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  1. Symptom Screening in Pediatrics Tool (SSPedi) was developed for symptom screening by children 8-18 years. Objectives were to evaluate the reliability and validity of proxy-SSPedi and self-report mini-SSPedi fo...

    Authors: Deborah Tomlinson, L. Lee Dupuis, Donna L. Johnston, Susan Kuczynski, Serina Patel, Tal Schechter, Emily Vettese, Mark Mairs, George A. Tomlinson and Lillian Sung
    Citation: BMC Cancer 2022 22:730
    Content type: Research Published on:

  2. Glioblastoma is one of the most common brain cancers in adults, and is characterized by recurrence and little curative effect. An effective treatment for glioblastoma patients remains elusive worldwide. 7-meth...

    Authors: Xinrui Wu, Chuanyu Li, Zhisu Wang, Yundi Zhang, Shifan Liu, Siqi Chen, Shuai Chen, Wangrui Liu and Xiaoman Liu
    Citation: BMC Cancer 2022 22:729
    Content type: Research Published on:

  3. Osteosarcoma (OS) is the most common primary malignant bone tumors in children and adolescents. Large numbers of studies have focused on the long non-coding RNA (lncRNA) that plays essential roles in the progr...

    Authors: Zhen Wang, Yanting Wei, Hao Zhu, Lingfeng Yu, Jie Zhu, Qixiu Han, Ziying Liu, Jianhao Huang, Yan Zhu, Gentao Fan, Qikai Tang, Ji Qian, Xi Chen and Guangxin Zhou
    Citation: BMC Cancer 2022 22:728
    Content type: Research Published on:

  4. The PD-L1 antibody is an immune checkpoint inhibitor (ICI) attracting attention. The third-generation anticancer drug has been proven to be very effective due to fewer side effects and higher tumor-specific re...

    Authors: Guen Tae Kim, Eun Young Kim, Su-Hyun Shin, Hyowon Lee, Se Hee Lee, Ki-Young Sohn and Jae Wha Kim
    Citation: BMC Cancer 2022 22:727
    Content type: Research Published on:

  5. Ovarian cancer patients require monitoring for relapse. Innovative follow-up methods are increasingly being explored. An electronic patient-reported outcome (ePRO) follow-up pathway was developed for women tre...

    Authors: Fiona Kennedy, Leanne Shearsmith, Marie Holmes, Zoe Rogers, Rob Carter, Uschi Hofmann and Galina Velikova
    Citation: BMC Cancer 2022 22:726
    Content type: Research Published on:

  6. Metastatic soft tissue sarcoma (STS) are a heterogeneous group of malignancies which are not curable with chemotherapy alone. Therefore, understanding the molecular mechanisms of sarcomagenesis and therapy res...

    Authors: Vasileia Tsintari, Bianca Walter, Falko Fend, Mathis Overkamp, Christian Rothermundt, Charles D. Lopez, Marcus M. Schittenhelm and Kerstin M. Kampa-Schittenhelm
    Citation: BMC Cancer 2022 22:725
    Content type: Research Published on:

  8. Small bowel adenocarcinomas (SBAs) are rare and there is little comprehensive data on SBA genomic alterations for Asian patients. This study aimed to profile genomic alterations of SBA in Japanese patients usi...

    Authors: Atsushi Tatsuguchi, Takeshi Yamada, Koji Ueda, Hiroyasu Furuki, Aitoshi Hoshimoto, Takayoshi Nishimoto, Jun Omori, Naohiko Akimoto, Katya Gudis, Shu Tanaka, Shunji Fujimori, Akira Shimizu and Katsuhiko Iwakiri
    Citation: BMC Cancer 2022 22:723
    Content type: Research Published on:

  9. Pomalidomide in combination with dexamethasone has demonstrated positive results in patients with relapsed or refractory multiple myeloma (RRMM), but no data are available in China. We conducted a multicenter,...

    Authors: Wei-Jun Fu, Ya-Fei Wang, Hong-Guo Zhao, Ting Niu, Bai-Jun Fang, Ai-Jun Liao, Hai Bai and Jin Lu
    Citation: BMC Cancer 2022 22:722
    Content type: Research Published on:

  10. Gastric cancer (GC) is one of the most prevalent malignant tumors in Asian countries. Studies have proposed that lncRNAs can be used as diagnostic and prognostic indicators of GC due to the high specificity of...

