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  1. Circular RNAs (circRNAs) have emerged as a novel category of non-coding RNA, which exhibit a pivotal effect on regulating gene expression and biological functions, yet how circRNAs function in osteosarcoma (OS...

    Authors: Houkun Li, Limin He, Yuan Tuo, Yansheng Huang and Bing Qian

    Citation: BMC Cancer 2020 20:1026

    Content type: Research article

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  2. During 2013 and 2016 the region of Skåne, Sweden started to analyse human papillomavirus (HPV) and cytology in postmenopausal women 60–65 years of age. Our aim was to evaluate high-risk (HR) HPV mRNA testing f...

    Authors: Katrin Christine Asciutto, Christer Borgfeldt and Ola Forslund

    Citation: BMC Cancer 2020 20:1025

    Content type: Research article

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  3. For most patients, pancreatic adenocarcinoma responds poorly to treatment, and novel therapeutic approaches are needed. Standard-of-care paclitaxel (PTX), combined with birinapant (BRP), a bivalent mimetic of ...

    Authors: Jin Niu, Xue Wang, Jun Qu, Donald E. Mager and Robert M. Straubinger

    Citation: BMC Cancer 2020 20:1024

    Content type: Research article

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  4. This study proposes a prediction model for the automatic assessment of lung cancer risk based on an artificial neural network (ANN) with a data-driven approach to the low-dose computed tomography (LDCT) standa...

    Authors: Yin-Chen Hsu, Yuan-Hsiung Tsai, Hsu-Huei Weng, Li-Sheng Hsu, Ying-Huang Tsai, Yu-Ching Lin, Ming-Szu Hung, Yu-Hung Fang and Chien-Wei Chen

    Citation: BMC Cancer 2020 20:1023

    Content type: Research article

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  5. Both intermittent intravenous (IIV) infusion and continuous intravenous (CIV) infusion of Endostar are widely used for NSCLC in China. We aimed to compare the efficacy and safety of CIV of Endostar versus IIV ...

    Authors: Bo Wang, Lu Xu, Qihuan Li, Sailimai Man, Cheng Jin, Lian Liu, Siyan Zhan and Yi Ning

    Citation: BMC Cancer 2020 20:1021

    Content type: Research article

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  6. Loss of the genomic stability jeopardize genome stability and promote malignancies. A fraction of ovarian cancer (OvCa) arises from pathological mutations of DNA repair genes that result in highly mutagenic ge...

    Authors: Liang Song, Zizhi Tang, Changsheng Peng, Yueming Yang, Chang Guo, Danqing Wang, Liandi Guo, Jie Chen and Cong Liu

    Citation: BMC Cancer 2020 20:1020

    Content type: Research article

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  7. The downregulation of microRNA (miR)-451a has been reported in bladder cancer (BCa) tissues. Herein, we elucidated the role of miR-451a in BCa with the involvement of DNA methyltransferase 3B (DNMT3B).

    Authors: Beibei Liu, Wei Sun, Wuyue Gao, Liqiang Li, Zhenxue Cao, Xiaohuai Yang, Jianmin Liu and Yuanyuan Guo

    Citation: BMC Cancer 2020 20:1019

    Content type: Research article

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  8. The association between immune-related adverse events (irAEs) and survival outcomes in patients with advanced melanoma receiving therapy with immune checkpoint inhibitors (ICIs) has not been well established, ...

    Authors: Chiao-En Wu, Chan-Keng Yang, Meng-Ting Peng, Pei-Wei Huang, Ching-Fu Chang, Kun-Yun Yeh, Chun-Bing Chen, Chih-Liang Wang, Chao-Wei Hsu, I-Wen Chen, Cheng-Tao Lin, Shir-Hwa Ueng, Gigin Lin, Yu-Fen Lin, Chi-Yuan Cheng and John Wen-Cheng Chang

    Citation: BMC Cancer 2020 20:1018

    Content type: Research article

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  9. Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology has shed light on the clinical evolution of this ...

    Authors: Adrián Mosquera Orgueira, José Ángel Díaz Arias, Miguel Cid López, Andrés Peleteiro Raíndo, Beatriz Antelo Rodríguez, Carlos Aliste Santos, Natalia Alonso Vence, Ángeles Bendaña López, Aitor Abuín Blanco, Laura Bao Pérez, Marta Sonia González Pérez, Manuel Mateo Pérez Encinas, Máximo Francisco Fraga Rodríguez and José Luis Bello López

    Citation: BMC Cancer 2020 20:1017

    Content type: Research article

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  10. Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be us...

