Articles

Cardiovascular disease in women with breast cancer – a nationwide cohort study

There is increasing concern about cardiovascular disease (CVD) after breast cancer (BC). The aim of this study was to estimate the prevalence of different types of CVD in women diagnosed with BC compared to ca...

Authors: Marie Jakobsen, Christophe Kolodziejczyk, Morten Sall Jensen, Peter Bo Poulsen, Humma Khan, Thomas Kümler and Michael Andersson

Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory malignancy with poor prognosis. It is urgent to identify novel and valid biomarkers to predict the progress and prognosis of PDAC. The S10...

Authors: Hong-Bin Li, Jian-Li Wang, Xiao-Dong Jin, Lei Zhao, Hui-Li Ye, Yan-bei Kuang, Yong Ma, Xiang-Yan Jiang and Ze-Yuan Yu

Prediction of serosal invasion in gastric cancer: development and validation of multivariate models integrating preoperative clinicopathological features and radiographic findings based on late arterial phase CT images

To develop and validate multivariate models integrating endoscopic biopsy, tumor markers, and CT findings based on late arterial phase (LAP) to predict serosal invasion in gastric cancer (GC).

Authors: Song Liu, Mengying Xu, Xiangmei Qiao, Changfeng Ji, Lin Li and Zhengyang Zhou

Biomarker-based early detection of epithelial ovarian cancer based on a five-protein signature in patient’s plasma – a prospective trial

Trial on five plasma biomarkers (CA125, HE4, OPN, leptin, prolactin) and their possible role in differentiating benign from malignant ovarian tumors.

Authors: A. Hasenburg, D. Eichkorn, F. Vosshagen, E. Obermayr, A. Geroldinger, R. Zeillinger and M. Bossart

Physician-patient communication of costs and financial burden of cancer and its treatment: a systematic review of clinical guidelines

Optimising the care of individuals with cancer without imposing significant financial burden related to their anticancer treatment is becoming increasingly difficult. The American Society of Clinical Oncology ...

Authors: Anupriya Agarwal, Ann Livingstone, Deme J. Karikios, Martin R. Stockler, Philip J. Beale and Rachael L. Morton

A TP53 mutation model for the prediction of prognosis and therapeutic responses in head and neck squamous cell carcinoma

Tumor protein p53 (TP53) is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSC), and TP53 mutations are associated with inhibited immune signatures and poor prognosis. We established ...

Authors: Congyu Shi, Shan Liu, Xudong Tian, Xiaoyi Wang and Pan Gao

Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional study

Despite research efforts, the causative factors that contribute to esophageal squamous cell carcinoma (ESCC) in high-risk areas have not yet been understood. In this study, we, therefore, aimed to describe the...

Authors: Chen Niu, Yong Liu, Jialin Wang, Yuqin Liu, Shaokai Zhang, Yongzhen Zhang, Liwei Zhang, Deli Zhao, Fugang Liu, Lina Chao, Xinzheng Wang, Chunli Zhang, Guohui Song, Zhiyi Zhang, Youpeng Li, Zheng Yan…

Pyrotinib combined with thalidomide in advanced non-small-cell lung cancer patients harboring HER2 exon 20 insertions (PRIDE): protocol of an open-label, single-arm phase II trial

Standard therapy for human epidermal growth factor receptor 2 (HER2)-mutant non-small-cell lung cancer (NSCLC) is lacking. The clinical benefits with pan-HER inhibitors (afatinib, neratinib, and dacomitinib), ...

Authors: Xinghao Ai, Zhengbo Song, Hong Jian, Zhen Zhou, Zhiwei Chen, Yongfeng Yu, Ziming Li and Shun Lu

Prevention of radiotherapy induced enteropathy by probiotics (PREP): protocol for a double-blind randomized placebo-controlled trial

Radiation induced enteropathy is a common complication of radiotherapy for pelvic tumors and adversely affects patient quality of life. Probiotics are thought to restore bowel microflora to optimal levels and ...