    Authors: Shuyu Xu, Wenlong Chen, Yiwen Wang, Yuxin Zhang, Rong Xia, Jiemiao Shen, Xing Gong, Yinyin Liang, Jiayi Xu, Hua Tang, Tie Zhao, Yi Zhang, Tao Chen and Chao Wang
    Citation: BMC Cancer 2022 22:721
    Content type: Research Published on:

  11. The 8th edition UICC/AJCC TNM8 (Tumour, Nodes, Metastasis) melanoma staging system introduced several modifications from the 7th edition (TNM7), resulting in changes in survival and subgroup composition. We set o...

    Authors: Matthew C. Hynes, Paul Nguyen, Patti A. Groome, Yuka Asai, Meaghan E. Mavor, Tara D. Baetz and Timothy P. Hanna
    Citation: BMC Cancer 2022 22:720
    Content type: Research Published on:

  12. Ferroptosis is an iron-dependent programmed cell death modality that may have a tumor-suppressive function. Therefore, regulating ferroptosis in tumor cells could serve as a novel therapeutic approach. This ar...

    Authors: Jian Hou, Zhenquan Lu, Xiaobao Cheng, Runan Dong, Yi Jiang, Guoqing Wu, Genyi Qu and Yong Xu
    Citation: BMC Cancer 2022 22:719
    Content type: Research Published on:

  13. Despite advances in surgical techniques, long-term survival after esophagectomy for esophageal cancer remains unacceptably low, and more effective perioperative chemotherapy is expected. However, an important ...

    Authors: Noriyuki Hirahara, Takeshi Matsubara, Shunsuke Kaji, Hikota Hayashi, Koki Kawakami, Yohei Sasaki, Satoshi Takao, Natsuko Takao, Ryoji Hyakudomi, Tetsu Yamamoto and Yoshitsugu Tajima
    Citation: BMC Cancer 2022 22:718
    Content type: Research Published on:

  14. Deletion of 1p is associated with poor prognosis in neuroblastoma, however selected 1p-intact patients still experience poor outcomes. Since mutations of 1p genes may mimic the deleterious effects of chromosom...

    Authors: Chik Hong Kuick, Jia Ying Tan, Deborah Jasmine, Tohari Sumanty, Alvin Y. J. Ng, Byrrappa Venkatesh, Huiyi Chen, Eva Loh, Sudhanshi Jain, Wan Yi Seow, Eileen H. Q. Ng, Derrick W. Q. Lian, Shui Yen Soh, Kenneth T. E. Chang, Zhi Xiong Chen and Amos H. P. Loh
    Citation: BMC Cancer 2022 22:717
    Content type: Research Published on:

  17. To investigate prognostic-related gene signature based on DNA damage repair and tumor microenvironment statue in human papillomavirus 16 negative (HPV16-) head and neck squamous cell carcinoma (HNSCC).

    Authors: Jing Li, Ling-Long Tang and Jun Ma
    Citation: BMC Cancer 2022 22:714
    Content type: Research Published on:

  18. Pituitary tumor transforming gene-1 (PTTG1) transcription factor is identified as carcinogenic and associated with tumor invasiveness, but its role in bladder cancer (BLCA) remains obscure. This research is in...

    Authors: Jian-Di Li, Abdirahman Ahmed Farah, Zhi-Guang Huang, Gao-Qiang Zhai, Rui-Gong Wang, Jia-Lin Liu, Qin-Jie Wang, Guan-Lan Zhang, Zi-Long Lei, Yi-Wu Dang and Sheng-Hua Li
    Citation: BMC Cancer 2022 22:713
    Content type: Research Published on:

  19. CXCL1 belongs to a member of the ELR + CXC chemokine subgroups that also known as GRO-alpha. It has been recognized that several types of human cancers constitutively express CXCL1, which may serve as a crucia...

    Authors: Xiaxia Man, Xiaolin Yang, Zhentong Wei, Yuying Tan, Wanying Li, Hongjuan Jin and Baogang Wang
    Citation: BMC Cancer 2022 22:712
    Content type: Research Published on:

  20. Although early tumor shrinkage (ETS) is a predictor of improved overall survival (OS), the association between ETS and health-related quality of life (HRQOL) remains unclear for patients with metastatic colore...

    Authors: Akira Ooki, Satoshi Morita, Akihito Tsuji, Shigeyoshi Iwamoto, Hiroki Hara, Hiroaki Tanioka, Hironaga Satake, Masato Kataoka, Masahito Kotaka, Yoshinori Kagawa, Masato Nakamura, Tatsushi Shingai, Masashi Ishikawa, Yasuhiro Miyake, Takeshi Suto, Yojiro Hashiguchi…
    Citation: BMC Cancer 2022 22:711
    Content type: Research Published on:

  21. Perioperative chemotherapy (ChT) and preoperative chemoradiation (CRT) are both the standard treatments for locally advanced gastric cancer (LAGC). CRT can achieve a higher pathological complete regression (pC...