    Authors: Manthan Patel, Divyesh Patel, Subhamoy Datta and Umashankar Singh

    Citation: BMC Cancer 2020 20:1016

    Content type: Technical advance

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  11. Immune-related genes is closely related to the occurrence and prognosis of head and neck squamous cell carcinoma (HNSCC). At the same time, immune-related genes have great potential as prognostic markers in ma...

    Authors: Fujun Zhang, Yu Liu, Yixin Yang and Kai Yang

    Citation: BMC Cancer 2020 20:1015

    Content type: Research article

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  12. Peritoneal metastasis (PM) in gastric cancer (GC) is characterized by diffusely infiltrating and proliferating cancer cells accompanied by extensive stromal fibrosis in the peritoneal space. The prognosis of G...

    Authors: Daisuke Fujimori, Jun Kinoshita, Takahisa Yamaguchi, Yusuke Nakamura, Katsuya Gunjigake, Takashi Ohama, Koichi Sato, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Tetsuo Ohta and Sachio Fushida

    Citation: BMC Cancer 2020 20:1014

    Content type: Research article

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  13. In recent years, the differences between left-sided colon cancer (LCC) and right-sided colon cancer (RCC) have received increasing attention due to the clinicopathological variation between them. However, some...

    Authors: Yimei Jiang, Xiaowei Yan, Kun Liu, Yiqing Shi, Changgang Wang, Jiele Hu, You Li, Qinghua Wu, Ming Xiang and Ren Zhao

    Citation: BMC Cancer 2020 20:1012

    Content type: Research article

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  14. About 85% of breast cancer patients attending Komfo Anokye Teaching Hospital (KATH), Ghana, present with stage III/IV disease. In spite of great investments into the early diagnosis and management of breast ca...

    Authors: Anita Eseenam Agbeko, Joshua Arthur, Jonathan Bayuo, Basil Benduri Kaburi and Ishmael Kyei

    Citation: BMC Cancer 2020 20:1011

    Content type: Research article

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  15. Dynapenia is defined as an age-related loss of muscle strength. There is little information on dynapenia in cancer patients and on how it relates to anthropometric variables. The aim of this study was to analy...

    Authors: Ana Beatriz Rechinelli, Isabele Lessa Marques, Eduarda Cristina Rodrigues de Morais Viana, Isadora da Silva Oliveira, Vanusa Felício de Souza, Glenda Blaser Petarli, Jose Luiz Marques Rocha and Valdete Regina Guandalini

    Citation: BMC Cancer 2020 20:1010

    Content type: Research article

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  16. Epithelial ovarian cancer (EOC) is rare in women of reproductive age and fertility-sparing surgery (FSS) may be applied in early stages. The purpose of this study was to investigate the safety and efficacy of ...

    Authors: Gry Johansen, Pernilla Dahm-Kähler, Christian Staf, Angelique Flöter Rådestad and Kenny A. Rodriguez-Wallberg

    Citation: BMC Cancer 2020 20:1009

    Content type: Research article

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  17. Alternatively-activated macrophages (AAMs), an anti-inflammatory macrophage subpopulation, have been implicated in the progression of high grade serous ovarian carcinoma (HGSOC). Increased levels of AAMs are c...

    Authors: Kaitlin C. Fogg, Andrew E. Miller, Ying Li, Will Flanigan, Alyssa Walker, Andrea O’Shea, Christina Kendziorski and Pamela K. Kreeger

    Citation: BMC Cancer 2020 20:1008

    Content type: Research article

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  18. The positive response and the clinical usefulness of 14 serum antibodies in patients with esophageal squamous cell carcinoma (ESCC) were examined in this study. The Cancer Genome Atlas (TCGA) was used to inves...

    Authors: Isamu Hoshino, Yoshihiro Nabeya, Nobuhiro Takiguchi, Hisashi Gunji, Fumitaka Ishige, Yosuke Iwatate, Akiko Kuwajima, Fumiaki Shiratori, Rei Okada and Hideaki Shimada

    Citation: BMC Cancer 2020 20:1007

    Content type: Research article

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  19. The aim of this study was to explore the utility of circulating free DNA (cfDNA) in the evaluation of clinical tumor burden and survival in Chinese patients with metastatic colorectal cancer (mCRC) and to prel...

