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  1. Content type: Study protocol

    Seroma formation is a common complication after mastectomy and is associated with delayed wound healing, infection, skin flap necrosis, patient discomfort and repeated visits to the out patient clinic to deal ...

    Authors: J. van Bastelaar, R. Granzier, L. M. van Roozendaal, G. Beets, C. D. Dirksen and Y. Vissers

    Citation: BMC Cancer 2018 18:830

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  2. Content type: Research article

    Neck dissection is standard in surgical management of oral squamous cell carcinomas (oscc). However, the immunologic link between primary tumor and lymph nodes is insufficiently understood. Galectin 3 (Gal3) p...

    Authors: Falk Wehrhan, Maike Büttner-Herold, Luitpold Distel, Jutta Ries, Patrick Moebius, Raimund Preidl, Carol I. Geppert, Friedrich W. Neukam, Marco Kesting and Manuel Weber

    Citation: BMC Cancer 2018 18:823

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  3. Content type: Technical advance

    Gene fusion events resulting from chromosomal rearrangements play an important role in initiation of lung adenocarcinoma. The recent association of four oncogenic driver genes, ALK, ROS1, RET, and NTRK1, as lung ...

    Authors: Cecily P. Vaughn, José Luis Costa, Harriet E. Feilotter, Rosella Petraroli, Varun Bagai, Anna Maria Rachiglio, Federica Zito Marino, Bastiaan Tops, Henriette M. Kurth, Kazuko Sakai, Andrea Mafficini, Roy R. L. Bastien, Anne Reiman, Delphine Le Corre, Alexander Boag, Susan Crocker…

    Citation: BMC Cancer 2018 18:828

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  4. Content type: Research article

    Gastrin is an important gastrointestinal hormone produced primarily by G-cells in the antrum of the stomach. It normally regulates gastric acid secretion and is implicated in a number of human disease states, ...

    Authors: Li-Li Meng, Jing-Long Wang, Shu-Ping Xu, Li-Dong Zu, Zhao-Wen Yan, Jian-Bing Zhang, Ya-Qin Han and Guo-Hui Fu

    Citation: BMC Cancer 2018 18:824

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  5. Content type: Research article

    Practical and reliable genotyping procedures with a considerable number of samples are required not only for risk-adapted therapeutic strategies, but also for stratifying patients into future clinical trials f...

    Authors: Tomoya Yokota, Masakuni Serizawa, Ayumu Hosokawa, Kimihide Kusafuka, Keita Mori, Toshiro Sugiyama, Yasuhiro Tsubosa and Yasuhiro Koh

    Citation: BMC Cancer 2018 18:826

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  6. Content type: Research article

    Core needle biopsy (CNB) is a standard diagnostic procedure in the setting of breast cancer screening. However, CNB may result in the borderline diagnoses of lesion of uncertain malignant potential (B3). The a...

    Authors: Christiane Richter-Ehrenstein, Katharina Maak, Sonja Röger and Tilman Ehrenstein

    Citation: BMC Cancer 2018 18:829

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  7. Content type: Case report

    Pneumatosis intestinalis (PI) is a rare complication of chemotherapy, characterized by multiple gas accumulations within the bowel wall.

    Authors: Hironori Uruga, Shuhei Moriguchi, Yui Takahashi, Kazumasa Ogawa, Kyoko Murase, Sayaka Mochizuki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa and Kazuma Kishi

    Citation: BMC Cancer 2018 18:825

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  8. Content type: Study protocol

    Radiofrequency ablation (RFA) and microwave ablation (MWA) are widely accepted techniques to eliminate small unresectable colorectal liver metastases (CRLM). Although previous studies labelled thermal ablation...

    Authors: Robbert S. Puijk, Alette H. Ruarus, Laurien G. P. H. Vroomen, Aukje A. J. M. van Tilborg, Hester J. Scheffer, Karin Nielsen, Marcus C. de Jong, Jan J. J. de Vries, Babs M. Zonderhuis, Hasan H. Eker, Geert Kazemier, Henk Verheul, Bram B. van der Meijs, Laura van Dam, Natasha Sorgedrager, Veerle M. H. Coupé…

    Citation: BMC Cancer 2018 18:821

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  9. Content type: Research article

    Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS...

    Authors: Seyed Hamidreza Mahmoudpour, Obul Reddy Bandapalli, Miguel Inácio da Silva Filho, Chiara Campo, Kari Hemminki, Hartmut Goldschmidt, Maximilian Merz and Asta Försti

    Citation: BMC Cancer 2018 18:820

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  10. Content type: Research article

    Colorectal cancer (CRC) remains a leading cause of death worldwide. Utilizing cisplatin in CRC is correlated with severe adverse effects and drug-resistance. Combined anticancer drug-treatment, along with, the...

    Authors: Mona M. Saber, Abdulaziz M. Al-mahallawi, Noha N. Nassar, Björn Stork and Samia A. Shouman

    Citation: BMC Cancer 2018 18:822

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  11. Content type: Research article

    Hypoxia is a hallmark of the solid tumor microenvironment and is associated with poor outcomes in cancer patients. The present study was performed to investigate mechanisms underlying the hypoxia-induced pheno...

