Liposarcoma (LPS) is a tumor derived from adipose tissue, and has the highest incidence among soft tissue sarcomas. Dedifferentiated liposarcoma (DDLPS) is a malignant tumor with poor prognosis. Recurrence and...
Authors: Eun Byeol Jo, Young Sang Lee, Hyunjoo Lee, Jae Berm Park, Hyojun Park, Yoon-La Choi, Doopyo Hong and Sung Joo Kim
Breast cancer ranks first in women, and is the second cause of death in this gender. In addition to genetics, the environment contributes to the development of the disease, although the factors involved are no...
Authors: Julio Plaza-Díaz, Ana I. Álvarez-Mercado, Carmen M Ruiz-Marín, Iris Reina-Pérez, Alejandro J. Pérez-Alonso, María Belén Sánchez-Andujar, Pablo Torné, Tania Gallart-Aragón, María Teresa Sánchez-Barrón, Saturnino Reyes Lartategui, Federico García, Natalia Chueca, Ana Moreno-Delgado, Katia Torres-Martínez, María José Sáez-Lara, Cándido Robles-Sánchez…
10–20% of patients with gastric cancer (GC) have HER2+ tumors. Addition of trastuzumab (T) to cisplatin/fluoropyrimidine-based chemotherapy (CT) improved survival in metastatic, HER2+ GC. When pertuzumab (P) w...
Authors: Anna Dorothea Wagner, Heike I. Grabsch, Murielle Mauer, Sandrine Marreaud, Carmela Caballero, Peter Thuss-Patience, Lothar Mueller, Annelie Elme, Markus Hermann Moehler, Uwe Martens, Yoon-Koo Kang, Sun Young Rha, Annemieke Cats, Masanori Tokunaga and Florian Lordick
Telomere genetics has recently been emerged as an important field in molecular oncology. Various genome-wide association studies in different population groups have revealed that polymorphisms in Telomere main...
Following publication of the original article [1], the authors reported that an error in the Methods/Design, Study design and objectives section (third sentence).
Eukaryotic Initiation Factor 4E-Binding Protein (EIF4EBP1, 4EBP1) is overexpressed in many human cancers including breast cancer, yet the role of 4EBP1 in breast cancer remains understudied. Despite the known rol...
Authors: Alexandria C. Rutkovsky, Elizabeth S. Yeh, Stephen T. Guest, Victoria J. Findlay, Robin C. Muise-Helmericks, Kent Armeson and Stephen P. Ethier
The traditional pathologic grading for human renal cell carcinoma (RCC) has low concordance between biopsy and surgical specimen. There is a need to investigate adjunctive pathology technique that does not rel...
Authors: Sara L. Best, Yuming Liu, Adib Keikhosravi, Cole R. Drifka, Kaitlin M. Woo, Guneet S. Mehta, Marie Altwegg, Terra N. Thimm, Matthew Houlihan, Jeremy S. Bredfeldt, E. Jason Abel, Wei Huang and Kevin W. Eliceiri
Sunitinib and pazopanib are extensively used as first-line treatment of metastatic renal cell carcinoma (mRCC). We performed this meta-analysis to assess the anti-tumor effectiveness, toxicity, and total costs...
Following curative-intent neoadjuvant therapy in locally advanced rectal cancer, metastatic progression is still dominant. We investigated if patients’ circulating 25-hydroxyvitamin D [25(OH)D] levels were ass...
Authors: Hanna Abrahamsson, Alina C. Porojnicu, Jonas C. Lindstrøm, Svein Dueland, Kjersti Flatmark, Knut H. Hole, Therese Seierstad, Johan Moan, Kathrine Røe Redalen, Sebastian Meltzer and Anne Hansen Ree
Testosterone suppression is the standard treatment for advanced prostate cancer, and it is associated with side-effects that impair patients’ quality of life, like sexual dysfunction, osteoporosis, weight gain...
Authors: Gustavo Werutsky, Fernando Cotait Maluf, Eduardo Henrique Cronemberger, Vinicius Carrera Souza, Suelen Patricia dos Santos Martins, Fábio Peixoto, Oren Smaletz, Fábio Schutz, Daniel Herchenhorn, Telma Santos, Flavio Mavignier Carcano, David Queiroz Muniz, Paulo R. S. Nunes Filho, Facundo Zaffaroni, Carlos Barrios and André Fay
Following publication of the original article [1], the authors reported that the incorrect Fig. 2A was published in the article. The recovery times required to achieve a normal neutrophil count was omitted. Th...