    Authors: Menglong Zhou, Wang Yang, Yan Xuan, Wei Zou, Yaqi Wang, Zhiyuan Zhang, Jing Zhang, Miao Mo, Changming Zhou, Yuan Liu, Wenming Zhang, Zhaozhen Zhang, Yiping He, Weiwei Weng, Cong Tan, Lei Wang…
    Citation: BMC Cancer 2022 22:710
    Content type: Study protocol Published on:

  22. With prevalence of hepatocellular carcinoma (HCC) in low-risk population (LRP), establishing a non-invasive diagnostic strategy becomes increasingly urgent to spare unnecessary biopsies in this population. The...

    Authors: Zonglin Xie, Zhenpeng Peng, Yujian Zou, Han Xiao, Bin Li, Qian Zhou, Shuling Chen, Lixia Xu, Jingxian Shen, Yunxian Mo, Sui Peng, Ming Kuang, Jianting Long and Shi-Ting Feng
    Citation: BMC Cancer 2022 22:709
    Content type: Research Published on:

  24. Triple negative breast cancer (TNBC) is a molecular subtype of breast cancer, which is a major health burden of females worldwide. Thymoquinone (TQ), a natural compound, has been found to be effective against ...

    Authors: Md. Asaduzzaman Khan, Meiling Zheng, Jiewen Fu, Mousumi Tania, Jun Li and Junjiang Fu
    Citation: BMC Cancer 2022 22:707
    Content type: Research Published on:

  25. Clinical management of women carrying a germline pathogenic variant (PV) in the BRCA1/2 genes demands for accurate age-dependent estimators of breast cancer (BC) risks, which were found to be affected by a variet...

    Authors: Julika Borde, Yael Laitman, Britta Blümcke, Dieter Niederacher, Konstantin Weber-Lassalle, Christian Sutter, Andreas Rump, Norbert Arnold, Shan Wang-Gohrke, Judit Horváth, Andrea Gehrig, Gunnar Schmidt, Véronique Dutrannoy, Juliane Ramser, Julia Hentschel, Alfons Meindl…
    Citation: BMC Cancer 2022 22:706
    Content type: Research Published on:

  26. Nipple fluid aspiration (NFA) is a technique to acquire nipple aspirate fluid (NAF), which is considered a rich source of breast-specific biomarkers. Originating directly from the mammary ducts, this liquid bi...

    Authors: Susana I. S. Patuleia, Cathy B. Moelans, Jasmijn Koopman, Julia E. C. van Steenhoven, Thijs van Dalen, Carmen C. van der Pol, Agnes Jager, Margreet G. E. M. Ausems, Paul J. van Diest, Elsken van der Wall and Karijn P. M. Suijkerbuijk
    Citation: BMC Cancer 2022 22:705
    Content type: Research Published on:

  27. Parathyroid hormone-related peptide (PTHrP) overexpression and poor patient outcome have been reported for many human tumors, but no studies are available in laryngeal cancer. Therefore, we studied the express...

    Authors: Giovanni Almadori, Antonella Coli, Eugenio De Corso, Dario Antonio Mele, Stefano Settimi, Giovanni Di Cintio, Francesca Brigato, Domenico Scannone, Libero Lauriola and Franco Oreste Ranelletti
    Citation: BMC Cancer 2022 22:704
    Content type: Research Published on:

  28. The mainstay of endometrial cancer treatment is surgical resection of tumors and postoperative adjuvant treatment is recommended if necessary. However, there is no consensus on the management of unresectable m...

    Authors: Hyunji Lim, Seung Hyun Bang, Yeorae Kim, Sang Hyun Cho, Wonkyo Shin, Se Ik Kim, Tae Hun Kim, Dong Hoon Suh, Myong Cheol Lim and Jae-Weon Kim
    Citation: BMC Cancer 2022 22:703
    Content type: Research Published on:

  29. Axillary lymph node (LN) metastasis is one of the most important predictors of recurrence and survival in breast cancer, and accurate assessment of LN involvement is crucial. Determining extent of residual dis...