    Authors: Xiaojing Xu, Yiyi Yu, Minna Shen, Mengling Liu, Shengchao Wu, Li Liang, Fei Huang, Chenlu Zhang, Wei Guo and Tianshu Liu

    Citation: BMC Cancer 2020 20:1006

    Content type: Research article

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  20. An increasing number of studies have reported circular RNAs (circRNAs) as new potential biomarkers for the prognosis of gliomas. However, the overall prognostic value of circRNAs for glioma remains unclear. Th...

    Authors: Xiangqian Ding, Luyao Yang, Xin Geng, Yanghong Zou, Zhigang Wang, Yao Li, Renli Qi, Wei Wang, Jinghui Li and Hualin Yu

    Citation: BMC Cancer 2020 20:1005

    Content type: Research article

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  21. Baseline cardiovascular disease (CVD) can impact the patterns of treatment and hence the outcomes of patients with lung cancer. This study aimed to characterize treatment trends and survival outcomes of patien...

    Authors: Atul Batra, Dropen Sheka, Shiying Kong and Winson Y. Cheung

    Citation: BMC Cancer 2020 20:1004

    Content type: Research article

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  22. Increasing studies indicated that microRNA-203 (miR-203) may play an important part in the prognosis of CRC. Nevertheless, the prognostic and influential mechanism of miR-203 expression in CRC remains to be in...

    Authors: Qiliang Peng, Yi Shen, Peifeng Zhao, Shang Cai, Zhengyang Feng, Ming Cheng, Yongyou Wu and Yaqun Zhu

    Citation: BMC Cancer 2020 20:1003

    Content type: Research article

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  23. The relationship between sarcopenia and the prognoses of patients with gastric neuroendocrine neoplasms (g-NENs) is unclear. This study was designed to explore the effects of sarcopenia on short-term and long-...

    Authors: Jia-bin Wang, Zhen Xue, Jun Lu, Qing-liang He, Zhi-fang Zheng, Bin-bin Xu, Jian-wei Xie, Ping Li, Yu Xu, Jian-xian Lin, Qi-yue Chen, Long-long Cao, Mi Lin, Ru-hong Tu, Ze-ning Huang, Ju-li Lin…

    Citation: BMC Cancer 2020 20:1002

    Content type: Research article

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  24. Histone deacetylase inhibitors (HDACIs) have distinctive epigenetic targets involved in hepatocarcinogenesis and chemoresistance. A recent phase I/II study reported the possibility of HDACI as a chemosensitize...

    Authors: Young Chang, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim and Jung-Hwan Yoon

    Citation: BMC Cancer 2020 20:1001

    Content type: Research article

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  25. MCM5 is a protein involved in DNA replication, facilitating cell proliferation. In normal epithelium MCM5 expression is restricted to the cells in the basal proliferative compartments, however in the presence ...

    Authors: J. Stockley, R. Akhand, A. Kennedy, C. Nyberg, E. J. Crosbie and R. J. Edmondson

    Citation: BMC Cancer 2020 20:1000

    Content type: Research article

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  26. Cervical cancer is the second-most common gynecological cancer, early screening plays a key role in the diagnosis and treatment of cervical intraepithelial neoplasia (CIN). Sustained E7 protein expression is t...

    Authors: Linghua Kong, Xiaoping Xiao, Huiping Lou, Pengfei Liu, Shuhui Song, Moudu Liu, Tao Xu, Ying Zhang, Caijuan Li, Ruoli Guan, Yan Li, Xin Yu, Haiyuan Liu, Qingbo Fan, Honghui Shi and Lan Zhu

    Citation: BMC Cancer 2020 20:999

    Content type: Research article

    Published on:

  27. Triple-negative breast cancer (TNBC), in part because of the high metastasis rate, is one of the most prevalent causes of malignancy-related mortality globally. Ubiquitin specific peptidase 6 N-terminal like (...

    Authors: Teng Ma, Huaidong Liu, Yan Liu, Tingting Liu, Hui Wang, Fulu Qiao, Lu Song and Lin Zhang

    Citation: BMC Cancer 2020 20:998

    Content type: Research article

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  28. Successful local therapy for oligometastases may lead to longer survival. The purpose of this multicentre retrospective study was to investigate factors affecting the local control (LC) of pulmonary oligometas...