Authors: Mengqi Jin, Yongxian Hu, Wenjun Wu, Yi Luo, Yamin Tan, Jian Yu, Aiyun Jin, Luxin Yang, He Huang and Guoqing Wei
We investigated the role of the ETS-1 transcription factor in Head and Neck Squamous Cell Carcinoma (HNSCC) in multiple cisplatin-resistant HNSCC cell lines.
Authors: Zejia Yang, Jipei Liao, Brandon A. Carter-Cooper, Rena G. Lapidus, Kevin J. Cullen and Hancai Dan
Metastases account for 90% of all cancer-related deaths, becoming a therapeutic problem. Approximately 50% of all uveal melanoma (UM) patients will develop metastases, mainly in the liver. Post-mortem analyses of...
Authors: Nyasia M. Jones, Hua Yang, Qing Zhang, Vanessa M. Morales-Tirado and Hans E. Grossniklaus
The relationship between polymorphisms in vascular endothelial growth factor (VEGF) and gastric cancer is still inconclusive. We investigated whether there is an association between VEGF genetic polymorphisms ...
Authors: Yeon-Ji Kim, Woo Chul/ Chung, Kyong-Hwa Jun and Hyung-Min Chin
We compared the survival outcomes and acute toxicities of weekly and triweekly cisplatin regimens during concurrent chemoradiotherapy (CCRT) in nasopharyngeal carcinoma (NPC) patients.
Authors: Kailin Wang, Jun Dong, Shasha He, Xia Wang, Chang Jiang, Pili Hu, Jiangui Guo, Xiuyu Cai and Xicheng Wang
Laparoscopic-assisted pylorus-preserving gastrectomy (LAPPG) is a minimally invasive function-preserving surgery for early gastric cancer. This study was designed to investigate the clinical outcomes between L...
Authors: Xiang Xia, Jia Xu, Chunchao Zhu, Hui Cao, Fengrong Yu and Gang Zhao
Recent studies have extensively investigated the role of miRNAs in colorectal cancer (CRC), and several associations have been reported. In addition, single nucleotide polymorphisms (SNPs) in promoter regions ...
Authors: Eun-Gyo Kim, Jung Oh Kim, Han Sung Park, Chang Soo Ryu, Jisu Oh, Hak Hoon Jun, Jong Woo Kim and Nam Keun Kim
Vitronectin is a multifunctional glycoprotein known in several human tumors for its adhesive role in processes such as cell growth, angiogenesis and metastasis. In this study, we examined vitronectin expressio...
Authors: Rebeca Burgos-Panadero, Inmaculada Noguera, Adela Cañete, Samuel Navarro and Rosa Noguera
There were few reports of postoperative radiotherapy (PORT) in stage pIII-N2 Non-small-cell Lung Cancer (NSCLC) patients receiving pneumonectomy followed by adjuvant chemotherapy. This study aims to evaluate s...
Authors: Wenhui Wang, Yu Men, Jianyang Wang, Zongmei Zhou, Dongfu Chen, Zefen Xiao, Qinfu Feng, Jima Lv, Jun Liang, Nan Bi, Shu Geng Gao, Luhua Wang and Zhouguang Hui
Previous studies examining the relationship between hepatitis B virus (HBV) infection and non-Hodgkin lymphoma (NHL) show inconsistent results in different endemic areas. Furthermore, studies evaluating the as...
Authors: Xi Zhou, Huaxiong Pan, Peng Yang, Pian Ye, Haiyan Cao and Hao Zhou
Distant metastasis (DM) is a common treatment failure pattern in acinic cell carcinoma (AciCC) of the major salivary glands; therefore, the main goal of this study was to analyse the predictors of DM in paroti...
Authors: Qigen Fang, Junfu Wu, Wei Du and Xu Zhang
Radiation therapy is a standard form of treating non-small cell lung cancer, however, local recurrence is a major issue with this type of treatment. A better understanding of the metabolic response to radiatio...
Authors: Samantha J. Van Nest, Leah M. Nicholson, Nils Pavey, Mathew N. Hindi, Alexandre G. Brolo, Andrew Jirasek and Julian J. Lum
There are limited effective drugs that can reach the brain to target brain tumors, in particular glioblastoma, which is one of the most difficult cancers to be cured from. Because the overexpression of the sig...
