, Anthony Goncalves, Nicolas Penel and Marie-Cécile Le Deley
Cancer/testis antigen MAGEC2 (also known as HCA587) is highly expressed in a wide variety of tumors and plays an active role in promoting growth and metastasis of tumor cells. However, little is known for the ...
Authors: Xiao Song, Chengli Guo, Yutian Zheng, Ying Wang, Zhongtian Jin and Yanhui Yin
Decrease in bone mineral density, osteoporosis development, bone toxicity and resulting insufficiency fractures as late effect of radiotherapy are not well known. Osteoporosis development related to radiothera...
The current TNM staging system is far from perfect in predicting the survival of individual non-small cell lung cancer (NSCLC) patients. In this study, we aim to combine clinical variables and molecular biomar...
Authors: Lei Liu, Minxin Shi, Zhiwei Wang, Haimin Lu, Chang Li, Yu Tao, Xiaoyan Chen and Jun Zhao
Gastric gastrointestinal stromal tumor (GIST), intro-abdominal and retroperitoneal neoplasms are distinct tumors arising from different cell layers; therefore, coexistence of such tumors is relatively rare.
Authors: Yong Zhou, Xu-Dong Wu, Quan Shi, Chuan-hai Xu and Jing Jia
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) has been proposed in head and neck squamous cell carcinoma (HNSCC). However, it is currently unclear which cutoff values of NLR could consistently an...
Authors: Jae-Keun Cho, Myoung Woo Kim, Ick Soo Choi, Uk Yeol Moon, Min-Ji Kim, Insuk Sohn, Seonwoo Kim and Han-Sin Jeong
The cellular effects of androgen are transduced through the androgen receptor, which controls the expression of genes that regulate biosynthetic processes, cell growth, and metabolism. Androgen signaling also ...
Authors: Kasey Jividen, Katarzyna Z Kedzierska, Chun-Song Yang, Karol Szlachta, Aakrosh Ratan and Bryce M Paschal
The use of stereotactic body radiotherapy (SBRT) for early-stage primary non-small cell lung cancer (NSCLC) reported excellent local control rates. But the optimal SBRT dose for oligometastatic lung tumors (OL...
Authors: Xin Wang, Leonid Zamdborg, Hong Ye, Inga S. Grills and Di Yan
Gastrointestinal symptoms occur in approximately 50% of patients with systemic lupus erythematous with low specificity. Although it is well established that colon cancer is one of the many gastrointestinal man...
Chemotherapy-induced oral mucositis impairs the quality of life. The difference in severity of oral mucositis between different anti-epidermal growth factor receptor (EGFR) antibodies combined with cytotoxic d...
The prognosis of patients with epidermal growth factor receptor (EGFR) mutant adenocarcinoma of the lung (Mt) and EGFR wild-type adenocarcinoma (Wt) after complete resection of the lung differ; however, the mecha...
Paclitaxel induced peripheral neuropathy (PIPN) is a major debilitating side effect of paclitaxel in patients with breast cancer with no fully known mechanisms. The aim of the study was to find out the possibl...
Authors: Zohreh Ghoreishi, Seyedali Keshavarz, Mohammad Asghari Jafarabadi, Zahra Fathifar, Karyn A Goodman and Ali Esfahani
FIGHTDIGO study showed the feasibility and acceptability of handgrip strength (HGS) measure in routine in 201 consecutive patients with digestive cancer treated with ambulatory chemotherapy. The present study ...
Authors: Damien Botsen, Marie-Amélie Ordan, Coralie Barbe, Camille Mazza, Marine Perrier, Johanna Moreau, Mathilde Brasseur, Yohann Renard, Barbara Taillière, Florian Slimano, Eric Bertin and Olivier Bouché
Patients’ quality of life has become a major objective of care in oncology. At the same time, it has become the object of increasing interest by researchers, working with both quantitative and qualitative meth...
Authors: Jordan Sibeoni, Camille Picard, Massimiliano Orri, Mathilde Labey, Guilhem Bousquet, Laurence Verneuil and Anne Revah-Levy
Many studies have shown that lifestyle factors such as diet, physical activity are related to the incidence of cancer. However, there are few studies on the association between lifestyle factors and cancer pro...
Authors: Yuri Mizota, Yukihide Kanemitsu, Shunsuke Tsukamoto, Dai Shida, Hiroki Ochiai and Seiichiro Yamamoto
Oligometastases refer to a state of disease where cancer has spread beyond the primary site, but is not yet widely metastatic, often defined as 1–3 or 1–5 metastases in number. Stereotactic ablative radiothera...