    Authors: Takaya Yamamoto, Yuzuru Niibe, Masahiko Aoki, Takashi Shintani, Kazunari Yamada, Mitsuru Kobayashi, Hideomi Yamashita, Masatoki Ozaki, Yoshihiko Manabe, Hiroshi Onishi, Katsuya Yahara, Atsushi Nishikawa, Kuniaki Katsui, Ryoong-Jin Oh, Atsuro Terahara and Keiichi Jingu

    Citation: BMC Cancer 2020 20:997

    Content type: Research article

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  29. Angiogenesis is important for the progression of gastric cancer (GC). Y-box binding protein 1 (YB-1) predicts advanced disease and indicates neovasculature formation in GC tissues, while the related mechanisms...

    Authors: Xiaoxia Xue, Jin Huang, Kai Yu, Xinyue Chen, Yini He, Dianjun Qi and Ying Wu

    Citation: BMC Cancer 2020 20:996

    Content type: Research article

    Published on:

  30. Historically, amputation was the primary surgical treatment for osteosarcoma of the extremities; however, with advancements in surgical techniques and chemotherapies limb salvage has replaced amputation as the...

    Authors: Daniel R. Evans, Alexander L. Lazarides, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer III, Brian E. Brigman and William C. Eward

    Citation: BMC Cancer 2020 20:995

    Content type: Research article

    Published on:

  31. The BRCA mutation (BRCAm) in males has been reported to confer a higher risk for the development of various tumors. However, little is known about its clinicopathologic features and prognostic implications.

    Authors: Peng Sun, Yue Li, Xue Chao, Jibin Li, Rongzhen Luo, Mei Li and Jiehua He

    Citation: BMC Cancer 2020 20:994

    Content type: Research article

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  32. Increasing evidence indicates that the pathology and the modified Kadish system have some influence on the prognosis of esthesioneuroblastoma (ENB). However, an accurate system to combine pathology with a modi...

    Authors: Lijie Jiang, Tengjiao Lin, Yu Zhang, Wenxiang Gao, Jie Deng, Zhaofeng Xu, Xin Luo, Zhaoqi Huang, Fenghong Chen, Jianbo Shi and Yinyan Lai

    Citation: BMC Cancer 2020 20:993

    Content type: Research article

    Published on:

  33. Treatment with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) is a well-established therapy for advanced Hodgkin’s lymphoma (HL). However, the recently completed ECHELON-1 trial showed potential n...

    Authors: A. J. N. Raymakers, S. Costa, D. Cameron and D. A. Regier

    Citation: BMC Cancer 2020 20:992

    Content type: Research article

    Published on:

  34. The aim of this study was to determine the safety and efficacy of fractionated stereotactic radiotherapy (SRT) in combination with systemic therapies (ST) for brain metastases (BM).

    Authors: Morgan Guénolé, François Lucia, Vincent Bourbonne, Gurvan Dissaux, Emmanuelle Reygagne, Gaëlle Goasduff, Olivier Pradier and Ulrike Schick

    Citation: BMC Cancer 2020 20:991

    Content type: Research article

    Published on:

  35. In this study, we analyze the cost-effectiveness of fruquintinib as third-line treatment for patients with metastatic colorectal cancer in China, especially after a recent price drop suggested by the National ...

    Authors: Zhi Peng, Xingduo Hou, Yangmu Huang, Tong Xie and Xinyang Hua

    Citation: BMC Cancer 2020 20:990

    Content type: Research article

    Published on:

  36. Increasing studies have demonstrated that activated platelets play an essential role in tumour progression. However, the level and prognostic role of platelet indices in chordoma patients remain unclear. The a...

    Authors: Mingxuan Li, Jiwei Bai, Shuai Wang, Yixuan Zhai, Shuheng Zhang, Chuzhong Li, Jiang Du and Yazhuo Zhang

    Citation: BMC Cancer 2020 20:988

    Content type: Research article

    Published on:

  37. In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-S...

    Authors: Yin-Zhe An, Eunae Cho, Junqi Ling and Xianglan Zhang

    Citation: BMC Cancer 2020 20:987

    Content type: Research article

    Published on:

  38. Idiopathic pulmonary fibrosis (IPF) is associated with an increased risk for lung cancer, but the underlying mechanisms driving malignant transformation remain largely unknown. This study aimed to identify dif...

