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  1. There is increasing concern about cardiovascular disease (CVD) after breast cancer (BC). The aim of this study was to estimate the prevalence of different types of CVD in women diagnosed with BC compared to ca...

    Authors: Marie Jakobsen, Christophe Kolodziejczyk, Morten Sall Jensen, Peter Bo Poulsen, Humma Khan, Thomas Kümler and Michael Andersson

    Citation: BMC Cancer 2021 21:1040

    Content type: Research article

    Published on:

  2. Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory malignancy with poor prognosis. It is urgent to identify novel and valid biomarkers to predict the progress and prognosis of PDAC. The S10...

    Authors: Hong-Bin Li, Jian-Li Wang, Xiao-Dong Jin, Lei Zhao, Hui-Li Ye, Yan-bei Kuang, Yong Ma, Xiang-Yan Jiang and Ze-Yuan Yu

    Citation: BMC Cancer 2021 21:1039

    Content type: Research

    Published on:

  3. To develop and validate multivariate models integrating endoscopic biopsy, tumor markers, and CT findings based on late arterial phase (LAP) to predict serosal invasion in gastric cancer (GC).

    Authors: Song Liu, Mengying Xu, Xiangmei Qiao, Changfeng Ji, Lin Li and Zhengyang Zhou

    Citation: BMC Cancer 2021 21:1038

    Content type: Research

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  4. Trial on five plasma biomarkers (CA125, HE4, OPN, leptin, prolactin) and their possible role in differentiating benign from malignant ovarian tumors.

    Authors: A. Hasenburg, D. Eichkorn, F. Vosshagen, E. Obermayr, A. Geroldinger, R. Zeillinger and M. Bossart

    Citation: BMC Cancer 2021 21:1037

    Content type: Research article

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  5. Optimising the care of individuals with cancer without imposing significant financial burden related to their anticancer treatment is becoming increasingly difficult. The American Society of Clinical Oncology ...

    Authors: Anupriya Agarwal, Ann Livingstone, Deme J. Karikios, Martin R. Stockler, Philip J. Beale and Rachael L. Morton

    Citation: BMC Cancer 2021 21:1036

    Content type: Research article

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  6. Tumor protein p53 (TP53) is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSC), and TP53 mutations are associated with inhibited immune signatures and poor prognosis. We established ...

    Authors: Congyu Shi, Shan Liu, Xudong Tian, Xiaoyi Wang and Pan Gao

    Citation: BMC Cancer 2021 21:1035

    Content type: Research

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  7. Despite research efforts, the causative factors that contribute to esophageal squamous cell carcinoma (ESCC) in high-risk areas have not yet been understood. In this study, we, therefore, aimed to describe the...

    Authors: Chen Niu, Yong Liu, Jialin Wang, Yuqin Liu, Shaokai Zhang, Yongzhen Zhang, Liwei Zhang, Deli Zhao, Fugang Liu, Lina Chao, Xinzheng Wang, Chunli Zhang, Guohui Song, Zhiyi Zhang, Youpeng Li, Zheng Yan…

    Citation: BMC Cancer 2021 21:1034

    Content type: Research

    Published on:

  8. Standard therapy for human epidermal growth factor receptor 2 (HER2)-mutant non-small-cell lung cancer (NSCLC) is lacking. The clinical benefits with pan-HER inhibitors (afatinib, neratinib, and dacomitinib), ...

    Authors: Xinghao Ai, Zhengbo Song, Hong Jian, Zhen Zhou, Zhiwei Chen, Yongfeng Yu, Ziming Li and Shun Lu

    Citation: BMC Cancer 2021 21:1033

    Content type: Study protocol

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  9. Radiation induced enteropathy is a common complication of radiotherapy for pelvic tumors and adversely affects patient quality of life. Probiotics are thought to restore bowel microflora to optimal levels and ...

    Authors: Yeon Joo Kim, Jesang Yu, Sung Pyo Park, Seung Hae Lee and Young Seok Kim

    Citation: BMC Cancer 2021 21:1032

    Content type: Study protocol

    Published on:

  10. Although cervical cancer is a preventable disease, screening coverage in Ethiopia is far below the target. There is limited evidence on uptake among the general population in Ethiopia. Thus, this study was con...

    Authors: Alemnew Destaw, Miresa Midaksa, Adamu Addissie, Eva Johanna Kantelhardt and Muluken Gizaw

    Citation: BMC Cancer 2021 21:1031

    Content type: Research

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  11. Fluoropyrimidine plus platinum chemotherapy remains the standard first line treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD genotypes related to severe fluoropy...