Authors: Robert Olson, Mitchell Liu, Alanah Bergman, Sonya Lam, Fred Hsu, Benjamin Mou, Tanya Berrang, Ante Mestrovic, Nick Chng, Derek Hyde, Quinn Matthews, Chad Lund, Daniel Glick, Howard Pai, Parminder Basran, Hannah Carolan…
In the last decade, several tyrosine kinase inhibitors (TKIs), which disrupt pathways involved in the proliferation and tumorigenesis of thyroid cancer, have been extensively studied. Two different TKIs, lenva...
Authors: Soo Young Kim, Seok-Mo Kim, Ho-Jin Chang, Bup-Woo Kim, Yong Sang Lee, Cheong Soo Park, Ki Cheong Park and Hang-Seok Chang
The transcribed ultraconserved regions (T-UCRs) are a novel class of non-coding RNAs that are absolutely conserved across species and are involved in carcinogenesis in some cancers. However, the expression and...
Authors: Yohei Sekino, Naoya Sakamoto, Keisuke Goto, Ririno Honma, Yoshinori Shigematsu, Thang Pham Quoc, Kazuhiro Sentani, Naohide Oue, Jun Teishima, Fumi Kawakami, Jose A Karam, Kanishka Sircar, Akio Matsubara and Wataru Yasui
This study assessed the health related quality of life of family caregivers (FCs) of leukemia patients by using the health utility scores derived from the EuroQol five-dimensional (EQ-5D) questionnaire.
Authors: Hongjuan Yu, Huan Zhang, Jinjin Yang, Chaojie Liu, Chengfang Lu, Hongbin Yang, Weidong Huang, Jin Zhou, Wenqi Fu, Linmei Shi, Yan Yan, Guoxiang Liu and Limin Li
Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural dev...
Authors: Sophie Elena McGrath, Nicola Annels, Thumuluru K. Madhuri, Anil Tailor, Simon A. Butler-Manuel, Richard Morgan, Hardev Pandha and Agnieszka Michael
The safety of laparoscopic total gastrectomy (LTG) for the treatment of gastric cancer remains lack of clinical evidence. The Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group recently launched...
The analysis of tumour-infiltrating immune cells within patients’ tumour samples in colorectal cancer (CRC) has become an independent predictor of patient survival. The tumour microenvironment and the immune c...
Authors: Ramón Cantero-Cid, José Casas-Martin, Enrique Hernández-Jiménez, Carolina Cubillos-Zapata, Aníbal Varela-Serrano, José Avendaño-Ortiz, Marta Casarrubios, Karla Montalbán-Hernández, Ignacio Villacañas-Gil, Laura Guerra-Pastrián, Begoña Peinado, Cristóbal Marcano, Luis A Aguirre and Eduardo López-Collazo
Survival of esophageal cancer in Linzhou was seen to increase over the past few decades and is higher than the average level of China due to the implementation of comprehensive prevention and control measures....
Authors: Shuzheng Liu, Lanwei Guo, Qiong Chen, Liang Yu, Bianyun Li, Xiaoqin Cao and Xibin Sun
The rs2147578 C > G polymorphism in the long non-coding RNA gene Lnc-LAMC2–1:1 is associated with increased susceptibility to a few types of cancers. However, its role in neuroblastoma has not been evaluated yet.
Authors: Tianyou Yang, Zhuorong Zhang, Jiao Zhang, Tianbao Tan, Jiliang Yang, Jing Pan, Chao Hu, Jiahao Li, Huimin Xia, Jing He and Yan Zou
Immune checkpoint inhibitors (ICIs) have emerged as promising therapeutic agents in non-small cell lung cancer (NSCLC). However, the duration for which ICIs should be continued remains a clinical problem.
Chronic active Epstein-Barr virus (EBV) infection (CAEBV) of the T-/NK-cell type, systemic form is a rare and potentially life-threatening illness caused by persistent EBV infection. The highest incidence is f...
Authors: Maxi Wass, Marcus Bauer, Roald Pfannes, Kerstin Lorenz, Andreas Odparlik, Lutz P Müller and Claudia Wickenhauser
Coagulation and nutrition play important roles in cancer progression. The aim of the present study is to evaluate the prognostic value of the preoperative fibrinogen/albumin ratio (FAR) in surgical patients wi...
Authors: Yao Liang, Wei Wang, Yi Que, Yuanxiang Guan, Wei Xiao, Cheng Fang, Xing Zhang and Zhiwei Zhou
Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting p...
Authors: András Folyovich, Viktória Varga, György Várallyay, Lajos Kozák, Mária Bakos, Erika Scheidl, Katalin Anna Béres-Molnár, Zita Kajdácsi and Dániel Bereczki
Clonal VDJ rearrangement of B/T cell receptors (B/TCRs) occurring during B/T lymphocyte development has been used as a marker to track the clonality of B/T cell populations.