Authors: Yeon Joo Kim, Jesang Yu, Sung Pyo Park, Seung Hae Lee and Young Seok Kim

Cervical cancer screening “see and treat approach”: real-life uptake after invitation and associated factors at health facilities in Gondar, Northwest Ethiopia

Although cervical cancer is a preventable disease, screening coverage in Ethiopia is far below the target. There is limited evidence on uptake among the general population in Ethiopia. Thus, this study was con...

Authors: Alemnew Destaw, Miresa Midaksa, Adamu Addissie, Eva Johanna Kantelhardt and Muluken Gizaw

A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer

Fluoropyrimidine plus platinum chemotherapy remains the standard first line treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD genotypes related to severe fluoropy...

Authors: Miguel Cordova-Delgado, María Loreto Bravo, Elisa Cumsille, Charlotte N. Hill, Matías Muñoz-Medel, Mauricio P. Pinto, Ignacio N. Retamal, María A. Lavanderos, Juan Francisco Miquel, Maria Rodriguez-Fernandez, Yuwei Liao, Zhiguang Li, Alejandro H. Corvalán, Ricardo Armisén, Marcelo Garrido, Luis A. Quiñones…

A CTLA-4 blocking strategy based on Nanoboby in dendritic cell-stimulated cytokine-induced killer cells enhances their anti-tumor effects

Cytokine-induced killer cells induced with tumor antigen-pulsed dendritic cells (DC-CIK) immunotherapy is a promising strategy for the treatment of malignant tumors. However, itsefficacy isrestricted by the im...

Authors: Wu Wang, Xi Wang, Wenli Yang, Kai Zhong, Na He, Xuexia Li, Yanyang Pang, Zi Lu, Aiqun Liu and Xiaoling Lu

Role of miR-182/PDCD4 axis in aggressive behavior of prostate cancer in the African Americans

Prostate cancer is one of the most commonly diagnosed cancers among men. African Americans (AA) are at an increased risk of developing prostate cancer compared to European Americans (EA). miRNAs play a critica...

Authors: Marisa Shiina, Yutaka Hashimoto, Priyanka Kulkarni, Pritha Dasgupta, Varahram Shahryari, Soichiro Yamamura, Yuichiro Tanaka and Rajvir Dahiya

Characteristics of 1270 Chinese sibling pairs with cancer

Previous research found that the cancer history of an individual’s sibling may be a better indicator than that of the parents. We aim to provide recommendations for opportunistic screening for individuals whos...

Authors: Ju Liu, Jian Yin, Yiwei Liu, Zhijian Xu and Kai Zhang

Co-expression and prognosis analyses of GLUT1–4 and RB1 in breast cancer

Current treatment methods for patients with triple-negative breast cancer (TNBC) are very limited, and the prognosis of TNBC is relatively poor. It has been reported that glucose transporter 1 (GLUT1) is overe...

Authors: Xiaodan Zhang, Xiaocong Pang, Zhuo Zhang, Qianxin Liu, Hanxu Zhang, Qian Xiang and Yimin Cui

Infrequent RAS mutation is not associated with specific histological phenotype in gliomas

Mutations in driver genes such as IDH and BRAF have been identified in gliomas. Meanwhile, dysregulations in the p53, RB1, and MAPK and/or PI3K pathways are involved in the molecular pathogenesis of glioblastoma....

Authors: Yasuhide Makino, Yoshiki Arakawa, Ema Yoshioka, Tomoko Shofuda, Sachiko Minamiguchi, Takeshi Kawauchi, Masahiro Tanji, Daisuke Kanematsu, Masahiro Nonaka, Yoshiko Okita, Yoshinori Kodama, Masayuki Mano, Takanori Hirose, Yohei Mineharu, Susumu Miyamoto and Yonehiro Kanemura

Correction to: TGFB-induced factor homeobox 1 (TGIF) expression in breast cancer

Authors: Christine Stürken, Volker Möbus, Karin Milde-Langosch, Sabine Schmatloch, Peter A. Fasching, Josef Rüschoff, Elmar Stickeler, Rolf-Peter Henke, Carsten Denkert, Lars Hanker, Christian Schem, Valentina Vladimirova, Thomas Karn, Valentina Nekljudova, Claus-Henning Köhne, Frederik Marmé…