    Authors: Miguel Cordova-Delgado, María Loreto Bravo, Elisa Cumsille, Charlotte N. Hill, Matías Muñoz-Medel, Mauricio P. Pinto, Ignacio N. Retamal, María A. Lavanderos, Juan Francisco Miquel, Maria Rodriguez-Fernandez, Yuwei Liao, Zhiguang Li, Alejandro H. Corvalán, Ricardo Armisén, Marcelo Garrido, Luis A. Quiñones…

    Citation: BMC Cancer 2021 21:1030

    Content type: Research

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  12. Cytokine-induced killer cells induced with tumor antigen-pulsed dendritic cells (DC-CIK) immunotherapy is a promising strategy for the treatment of malignant tumors. However, itsefficacy isrestricted by the im...

    Authors: Wu Wang, Xi Wang, Wenli Yang, Kai Zhong, Na He, Xuexia Li, Yanyang Pang, Zi Lu, Aiqun Liu and Xiaoling Lu

    Citation: BMC Cancer 2021 21:1029

    Content type: Research

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  13. Prostate cancer is one of the most commonly diagnosed cancers among men. African Americans (AA) are at an increased risk of developing prostate cancer compared to European Americans (EA). miRNAs play a critica...

    Authors: Marisa Shiina, Yutaka Hashimoto, Priyanka Kulkarni, Pritha Dasgupta, Varahram Shahryari, Soichiro Yamamura, Yuichiro Tanaka and Rajvir Dahiya

    Citation: BMC Cancer 2021 21:1028

    Content type: Research

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  14. Previous research found that the cancer history of an individual’s sibling may be a better indicator than that of the parents. We aim to provide recommendations for opportunistic screening for individuals whos...

    Authors: Ju Liu, Jian Yin, Yiwei Liu, Zhijian Xu and Kai Zhang

    Citation: BMC Cancer 2021 21:1027

    Content type: Research

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  15. Current treatment methods for patients with triple-negative breast cancer (TNBC) are very limited, and the prognosis of TNBC is relatively poor. It has been reported that glucose transporter 1 (GLUT1) is overe...

    Authors: Xiaodan Zhang, Xiaocong Pang, Zhuo Zhang, Qianxin Liu, Hanxu Zhang, Qian Xiang and Yimin Cui

    Citation: BMC Cancer 2021 21:1026

    Content type: Research

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  16. Mutations in driver genes such as IDH and BRAF have been identified in gliomas. Meanwhile, dysregulations in the p53, RB1, and MAPK and/or PI3K pathways are involved in the molecular pathogenesis of glioblastoma....

    Authors: Yasuhide Makino, Yoshiki Arakawa, Ema Yoshioka, Tomoko Shofuda, Sachiko Minamiguchi, Takeshi Kawauchi, Masahiro Tanji, Daisuke Kanematsu, Masahiro Nonaka, Yoshiko Okita, Yoshinori Kodama, Masayuki Mano, Takanori Hirose, Yohei Mineharu, Susumu Miyamoto and Yonehiro Kanemura

    Citation: BMC Cancer 2021 21:1025

    Content type: Research

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  17. Authors: Christine Stürken, Volker Möbus, Karin Milde-Langosch, Sabine Schmatloch, Peter A. Fasching, Josef Rüschoff, Elmar Stickeler, Rolf-Peter Henke, Carsten Denkert, Lars Hanker, Christian Schem, Valentina Vladimirova, Thomas Karn, Valentina Nekljudova, Claus-Henning Köhne, Frederik Marmé…

    Citation: BMC Cancer 2021 21:1024

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2021 21:920

  18. Authors: Thomas Powles, Toni K. Choueiri, Robert J. Motzer, Eric Jonasch, Sumanta Pal, Nizar M. Tannir, Sabina Signoretti, Rajesh Kaldate, Christian Scheffold, Evelyn Wang, Dana T. Aftab, Bernard Escudier and Daniel J. George

    Citation: BMC Cancer 2021 21:1023

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2021 21:904

  19. Eukaryotic translation initiation factors (eIFs) are the key factors to synthesize translation initiation complexes during the synthesis of eukaryotic proteins. Besides, eIFs are especially important in regula...

    Authors: Qi Li, Mulun Xiao, Yibo Shi, Jinhao Hu, Tianxiang Bi, Chaoliang Wang, Liang Yan and Xiaoyan Li

    Citation: BMC Cancer 2021 21:1022

    Content type: Research

    Published on:

  20. Clinical effectiveness and safety data of pazopanib in patients with advanced or mRCC in real-world setting from Asia Pacific, North Africa, and Middle East countries are lacking.