Authors: Chia-Chi Liu, Ching-Fang Yu, Shu-Chi Wang, Hsueh-Yin Li, Chiu-Min Lin, Hsia-Han Wang, Carmen Abate and Chi-Shiun Chiang
Breast cancer (BC) is the most common type of cancer in women worldwide. Post-treatment, patients suffer from side effects and have various rehabilitation needs, which means that individualization is fundament...
Authors: U. Olsson Möller, I. Beck, L. Rydén and M. Malmström
Transformation of chronic lymphocytic leukaemia (CLL) to diffuse large B-cell lymphoma (DLCBL) type Richter’s syndrome (RS) carries a dismal prognosis. Standard-of-care chemoimmunotherapy for de novo RS is ina...
Authors: Niamh Appleby, Toby A. Eyre, Maite Cabes, Aimee Jackson, Rebecca Boucher, Francesca Yates, Sonia Fox, Andrew Rawstron, Peter Hillmen and Anna Schuh
To explore prognostic value of the pre-treatment primary lesion apparent diffusion coefficient (ADC) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC).
Breast cancer screening mammography is widespread in industrialised countries within the framework of public health program or opportunist form. Only few data exist on the comparison of effectiveness between o...
Authors: Sarah Peisl, Stefan Zimmermann, Bertrand Camey, Daniel Betticher and Christine Bouchardy
Only a few patients with pancreatic ductal adenocarcinoma (PDAC) recurring after curative resection and peri-operative (neoadjuvant and adjuvant) therapy are included in clinical trials of metastatic PDAC. As ...
Authors: Olumide B. Gbolahan, Yan Tong, Amikar Sehdev, Bert O’Neil and Safi Shahda
The optimal surgical margins assessment is capital in oral squamous cell carcinoma (OSCC) management. We evaluated the clinical benefits of integrating intraoperative macroscopic margin (MM) assessment and nar...
Authors: Alessandro Baj, Nicola Fusco, Alessandro Bolzoni, Daniela Carioli, Camilla Mazzucato, Alice Faversani, Lorenzo Bresciani, Marco Maggioni and Pasquale Capaccio
The prevalence and factors associated with major depressive disorder (MDD) among adults with cancer have been documented in the scientific literature. However, this data is limited among children and adolescen...
Authors: Benedict Akimana, Catherine Abbo, Joyce Balagadde-Kambugu and Etheldreda Nakimuli-Mpungu
Gene variants are dependable and sensitive biomarkers for target-specific therapies in breast cancer (BC). However, detection of mutations within tissues has many limitations. Plasma circulating free DNA (cfDN...
Authors: Xin Yang, Kuo Zhang, Caiji Zhang, Rongxue Peng and Chengming Sun
To explore imaging biomarkers that can be used for diagnosis and prediction of pathologic stage in non-small cell lung cancer (NSCLC) using multiple machine learning algorithms based on CT image feature analysis.
Authors: Lingming Yu, Guangyu Tao, Lei Zhu, Gang Wang, Ziming Li, Jianding Ye and Qunhui Chen
Patients undergoing major cancer surgery frequently require post-acute care for complications and adverse effects. Enhanced recovery after surgery programmes mean that patients are increasingly discharged home...
Authors: Kerry N. L. Avery, Hollie S. Richards, Amanda Portal, Trudy Reed, Ruth Harding, Robert Carter, Leon Bamforth, Kate Absolom, Elaine O’Connell Francischetto, Galina Velikova and Jane M. Blazeby
Blended cognitive behaviour therapy (bCBT) is an effective treatment for fear of cancer recurrence (FCR) in curatively-treated breast, colorectal and prostate cancer survivors with high FCR. However, long-term...
Authors: Rens Burm, Belinda Thewes, Laura Rodwell, Wietske Kievit, Anne Speckens, Marieke van de Wal and Judith Prins
We investigated the risk of thyroid disorders, namely hypothyroidism, thyrotoxicosis and thyroiditis, in head and neck cancer patients undergoing multimodal treatment.
Authors: Chien-Liang Lin, Shang-Yin Wu, Wen-Tsung Huang, Yin-Hsun Feng, Ching-Yi Yiu, Wei-Fan Chiang, Sheng-Yow Ho and Sheng-Hsiang Lin
Preclinical studies suggest synergistic effectiveness of ascorbic acid (AA, vitamin C) and cytotoxic agents in gastrointestinal malignancies. This phase 1 study aimed to establish the maximum tolerated dose (M...
Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatm...
Authors: Qingwei Li, Xuejun Xu, Dan Su, Tianshuo Zhou, Guangyu Wang and Zhiwei Li
Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK) is a web application focused on improving symptom control. It enables pediatric cancer and hematopoietic stem cell transplant (HS...
Authors: Emily Vettese, Sadie Cook, Dilip Soman, Susan Kuczynski, Brenda Spiegler, Hailey Davis, Nathan Duong, Tal Schechter, L. Lee Dupuis and Lillian Sung
In the past decade, systematic and comprehensive analyses of cancer genomes have identified cancer driver genes and revealed unprecedented insight into the molecular mechanisms underlying the initiation and pr...
Authors: Arne Van Hoeck, Niels H. Tjoonk, Ruben van Boxtel and Edwin Cuppen
Purpose of this study was to analyze whether preoperative maximum standardized uptake value (SUVmax) and carbohydrate antigen 19–9 (CA19–9) levels might provide prognostic information in Chinese patients with ...
Authors: Xinjin Gu, Ruiquan Zhou, Chenggang Li, Rong Liu, Zhiming Zhao, Yuanxing Gao and Yong Xu
Wolf-Hirschhorn syndrome candidate gene-1 (WHSC1), a histone methyltransferase, has been found to be upregulated and its expression to be correlated with expression of enhancer of zeste homolog 2 (EZH2) in sev...
Major vault protein (MVP) is the major component of vault, a eukaryotic organelle involved in multiple cellular processes, and is important in multiple cellular processes and diseases including the drug resist...
Authors: Hui Bai, Chenchen Wang, Yu Qi, Jin Xu, Nan Li, Lili Chen, Bin Jiang, Xudong Zhu, Hanwen Zhang, Xiaoyu Li, Qing Yang, Junqing Ma, Yong Xu, Jingjing Ben and Qi Chen
Helicobacter pylori infection is recognized as the main risk factor for gastric cancer (GC), the fifth most common neoplasia worldwide. H. pylori interacts with the immune system, disrupting the cytokine network ...
Authors: Cecilia Martínez-Campos, Kirvis Torres-Poveda, Margarita Camorlinga-Ponce, Lourdes Flores-Luna, Carmen Maldonado-Bernal, Vicente Madrid-Marina and Javier Torres
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies and is not a clinically homogeneous disease, but subsets of patients with distinct prognosis and response to therapy can be identi...
Authors: Maria Cristina Curia, Fabiana Fantini, Rossano Lattanzio, Francesca Tavano, Francesco Di Mola, Mauro Piantelli, Pasquale Battista, Pierluigi Di Sebastiano and Alessandro Cama
Treatment of solid malignancies has been revolutionized with the introduction of immune checkpoint inhibitors (ICIs) and their use is being expanded in therapy of different cancers. However, immune related adv...
Authors: Karam Khaddour, Veerpal Singh and Maryna Shayuk
Matrix metalloproteinase 19 (MMP19) is a member of zinc-dependent endopeptidases, which have been involved in various physiological and pathological processes. Its expression has been demonstrated in some type...
Authors: Zaiping Chen, Guiyang Wu, Fubo Ye, Guoping Chen, Qinghao Fan, Hao Dong, Xiongwen Zhu and Chongshan Wu
TIMP-2 gene plays an important role in the development of breast cancer. The present study was conducted to evaluate whether TIMP-2 gene polymorphisms are associated with breast cancer risk in a Han Chinese cohor...
Authors: Kai Wang, Guanying Wang, Shangke Huang, Anqi Luo, Xin Jing, Gang Li, Yi Zhou and Xinhan Zhao
Selection of the best lymph node for dissection is a controversial topic in clinical stage-I non-small cell lung cancer (NSCLC). Here, we sought to identify the clinicopathologic predictors of regional lymph n...
Authors: Fei Zhao, Fu-Xi Zhen, Yue Zhou, Chen-Jun Huang, Yue Yu, Jun Li, Qi-Fan Li, Cheng-Xiang Zhu, Xiao-Yu Yang, Shu-Hui You, Qian-Ge Wu, Xue-Yun Qin, Yi Liu, Liang Chen and Wei Wang