    Authors: Joana Reis, Joao Boavida, Hang T. Tran, Marianne Lyngra, Laurens Cornelus Reitsma, Hossein Schandiz, Woldegabriel A. Melles, Kjell-Inge Gjesdal, Jürgen Geisler and Jonn Terje Geitung
    Citation: BMC Cancer 2022 22:702
    Content type: Research Published on:

  30. Although isolated central nervous system (CNS) relapses are rare, they may become a serious clinical problem in intensively treated patients with high-risk neuroblastoma (NBL). The aim of this study is the pre...

    Authors: Aleksandra Wieczorek, Joanna Stefanowicz, Marcin Hennig, Elzbieta Adamkiewicz-Drozynska, Marzena Stypinska, Bozenna Dembowska-Baginska, Zuzanna Gamrot, Mariola Woszczyk, Julia Geisler, Tomasz Szczepanski, Szymon Skoczen, Marek Ussowicz, Monika Pogorzala, Szymon Janczar and Walentyna Balwierz
    Citation: BMC Cancer 2022 22:701
    Content type: Research Published on:

  31. Systemic inflammation and insulin resistance (IR) are often associated with poor prognosis in cancer. This study aimed to investigate the prognostic value of surrogate systemic inflammation and IR indices in p...

    Authors: Guo-Tian Ruan, Hai-Lun Xie, Yi-Zhen Gong, Yi-Zhong Ge, Qi Zhang, Zi-Wen Wang, Xi Zhang, He-Yang Zhang, Meng Tang, Meng-Meng Song, Xiao-Wei Zhang, Ming Yang, Yong-Bing Chen, Kai-Ying Yu, Li Deng, Kun-Hua Wang…
    Citation: BMC Cancer 2022 22:700
    Content type: Research Published on:

  32. Tertiary lymphoid structures (TLSs) have been reported to be involved in immune responses in many carcinomas. This study investigated the significance of TLSs in esophageal squamous cell carcinoma, focusing on...

    Authors: Sota Deguchi, Hiroaki Tanaka, Shugo Suzuki, Seji Natsuki, Takuya Mori, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Shigeru Lee, Kazuya Muguruma, Hideki Wanibuchi and Masaichi Ohira
    Citation: BMC Cancer 2022 22:699
    Content type: Research Published on:

  34. Anal squamous cell carcinoma (SCC) generally carries a favorable prognosis, as most tumors are highly sensitive to standard of care chemoradiation. However, outcomes are poor for the 20–30% of patients who are...

    Authors: Daniel R. Principe, Jose L. Cataneo, Kaytlin E. Timbers, Regina M. Koch, Klara Valyi-Nagy, Anders Mellgren, Ajay Rana and Gerald Gantt
    Citation: BMC Cancer 2022 22:697
    Content type: Research Published on:

  35. Esophageal microbiota may influence esophageal squamous cell carcinoma (ESCC) pathobiology. Therefore, we investigated the characteristics and interplay of the esophageal microbiota in ESCC.

    Authors: Zheng Lin, Wenqing Rao, Zhisheng Xiang, Qiaoyan Zeng, Shuang Liu, Kaili Yu, Jinsong Zhou, Jianwen Wang, Weilin Chen, Yuanmei Chen, Xiane Peng and Zhijian Hu
    Citation: BMC Cancer 2022 22:696
    Content type: Research Published on:

  36. The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear.

    Authors: Katharina Nimptsch, Krasimira Aleksandrova, Veronika Fedirko, Mazda Jenab, Marc J. Gunter, Peter D. Siersema, Kana Wu, Verena Katzke, Rudolf Kaaks, Salvatore Panico, Domenico Palli, Anne M May, Sabina Sieri, Bas Bueno-de-Mesquita, Karina Standahl, Maria-Jose Sánchez…
    Citation: BMC Cancer 2022 22:695
    Content type: Research Published on:

  38. Malignant pleural mesothelioma (MPM) is an aggressive and rare tumour with poor prognosis. Most patients are diagnosed with advanced disease and there is a paucity of data on the humanistic burden of MPM in te...

    Authors: Adam Moore, Bryan Bennett, Gavin Taylor-Stokes, Laura McDonald and Melinda J. Daumont
    Citation: BMC Cancer 2022 22:693
    Content type: Research Published on:

  39. Gastric cancer is one of the deadliest cancers, currently available therapies have limited success. Cancer-associated fibroblasts (CAFs) are pivotal cells in the stroma of gastric tumors posing a great risk fo...

    Authors: Cemre Ucaryilmaz Metin and Gulnihal Ozcan
    Citation: BMC Cancer 2022 22:692
    Content type: Research Published on:

  40. Renal cell carcinoma (RCC) is a third most common tumor of the urinary system. Nowadays, Immunotherapy is a hot topic in the treatment of solid tumors, especially for those tumors with pre-activated immune state.