Correction to: Outcomes based on plasma biomarkers in METEOR, a randomized phase 3 trial of cabozantinib vs everolimus in advanced renal cell carcinoma

Authors: Thomas Powles, Toni K. Choueiri, Robert J. Motzer, Eric Jonasch, Sumanta Pal, Nizar M. Tannir, Sabina Signoretti, Rajesh Kaldate, Christian Scheffold, Evelyn Wang, Dana T. Aftab, Bernard Escudier and Daniel J. George

eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1

Eukaryotic translation initiation factors (eIFs) are the key factors to synthesize translation initiation complexes during the synthesis of eukaryotic proteins. Besides, eIFs are especially important in regula...

Authors: Qi Li, Mulun Xiao, Yibo Shi, Jinhao Hu, Tianxiang Bi, Chaoliang Wang, Liang Yan and Xiaoyan Li

Prospective observational study on Pazopanib in patients treated for advanced or metastatic renal cell carcinoma in countries in Asia Pacific, North Africa, and Middle East regions: PARACHUTE study

Clinical effectiveness and safety data of pazopanib in patients with advanced or mRCC in real-world setting from Asia Pacific, North Africa, and Middle East countries are lacking.

Authors: Erman Mustafa, Biswas Bivas, Danchaivijitr Pongwut, Chen Lingwu, Yoke Fui Wong, Tarek Hashem, Chun Sen Lim, Bulent Karabulut, Hsiao-Jen Chung, Chandra Chikatapu, Sara Ingles, Khemaies Slimane and Ravindran Kanesvaran

Brachytherapy with Iodine-125 seeds for treatment of portal vein-branch tumor thrombus in patients with hepatocellular carcinoma

There is currently no widely-accepted consensus for the management of hepatocellular carcinoma with portal vein tumor thrombus. We evaluate the safety and efficacy of ultrasound-guided percutaneous brachythera...

Authors: Duo Hong, Yi Zhou, Xiaoting Wan, Hongying Su and Haibo Shao

Prevalence and associations of axillary web syndrome in Asian women after breast cancer surgery undergoing a community-based cancer rehabilitation program

Patients who have breast cancer surgery are at risk of axillary web syndrome (AWS), an under-recognized postsurgical complication which can result in shoulder morbidity and functional impairment. Emerging stud...

Authors: Matthew Rong Jie Tay, Chin Jung Wong and Hui Zhen Aw

Influence of migrant background on patient preference and expectations in breast and gynecological malignancies (NOGGO-expression V study): results of a prospective multicentre study in 606 patients in Germany

An effective cross-cultural doctor-patient communication is vital for health literacy and patient compliance. Building a good relationship with medical staff is also relevant for the treatment decision-making ...

Authors: D. Dimitrova, B. Naghavi, R. Richter, S. Nasser, R. Chekerov, E. I. Braicu, M. David, J. Blohmer, G. Inci, U. Torsten, G. Oskay-Özcelik, I. Blau, N. Fersis, A. Holzgreve, E. Keil, M. Keller…

Estrogen markedly reduces circulating low-density neutrophils and enhances pro-tumoral gene expression in neutrophil of tumour-bearing mice

Neutrophils are important for immune surveillance of tumour cells. Neutrophils may also be epigenetically programmed in the tumour microenvironment to promote tumour progression. In addition to the commonly kn...

Authors: Chew Leng Lim and Valerie C.-L. Lin

Postoperative morbidity and quality of life between totally laparoscopic total gastrectomy and laparoscopy-assisted total gastrectomy: a propensity-score matched analysis

This study aimed to evaluate the surgical outcome and quality of life (QoL) of totally laparoscopic total gastrectomy (TLTG) compared with laparoscopy-assisted total gastrectomy (LATG) in patients with clinica...