    Authors: Erman Mustafa, Biswas Bivas, Danchaivijitr Pongwut, Chen Lingwu, Yoke Fui Wong, Tarek Hashem, Chun Sen Lim, Bulent Karabulut, Hsiao-Jen Chung, Chandra Chikatapu, Sara Ingles, Khemaies Slimane and Ravindran Kanesvaran

    Citation: BMC Cancer 2021 21:1021

    Content type: Research

    Published on:

  21. There is currently no widely-accepted consensus for the management of hepatocellular carcinoma with portal vein tumor thrombus. We evaluate the safety and efficacy of ultrasound-guided percutaneous brachythera...

    Authors: Duo Hong, Yi Zhou, Xiaoting Wan, Hongying Su and Haibo Shao

    Citation: BMC Cancer 2021 21:1020

    Content type: Research article

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  22. Patients who have breast cancer surgery are at risk of axillary web syndrome (AWS), an under-recognized postsurgical complication which can result in shoulder morbidity and functional impairment. Emerging stud...

    Authors: Matthew Rong Jie Tay, Chin Jung Wong and Hui Zhen Aw

    Citation: BMC Cancer 2021 21:1019

    Content type: Research

    Published on:

  23. An effective cross-cultural doctor-patient communication is vital for health literacy and patient compliance. Building a good relationship with medical staff is also relevant for the treatment decision-making ...

    Authors: D. Dimitrova, B. Naghavi, R. Richter, S. Nasser, R. Chekerov, E. I. Braicu, M. David, J. Blohmer, G. Inci, U. Torsten, G. Oskay-Özcelik, I. Blau, N. Fersis, A. Holzgreve, E. Keil, M. Keller…

    Citation: BMC Cancer 2021 21:1018

    Content type: Research

    Published on:

  24. Neutrophils are important for immune surveillance of tumour cells. Neutrophils may also be epigenetically programmed in the tumour microenvironment to promote tumour progression. In addition to the commonly kn...

    Authors: Chew Leng Lim and Valerie C.-L. Lin

    Citation: BMC Cancer 2021 21:1017

    Content type: Research

    Published on:

  25. This study aimed to evaluate the surgical outcome and quality of life (QoL) of totally laparoscopic total gastrectomy (TLTG) compared with laparoscopy-assisted total gastrectomy (LATG) in patients with clinica...

    Authors: Shin-Hoo Park, Yun-Suhk Suh, Tae-Han Kim, Yoon-Hee Choi, Jong-Ho Choi, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee and Han-Kwang Yang

    Citation: BMC Cancer 2021 21:1016

    Content type: Research

    Published on:

  26. Graft versus host disease (GvHD) is a frequent complication of allogeneic stem cell transplantation (alloSCT), significantly increasing mortality. Previous imaging studies focused on the assessment of intestin...

    Authors: Wolfgang Roll, Philipp Schindler, Max Masthoff, Rebecca Strotmann, Jörn Albring, Christian Reicherts, Matthias Weckesser, Benjamin Noto, Matthias Stelljes, Michael Schäfers and Georg Evers

    Citation: BMC Cancer 2021 21:1015

    Content type: Research

    Published on:

  27. Adjuvant immunotherapy is revolutionising care for patients with resected stage III and IV melanoma. However, immunotherapy may be associated with toxicity, making treatment decisions complicated. This study a...

    Authors: Ann Livingstone, Kathy Dempsey, Martin R. Stockler, Kirsten Howard, Georgina V. Long, Matteo S. Carlino, Alexander M. Menzies and Rachael L. Morton

    Citation: BMC Cancer 2021 21:1014

    Content type: Research

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  28. When children and young people (CYP) are diagnosed with a brain tumour, Magnetic Resonance Imaging (MRI) is key to the clinical management of this condition. This can produce hundreds, and often thousands, of ...

    Authors: Natalie Tyldesley-Marshall, Sheila Greenfield, Susan J. Neilson, Martin English, Jenny Adamski and Andrew Peet

    Citation: BMC Cancer 2021 21:1013

    Content type: Research

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  29. Flow cytometry plays a key role in detecting bone marrow (BM) involvement in patients with diffuse large B-cell lymphoma (DLBCL). To improve its detection sensitivity, we need to explore novel markers. In this...