    Authors: Dong Leng, Jiawen Yi, Maodong Xiang, Hongying Zhao and Yuhui Zhang

    Citation: BMC Cancer 2020 20:986

    Content type: Research article

    Published on:

  39. Esophageal cancer (EC) is considered as one of the deadliest malignancies with respect to incidence and mortality rate, and numerous risk factors may affect the prognosis of EC patients. For better understandi...

    Authors: Jingcheng Yang, Jun Shang, Qian Song, Zuyi Yang, Jianing Chen, Ying Yu and Leming Shi

    Citation: BMC Cancer 2020 20:985

    Content type: Technical advance

    Published on:

  40. Cytarabine (ara-C) is the major drug for the treatment of acute myeloid leukemia (AML), but cellular resistance to ara-C is a major obstacle to therapeutic success. The present study examined enhanced anti-apo...

    Authors: Rie Nishi, Hiroko Shigemi, Eiju Negoro, Miyuki Okura, Naoko Hosono and Takahiro Yamauchi

    Citation: BMC Cancer 2020 20:984

    Content type: Research article

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  41. Moroccan incidence of cancer is increasing with the lengthening of life expectancy. Data regarding elderly Moroccan cancer patients are lacking. In the context of our project aiming to develop an adapted versi...

    Authors: Mounia Amzerin, Mohamed Layachi, Aziz Bazine, Rachid Aassab, Samia Arifi, Zineb Benbrahim, Mohamed Reda Khmamouche, Mouna Kairouani, Hanan Raiss, Noura Majid, Saloua Ouaouch, Mohammed Ichou, Said Afqir, Nawfal Mellas, Mohamed Fetohi, Rachid Razine…

    Citation: BMC Cancer 2020 20:983

    Content type: Research article

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  42. 5–10% of patients are diagnosed with metastatic breast cancer (MBC) at the initial diagnosis. This study aimed to develop a nomogram to predict the overall survival (OS) of these patients.

    Authors: Wen Zhao, Lei Wu, Andi Zhao, Mi Zhang, Qi Tian, Yanwei Shen, Fan Wang, Biyuan Wang, Le Wang, Ling Chen, Xiaoai Zhao, Danfeng Dong, Lingxiao Zhang and Jin Yang

    Citation: BMC Cancer 2020 20:982

    Content type: Research article

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  43. Growing evidence indicates that the systemic inflammatory response plays an important role in cancer development and progression. Several inflammatory markers have been reported to be associated with clinical ...

    Authors: Shuxin Sun, Chaobin He, Jun Wang, Xin Huang, Jiali Wu and Shengping Li

    Citation: BMC Cancer 2020 20:981

    Content type: Research article

    Published on:

  44. Central nervous system germ cell tumors (CNS GCTs) are a heterogeneous group of brain tumors, which are more common in Asian countries. There have been different therapeutic strategies in treating germinoma an...

    Authors: Kyung Taek Hong, Da Hye Lee, Bo Kyung Kim, Hong Yul An, Jung Yoon Choi, Ji Hoon Phi, Jung-Eun Cheon, Hyoung Jin Kang, Seung-Ki Kim, Joo-Young Kim, Sung-Hye Park, Il Han Kim and Hee Young Shin

    Citation: BMC Cancer 2020 20:979

    Content type: Research article

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  45. Patients with high-risk prostate cancer are at increased risk of lymph node metastasis and are thought to benefit from whole pelvis radiotherapy (WPRT). There has been recent interest in the use of hypofractio...

    Authors: Lucas C. Mendez, Andrew J. Arifin, Glenn S. Bauman, Vikram M. Velker, Belal Ahmad, Michael Lock, Varagur M. Venkatesan, Tracy L. Sexton, George B. Rodrigues, Jeff Chen, Bryan Schaly, Andrew Warner and David P. D’Souza

    Citation: BMC Cancer 2020 20:978

    Content type: Study protocol

    Published on:

  46. Primary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS) are rare malignancies with frequent overlap in both the clinic and radiology. No comparative study of these tumors for the restric...

    Authors: Dongli Shi, Jun Sun, Liang Ma, Jing Chang and Hongjun Li

    Citation: BMC Cancer 2020 20:977

    Content type: Research article

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  47. lncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is sti...

    Authors: Jigao Feng, Yibin Ouyang, Dedong Xu, Qinglong He, Dayuan Liu, Xudong Fan, Pengxiang Xu and Yehe Mo

    Citation: BMC Cancer 2020 20:976

    Content type: Research article

    Published on:

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