    Authors: Peng Cao, Ji-Yue Wu, Jian-Dong Zhang, Ze-Jia Sun, Xiang Zheng, Bao-Zhong Yu, Hao-Yuan Cao, Fei-Long Zhang, Zi-Hao Gao and Wei Wang
    Citation: BMC Cancer 2022 22:691
    Content type: Research article Published on:

  41. Nucleolar and spindle-associated protein 1 (NUSAP1) was shown to be involved in cell cycle regulation in cancer. However, its prognostic value and underlying mechanism in ovarian cancer remain unclear.

    Authors: Rui Gou, Mingjun Zheng, Yuexin Hu, Lingling Gao, Shuang Wang, Ouxuan Liu, Xiao Li, Liancheng Zhu, Juanjuan Liu and Bei Lin
    Citation: BMC Cancer 2022 22:690
    Content type: Research article Published on:

  42. The mechanism of long non-coding RNA MIR137HG in human gastric cancer (GC) is currently unknown. In the present study, we aimed to explore the function and mechanism of MIR137HG in gastric cancer.

    Authors: Yantao Du, Yichen Chen, Tao Wu, Xiaodan Fan, Wei Lin and Zhouhua Jiang
    Citation: BMC Cancer 2022 22:689
    Content type: Research Published on:

  43. While often life-saving, treatment for head and neck cancer (HNC) can be debilitating resulting in unplanned hospitalization. Hospitalizations in cancer patients may disrupt treatment and result in poor outcom...

    Authors: Amy L. Shaver, Mary E. Platek, Anurag K. Singh, Sung Jun Ma, Mark Farrugia, Gregory Wilding, Andrew D. Ray, Heather M. Ochs-Balcom and Katia Noyes
    Citation: BMC Cancer 2022 22:688
    Content type: Research Published on:

  44. Patients with lung adenocarcinoma (LUAD) may be more predisposed to coronavirus disease 2019 (COVID-19) and have a poorer prognosis. Currently, there is still a lack of effective anti-LUAD/COVID-19 drugs. Thus...

    Authors: Kun Zhang, Ke Wang, Chaoguo Zhang, Xiuli Teng, Dan Li and Mingwei Chen
    Citation: BMC Cancer 2022 22:687
    Content type: Research Published on:

  45. The majority of lung cancer(LC) patients are diagnosed at advanced stage with a poor prognosis. However, there is still no ideal diagnostic and prognostic prediction model for lung cancer.

    Authors: Jingmin Yuan, Yan Sun, Ke Wang, Zhiyi Wang, Duo Li, Meng Fan, Xiang Bu, Jun Chen, Zhiquan Wu, Hui Geng, Jiamei Wu, Ying Xu, Mingwei Chen and Hui Ren
    Citation: BMC Cancer 2022 22:686
    Content type: Research Published on:

  47. In hepatocellular carcinoma (HCC), pulmonary metastasis (PM) after hepatectomy is associated with poor clinical outcomes. The crucial phases of tumour cell proliferation, angiogenesis, and metastasis all entai...

    Authors: Wen-juan Huang, Guang-yu Wang, Zeng-yao Liu, Meng-lin Zhang, Wen Wang, Xin Zhang and Rui-tao Wang
    Citation: BMC Cancer 2022 22:683
    Content type: Research article Published on:

  48. Radiotherapy using the deep inspiration breath-hold (DIBH) technique compared with free breathing (FB) can achieve substantial reduction of heart and lung doses in left-sided breast cancer cases. The anatomica...

    Authors: Jule Wolf, Steffen Kurz, Thomas Rothe, Marco Serpa, Jutta Scholber, Thalia Erbes, Eleni Gkika, Dimos Baltas, Vivek Verma, David Krug, Ingolf Juhasz-Böss, Anca-Ligia Grosu, Nils H. Nicolay and Tanja Sprave
    Citation: BMC Cancer 2022 22:682
    Content type: Research Published on:

  50. Experimental studies indicate that neuroendocrine pathways might play a role in progression of breast cancer. We aim to test the hypothesis that somatic mutations in the genes of neuroendocrine pathways influe...

    Authors: Kejia Hu, Chengshi Wang, Chuanxu Luo, Hong Zheng, Huan Song, Jacob Bergstedt, Katja Fall, Ting Luo, Kamila Czene, Unnur A. Valdimarsdóttir, Fang Fang and Donghao Lu
    Citation: BMC Cancer 2022 22:680
    Content type: Research Published on:

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