    Authors: Wei Wang, Yan Li, Xavier Rivera Rivera, Linjun Zhao, Di Mei, Wenqing Hu and Bin Jiang

    Citation: BMC Cancer 2021 21:1011

    Content type: Research

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  30. OptimalTTF-2 is a randomized, comparative, multi-center, investigator-initiated, interventional study aiming to test skull remodeling surgery in combination with Tumor Treating Fields therapy (TTFields) and be...

    Authors: N. Mikic, F. R. Poulsen, K. B. Kristoffersen, R. J. Laursen, T. L. Guldberg, J. Skjøth-Rasmussen, E. T. Wong, S. Møller, R. H. Dahlrot, J. C. H. Sørensen and A. R. Korshøj

    Citation: BMC Cancer 2021 21:1010

    Content type: Study protocol

    Published on:

  31. Evaluating the effect on primary lesions is important in determining treatment strategies for esophageal cancer. The Response Evaluation Criteria in Solid Tumors system, which employs the longest diameter for ...

    Authors: Yusuke Taniyama, Kentaro Murakami, Naoya Yoshida, Kozue Takahashi, Hisahiro Matsubara, Hideo Baba and Takashi Kamei

    Citation: BMC Cancer 2021 21:1008

    Content type: Research

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  32. Cancer-testis antigens (CTAs) and tumour-associated antigens (TAAs) are frequently expressed in hepatocellular carcinoma (HCC); however, the role of tumour-antigen-specific T cell immunity in HCC progression i...

    Authors: Chaoran Zang, Yan Zhao, Ling Qin, Guihai Liu, Jianping Sun, Kang Li, Yanan Zhao, Shoupeng Sheng, Honghai Zhang, Ning He, Peng Zhao, Qi Wang, Xi Li, Yanchun Peng, Tao Dong and Yonghong Zhang

    Citation: BMC Cancer 2021 21:1007

    Content type: Research

    Published on:

  33. Hepatocellular carcinoma (HCC) is a major cause of cancer-related death. Paired related homeobox 1 (PRRX1) is a transcription factor that regulates cell growth and differentiation, but its importance in HCC is...

    Authors: Weronika Piorońska, Zeribe Chike Nwosu, Mei Han, Michael Büttner, Matthias Philip Ebert, Steven Dooley and Christoph Meyer

    Citation: BMC Cancer 2021 21:1006

    Content type: Research

    Published on:

  34. Weight changes are common among breast cancer patients. The majority of studies to date have focused on weight gain after a breast cancer diagnosis and its implications on health in survivors. Fewer studies ha...

    Authors: Jami Fukui, Kami White, Timothy B. Frankland, Caryn Oshiro and Lynne Wilkens

    Citation: BMC Cancer 2021 21:1005

    Content type: Research article

    Published on:

  35. Dysregulation of long non-coding RNAs (lncRNAs) has been identified in ovarian cancer. However, the expression and biological functions of LINC00852 in ovarian cancer are not understood.

    Authors: Zhi-wei Qiao, Ying Jiang, Ling Wang, Lei Wang, Jing Jiang, Jing-ru Zhang and Peng Mu

    Citation: BMC Cancer 2021 21:1004

    Content type: Research article

    Published on:

  36. Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in head and neck. Platinum-based chemotherapy is an important treatment for NPC. However, the molecular mechanism of resistance to platinum...

    Authors: Tian Xia, Hui Tian, Kaiwen Zhang, Siyu Zhang, Wenhui Chen, Si Shi and Yiwen You

    Citation: BMC Cancer 2021 21:1003

    Content type: Research article

    Published on:

  37. Leukemic cells facilitate the creation of the tumor-favorable microenvironment in the bone marrow niche using their secreted factors. There are not comprehensive details about immunosuppressive properties of c...

    Authors: Nazli Jafarzadeh, Mohammad Ali Gholampour, Mohammad-Reza Alivand, Saeideh Kavousi, Laleh Arzi, Fariba Rad, Majid Sadeghizadeh and Majid Pornour

    Citation: BMC Cancer 2021 21:1002

    Content type: Research

    Published on:

  38. The copper metabolism MURR1 domain (COMMD) protein family involved in tumor development and progression in several types of human cancer, but little is known about the function of COMMD proteins in hepatocellu...

    Authors: Xiaobo Wang, Shujiao He, Xin Zheng, Shanzhou Huang, Honghui Chen, Huadi Chen, Weixin Luo, Zhiyong Guo, Xiaoshun He and Qiang Zhao

    Citation: BMC Cancer 2021 21:1001

    Content type: Research article

    Published on:

  39. Currently, whether daily excess iodized salt intake increases the risk of thyroid nodules and even thyroid cancer remains controversial. Our research group aimed to provide a theoretical basis for the clinical...