Authors: Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda, De-Chen Lin, Henry Yang and H. Phillip Koeffler
In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of an aggressive tumour phen...
Authors: Krzysztof Marek Mrozik, Orest William Blaschuk, Chee Man Cheong, Andrew Christopher William Zannettino and Kate Vandyke
Carcinogenesis and tumor growth are associated with chronic inflammation and the host immune system. Here, we investigated the clinical significance and relationship between tumor-infiltrating lymphocytes (TIL...
Authors: Kwan Ho Lee, Eun Young Kim, Ji Sup Yun, Yong Lai Park, Sung-Im Do, Seoung Wan Chae and Chan Heun Park
The tyrosine kinase inhibitor pazopanib is used for treatment of sarcoma. Recent studies have suggested that the use of pazopanib may lead to the development of pneumothorax, an unexpected adverse effect in pa...
Authors: Bruce Sabath, Hasan A Muhammad, Amulya Balagani, David E Ost, Erik Vakil, Tahreem Ahmed, Macarena R Vial and Horiana B Grosu
Breast cancer related lymphoedema (BCRL) occurs in a substantial proportion of breast cancer survivors and is a major contributor to patients’ disability. Regrettably, there are no validated predictive biomark...
Authors: Marco Invernizzi, Chiara Corti, Gianluca Lopez, Anna Michelotti, Luca Despini, Donatella Gambini, Daniele Lorenzini, Elena Guerini-Rocco, Stefania Maggi, Marianna Noale and Nicola Fusco
Cancer research has made great progress in the recent years. With the increasing number of options in diagnosis and therapy the implementation of tumorboards (TUBs) has become standard procedure in the treatme...
Authors: S. Hollunder, U. Herrlinger, M. Zipfel, J. Schmolders, V. Janzen, T. Thiesler, E. Güresir, A. Schröck, F. Far, T. Pietsch, D. Pantelis, D. Thomas, S. Vornholt, N. Ernstmann, T. Manser, M. Neumann…
Several trials evaluated the role of ovarian function suppression for the adjuvant treatment of premenopausal patients with hormone receptor-positive early breast cancer. Based on the results of the SOFT and T...
Authors: Giacomo Pelizzari, Grazia Arpino, Laura Biganzoli, Saverio Cinieri, Michelino De Laurentiis, Lucia Del Mastro, Angelo Di Leo, Stefania Gori, Valentina Guarneri, Paolo Marchetti and Fabio Puglisi
Organizations that issue guidance on breast cancer recommend the use of immunohistochemistry (IHC) for providing appropriate and precise care. However, little focus has been directed to the identification of m...
Authors: Arturo López-Pineda, Mario F Rodríguez-Moran, Cleto Álvarez-Aguilar, Sarah M Fuentes Valle, Román Acosta-Rosales, Ami S Bhatt, Shruti N Sheth and Carlos D Bustamante
Several intervention studies have demonstrated that exercise training has beneficial effects among cancer patients. However, older cancer patients are underrepresented in clinical trials, and only few exercise...
Authors: Marta Kramer Mikkelsen, Cecilia Margareta Lund, Anders Vinther, Anders Tolver, Anne-Mette Ragle, Julia Sidenius Johansen, Inna Chen, Lotte Engell-Noerregaard, Finn Ole Larsen, Bo Zerahn, Dorte Lisbet Nielsen and Mary Jarden
Initial primary colorectal cancer (IPCRC) has a high risk of developing into second primary colorectal cancer (SPCRC). Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) have different characteri...
Authors: Lin Yang, Zhenchong Xiong, Qian Kun Xie, Wenzhuo He, Shousheng Liu, Pengfei Kong, Chang Jiang, Xiaojun Xia and Liangping Xia
Chimeric antigen receptor T (CAR T) cells immunotherapy is rapidly developed in treating cancers, especially relapsed or refractory B-cell malignancies.
Authors: Hui Zhou, Yuling Luo, Sha Zhu, Xi Wang, Yunuo Zhao, Xuejin Ou, Tao Zhang and Xuelei Ma
Breast cancer is the most common cancer in women. 12–15% of all tumors are triple-negative breast cancers (TNBC). So far, TNBC has been mainly associated with mutations in BRCA1. The presence of other predispo...
Authors: Juliane Hoyer, Georgia Vasileiou, Steffen Uebe, Marius Wunderle, Cornelia Kraus, Peter A. Fasching, Christian T. Thiel, Arndt Hartmann, Matthias W. Beckmann, Michael P. Lux and André Reis
Cervical cancer incidence and mortality is high in Uyghur ethnics. Their life style and dietary habit were different from other ethnics living together. Study on the role of trace elements in HPV infection and...