Authors: Shin-Hoo Park, Yun-Suhk Suh, Tae-Han Kim, Yoon-Hee Choi, Jong-Ho Choi, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee and Han-Kwang Yang

¹⁸F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD)

Graft versus host disease (GvHD) is a frequent complication of allogeneic stem cell transplantation (alloSCT), significantly increasing mortality. Previous imaging studies focused on the assessment of intestin...

Authors: Wolfgang Roll, Philipp Schindler, Max Masthoff, Rebecca Strotmann, Jörn Albring, Christian Reicherts, Matthias Weckesser, Benjamin Noto, Matthias Stelljes, Michael Schäfers and Georg Evers

Adjuvant immunotherapy recommendations for stage III melanoma: physician and nurse interviews

Adjuvant immunotherapy is revolutionising care for patients with resected stage III and IV melanoma. However, immunotherapy may be associated with toxicity, making treatment decisions complicated. This study a...

Authors: Ann Livingstone, Kathy Dempsey, Martin R. Stockler, Kirsten Howard, Georgina V. Long, Matteo S. Carlino, Alexander M. Menzies and Rachael L. Morton

The role of Magnetic Resonance Images (MRIs) in coping for patients with brain tumours and their parents: a qualitative study

When children and young people (CYP) are diagnosed with a brain tumour, Magnetic Resonance Imaging (MRI) is key to the clinical management of this condition. This can produce hundreds, and often thousands, of ...

Authors: Natalie Tyldesley-Marshall, Sheila Greenfield, Susan J. Neilson, Martin English, Jenny Adamski and Andrew Peet

Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway

UEV1A encodes a ubiquitin-E2 variant closely associated with tumorigenesis and metastasis, but its underlying mechanism in promoting metastasis remains to be investigated.

Authors: Tong Niu, Zhaojia Wu and Wei Xiao

Application of CD54 in diagnosing bone marrow involvement by using flow cytometry in patients with diffuse large B-cell lymphoma

Flow cytometry plays a key role in detecting bone marrow (BM) involvement in patients with diffuse large B-cell lymphoma (DLBCL). To improve its detection sensitivity, we need to explore novel markers. In this...

Authors: Wei Wang, Yan Li, Xavier Rivera Rivera, Linjun Zhao, Di Mei, Wenqing Hu and Bin Jiang

Study protocol for OptimalTTF-2: enhancing Tumor Treating Fields with skull remodeling surgery for first recurrence glioblastoma: a phase 2, multi-center, randomized, prospective, interventional trial

OptimalTTF-2 is a randomized, comparative, multi-center, investigator-initiated, interventional study aiming to test skull remodeling surgery in combination with Tumor Treating Fields therapy (TTFields) and be...

Authors: N. Mikic, F. R. Poulsen, K. B. Kristoffersen, R. J. Laursen, T. L. Guldberg, J. Skjøth-Rasmussen, E. T. Wong, S. Møller, R. H. Dahlrot, J. C. H. Sørensen and A. R. Korshøj

Incidence and survival analyses for occult lung cancer between 2004 and 2015: a population-based study

This study aimed to investigate the incidence and long-term survival outcomes of occult lung cancer between 2004 and 2015.

Authors: Lei-Lei Wu, Chong-Wu Li, Wei-Kang Lin, Li-Hong Qiu and Dong Xie

Evaluating the effect of Neoadjuvant chemotherapy for esophageal Cancer using the RECIST system with shorter-axis measurements: a retrospective multicenter study

Evaluating the effect on primary lesions is important in determining treatment strategies for esophageal cancer. The Response Evaluation Criteria in Solid Tumors system, which employs the longest diameter for ...

Authors: Yusuke Taniyama, Kentaro Murakami, Naoya Yoshida, Kozue Takahashi, Hisahiro Matsubara, Hideo Baba and Takashi Kamei

Distinct tumour antigen-specific T-cell immune response profiles at different hepatocellular carcinoma stages

Cancer-testis antigens (CTAs) and tumour-associated antigens (TAAs) are frequently expressed in hepatocellular carcinoma (HCC); however, the role of tumour-antigen-specific T cell immunity in HCC progression i...