    Authors: Yaohui Wang, Jiangang Wang, Zhihen Chen, Min Ma, Changwei Lin, Qingnan He and Mingzhu Ye

    Citation: BMC Cancer 2021 21:1000

    Content type: Research

    Published on:

  40. There are differences in survival between high-and low-grade Upper Tract Urothelial Carcinoma (UTUC). Our study aimed to develop a nomogram to predict overall survival (OS) of patients with high- and low-grade...

    Authors: Mengmeng Wang, Xin Ren, Ge Wang, Xiaomin Sun, Shifeng Tang, Baogang Zhang, Xiaoming Xing, Wenfeng Zhang, Guojun Gao, Jing Du, Shukun Zhang, Lijuan Liu, Xia Zheng, Zhenkun Zhang and Changgang Sun

    Citation: BMC Cancer 2021 21:999

    Content type: Research

    Published on:

  41. In Brazil, inequalities in access may interfere with cancer care. This study aimed to evaluate the influence of race on breast cancer mortality in the state of São Paulo, from 2000 to 2017, contextualizing wit...

    Authors: Ana Cláudia Marcelino, Bruno Gozzi, Cássio Cardoso-Filho, Helymar Machado, Luiz Carlos Zeferino and Diama Bhadra Vale

    Citation: BMC Cancer 2021 21:998

    Content type: Research

    Published on:

  42. miR-21, miR-26b, miR-221/222 and miR-126 play crucial roles in cervical cancer development. Studies have shown that polymorphisms in miRNA genes can affect miRNA expression, which might be associated with cancer ...

    Authors: Jia Yang, Zhiling Yan, Yingying Wang, Jinmei Xu, Rui Li, Chuanyin Li, Shuyuan Liu, Li Shi and Yufeng Yao

    Citation: BMC Cancer 2021 21:997

    Content type: Research

    Published on:

  43. Cancer mortality in the U.S. has fallen in recent decades; however, individuals with lower levels of education experienced a smaller decline than more highly educated individuals. This analysis aimed to measur...

    Authors: Alberto Barcelo, Linda Duffett-Leger, Maria Pastor-Valero, Juliana Pereira, Fernando A. B. Colugnati and Edward Trapido

    Citation: BMC Cancer 2021 21:907

    Content type: Research

    Published on:

  44. Esophageal cancer is a common malignant tumor and its 5-year survival rate is much lower than 30% due to its invasiveness and pronounced metastasis ability, as well as the difficulty in early diagnosis. This s...

    Authors: Rong Li, Xing-Feng Pang, Zhi-Guang Huang, Li-Hua Yang, Zhi-Gang Peng, Jie Ma and Rong-Quan He

    Citation: BMC Cancer 2021 21:996

    Content type: Research

    Published on:

  45. Many clinical trials have assessed the effect and safety of monoclonal antibodies (MAbs) in combination with proteasome inhibitors or immunomodulators plus dexamethasone/prednisone for the treatment of multipl...

    Authors: Wu Ye, Xia Wu, Xiaoyan Liu, Xue Zheng, Jili Deng and Yuping Gong

    Citation: BMC Cancer 2021 21:994

    Content type: Research article

    Published on:

  46. Selinexor is an oral, selective nuclear export inhibitor. STORM was a phase 2b, single-arm, open-label, multicenter trial of selinexor with low dose dexamethasone in patients with penta-exposed relapsed/refrac...

    Authors: Gabriel Tremblay, Patrick Daniele, Janis Breeze, Lingling Li, Jatin Shah, Sharon Shacham, Michael Kauffman, Monika Engelhardt, Ajaj Chari, Ajay Nooka, Dan Vogl, Maria Gavriatopoulou, Meletios-Athanasios Dimopoulos, Paul Richardson, Noa Biran, David Siegel…

    Citation: BMC Cancer 2021 21:993

    Content type: Research article

    Published on:

  47. Syntaxin4 (STX4) gene encodes the protein STX4, a member of soluble N-ethylmaleimide-sensitive factor attachment protein receptors protein, playing a vital role in cell invadopodium formation and invasion, whi...

    Authors: Lishan He, Huiming Jiang, Zhenqiang Lai, Zhixiong Zhong and Zhanqin Huang

    Citation: BMC Cancer 2021 21:992

    Content type: Research

    Published on:

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