Authors: Chaoran Zang, Yan Zhao, Ling Qin, Guihai Liu, Jianping Sun, Kang Li, Yanan Zhao, Shoupeng Sheng, Honghai Zhang, Ning He, Peng Zhao, Qi Wang, Xi Li, Yanchun Peng, Tao Dong and Yonghong Zhang

Dysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes

Hepatocellular carcinoma (HCC) is a major cause of cancer-related death. Paired related homeobox 1 (PRRX1) is a transcription factor that regulates cell growth and differentiation, but its importance in HCC is...

Authors: Weronika Piorońska, Zeribe Chike Nwosu, Mei Han, Michael Büttner, Matthias Philip Ebert, Steven Dooley and Christoph Meyer

Weight changes according to treatment in a diverse cohort of breast cancer patients

Weight changes are common among breast cancer patients. The majority of studies to date have focused on weight gain after a breast cancer diagnosis and its implications on health in survivors. Fewer studies ha...

Authors: Jami Fukui, Kami White, Timothy B. Frankland, Caryn Oshiro and Lynne Wilkens

LINC00852 promotes the proliferation and invasion of ovarian cancer cells by competitively binding with miR-140-3p to regulate AGTR1 expression

Dysregulation of long non-coding RNAs (lncRNAs) has been identified in ovarian cancer. However, the expression and biological functions of LINC00852 in ovarian cancer are not understood.

Authors: Zhi-wei Qiao, Ying Jiang, Ling Wang, Lei Wang, Jing Jiang, Jing-ru Zhang and Peng Mu

Exosomal ERp44 derived from ER-stressed cells strengthens cisplatin resistance of nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in head and neck. Platinum-based chemotherapy is an important treatment for NPC. However, the molecular mechanism of resistance to platinum...

Authors: Tian Xia, Hui Tian, Kaiwen Zhang, Siyu Zhang, Wenhui Chen, Si Shi and Yiwen You

CML derived exosomes promote tumor favorable functional performance in T cells

Leukemic cells facilitate the creation of the tumor-favorable microenvironment in the bone marrow niche using their secreted factors. There are not comprehensive details about immunosuppressive properties of c...

Authors: Nazli Jafarzadeh, Mohammad Ali Gholampour, Mohammad-Reza Alivand, Saeideh Kavousi, Laleh Arzi, Fariba Rad, Majid Sadeghizadeh and Majid Pornour

Transcriptional analysis of the expression, prognostic value and immune infiltration activities of the COMMD protein family in hepatocellular carcinoma

The copper metabolism MURR1 domain (COMMD) protein family involved in tumor development and progression in several types of human cancer, but little is known about the function of COMMD proteins in hepatocellu...

Authors: Xiaobo Wang, Shujiao He, Xin Zheng, Shanzhou Huang, Honghui Chen, Huadi Chen, Weixin Luo, Zhiyong Guo, Xiaoshun He and Qiang Zhao

Analysis of the correlation between high iodized salt intake and the risk of thyroid nodules: a large retrospective study

Currently, whether daily excess iodized salt intake increases the risk of thyroid nodules and even thyroid cancer remains controversial. Our research group aimed to provide a theoretical basis for the clinical...

Authors: Yaohui Wang, Jiangang Wang, Zhihen Chen, Min Ma, Changwei Lin, Qingnan He and Mingzhu Ye

Construction of a survival prediction model for high-and low -grade UTUC after tumor resection based on “SEER database”: a multicenter study

There are differences in survival between high-and low-grade Upper Tract Urothelial Carcinoma (UTUC). Our study aimed to develop a nomogram to predict overall survival (OS) of patients with high- and low-grade...

Authors: Mengmeng Wang, Xin Ren, Ge Wang, Xiaomin Sun, Shifeng Tang, Baogang Zhang, Xiaoming Xing, Wenfeng Zhang, Guojun Gao, Jing Du, Shukun Zhang, Lijuan Liu, Xia Zheng, Zhenkun Zhang and Changgang Sun

Race disparities in mortality by breast cancer from 2000 to 2017 in São Paulo, Brazil: a population-based retrospective study

In Brazil, inequalities in access may interfere with cancer care. This study aimed to evaluate the influence of race on breast cancer mortality in the state of São Paulo, from 2000 to 2017, contextualizing wit...

Authors: Ana Cláudia Marcelino, Bruno Gozzi, Cássio Cardoso-Filho, Helymar Machado, Luiz Carlos Zeferino and Diama Bhadra Vale

Association study of relationships of polymorphisms in the miR-21, miR-26b, miR-221/222 and miR-126 genes with cervical intraepithelial neoplasia and cervical cancer

miR-21, miR-26b, miR-221/222 and miR-126 play crucial roles in cervical cancer development. Studies have shown that polymorphisms in miRNA genes can affect miRNA expression, which might be associated with cancer ...

Authors: Jia Yang, Zhiling Yan, Yingying Wang, Jinmei Xu, Rui Li, Chuanyin Li, Shuyuan Liu, Li Shi and Yufeng Yao

The role of education on Cancer amenable mortality among non-Hispanic blacks & non-Hispanic whites in the United States (1989–2018)

Cancer mortality in the U.S. has fallen in recent decades; however, individuals with lower levels of education experienced a smaller decline than more highly educated individuals. This analysis aimed to measur...

Authors: Alberto Barcelo, Linda Duffett-Leger, Maria Pastor-Valero, Juliana Pereira, Fernando A. B. Colugnati and Edward Trapido

Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis

Esophageal cancer is a common malignant tumor and its 5-year survival rate is much lower than 30% due to its invasiveness and pronounced metastasis ability, as well as the difficulty in early diagnosis. This s...

Authors: Rong Li, Xing-Feng Pang, Zhi-Guang Huang, Li-Hua Yang, Zhi-Gang Peng, Jie Ma and Rong-Quan He

Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis

Pathological grading of non-invasive urothelial carcinoma has a direct impact upon management. This study evaluates the reproducibility of grading these tumours on glass slides and digital pathology.

Authors: Richard Colling, Hayleigh Colling, Lisa Browning and Clare Verrill

Comparison of monoclonal antibodies targeting CD38, SLAMF7 and PD-1/PD-L1 in combination with Bortezomib/Immunomodulators plus dexamethasone/prednisone for the treatment of multiple myeloma: an indirect-comparison Meta-analysis of randomised controlled trials

Many clinical trials have assessed the effect and safety of monoclonal antibodies (MAbs) in combination with proteasome inhibitors or immunomodulators plus dexamethasone/prednisone for the treatment of multipl...

Authors: Wu Ye, Xia Wu, Xiaoyan Liu, Xue Zheng, Jili Deng and Yuping Gong

Quality of life analyses in patients with multiple myeloma: results from the Selinexor (KPT-330) Treatment of Refractory Myeloma (STORM) phase 2b study

Selinexor is an oral, selective nuclear export inhibitor. STORM was a phase 2b, single-arm, open-label, multicenter trial of selinexor with low dose dexamethasone in patients with penta-exposed relapsed/refrac...

Authors: Gabriel Tremblay, Patrick Daniele, Janis Breeze, Lingling Li, Jatin Shah, Sharon Shacham, Michael Kauffman, Monika Engelhardt, Ajaj Chari, Ajay Nooka, Dan Vogl, Maria Gavriatopoulou, Meletios-Athanasios Dimopoulos, Paul Richardson, Noa Biran, David Siegel…

Up-regulation expression and prognostic significance of Syntaxin4 in kidney renal clear cell carcinoma

Syntaxin4 (STX4) gene encodes the protein STX4, a member of soluble N-ethylmaleimide-sensitive factor attachment protein receptors protein, playing a vital role in cell invadopodium formation and invasion, whi...

Authors: Lishan He, Huiming Jiang, Zhenqiang Lai, Zhixiong Zhong and Zhanqin Huang