    Authors: Myung-Chul Kim, Sung-Hyun Hwang, Na-Yon Kim, Hong-Seok Lee, Sumin Ji, Yeseul Yang and Yongbaek Kim

    Citation: BMC Cancer 2018 18:819

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  12. Content type: Research article

    The function of hornerin (HRNR), a member of the S100 protein family, is poorly clarified in the development of human tumors. The role of HRNR in hepatocellular carcinoma (HCC) progression is investigated in t...

    Authors: Shun-Jun Fu, Shun-Li Shen, Shao-Qiang Li, Yun-Peng Hua, Wen-Jie Hu, BeiChu Guo and Bao-Gang Peng

    Citation: BMC Cancer 2018 18:815

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  13. Content type: Research article

    The present study aimed to investigate the role of blood supply in early tumorigenesis in colorectal cancer. We leveraged the renin angiotensin system (RAS) to alter colonic blood supply and determine the effe...

    Authors: Sarah Ruderman, Adam Eshein, Vesta Valuckaite, Urszula Dougherty, Anas Almoghrabi, Andrew Gomes, Ajaypal Singh, Baldeep Pabla, Hemant K. Roy, John Hart, Marc Bissonnette, Vani Konda and Vadim Backman

    Citation: BMC Cancer 2018 18:814

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  14. Content type: Research article

    The irinotecan-induced phosphokinome changes in colorectal cancer (CRC) cells were used to guide the selection of targeted agents to be tested in combination with irinotecan.

    Authors: Diego Tosi, Esther Pérez-Gracia, Salima Atis, Nadia Vié, Eve Combès, Mélissa Gabanou, Christel Larbouret, Marta Jarlier, Caroline Mollevi, Adeline Torro, Maguy Del Rio, Pierre Martineau and Céline Gongora

    Citation: BMC Cancer 2018 18:812

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  15. Content type: Research article

    To estimate the prognostic value of inflammatory markers in patients with laryngeal squamous cell carcinoma (LSCC).

    Authors: Linyan Chen, Hao Zeng, Jiapeng Yang, Yuqing Lu, Dan Zhang, Jinggan Wang, Chienyun Kuang, Sha Zhu, Manni Wang and Xuelei Ma

    Citation: BMC Cancer 2018 18:816

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  16. Content type: Research article

    Breast cancer is the most common malignancy in women worldwide. Although the endocrine therapy that targets estrogen receptor α (ERα) signaling has been well established as an effective adjuvant treatment for ...

    Authors: Bo Wang, Dongping Li, Rocio Rodriguez-Juarez, Allison Farfus, Quinn Storozynsky, Megan Malach, Emily Carpenter, Jody Filkowski, Anne E. Lykkesfeldt and Olga Kovalchuk

    Citation: BMC Cancer 2018 18:817

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  17. Content type: Research article

    To investigate the performance of quantitative indicators of MRI in early prediction of the response of gastrointestinal stromal tumor (GIST) to targeted therapy in a patient-based study.

    Authors: Lei Tang, Jian Li, Zi-Yu Li, Xiao-Ting Li, Ji-Fang Gong, Jia-Fu Ji, Ying-Shi Sun and Lin Shen

    Citation: BMC Cancer 2018 18:811

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  18. Content type: Research article

    Doxorubicin-based chemotherapy is currently the most frequently used treatment for triple negative breast cancer (TNBC), yet the response rate is not high due to the lack of a biomarker allowing identification...

    Authors: Bray Denard, Sharon Jiang, Yan Peng and Jin Ye

    Citation: BMC Cancer 2018 18:813

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  19. Content type: Research article

    Cervical cancer screening is not recommended for women who underwent hysterectomy with no history of cervical intraepithelial neoplasia (CIN) of grade 2 or higher. We aimed to determine the cervical cancer scr...

    Authors: Ji-Yeon Shin, Kui Son Choi, Mina Suh, Boyoung Park and Jae Kwan Jun

    Citation: BMC Cancer 2018 18:810

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  20. Content type: Research article

    The Musashi (MSI) family of RNA-binding proteins is best known for the role in post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human cancer are associated with up-regulati...

    Authors: Lan Lan, Hao Liu, Amber R. Smith, Carl Appelman, Jia Yu, Sarah Larsen, Rebecca T. Marquez, Xiaoqing Wu, Frank Y. Liu, Philip Gao, Ragul Gowthaman, John Karanicolas, Roberto N. De Guzman, Steven Rogers, Jeffrey Aubé, Kristi L. Neufeld…

    Citation: BMC Cancer 2018 18:809

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  21. Content type: Research article

    There is still a debate regarding whether regimens combining irinotecan with platinum could replace regimens combining etoposide with platinum, as first-line chemotherapy for extensive-stage small cell lung ca...

    Authors: Fei Xu, Xiaoli Ren, Yuan Chen, Qianxia Li, Ruichao Li, Yu Chen and Shu Xia

    Citation: BMC Cancer 2018 18:808

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  22. Content type: Research article

    As stereotactic body radiation therapy (SBRT) has shown to be effective and safe in patients with hepatocellular carcinoma (HCC), the aim of our propensity score matched analysis was to evaluate the efficacy o...

    Authors: Dominik Bettinger, Eleni Gkika, Michael Schultheiss, Nicolas Glaser, Sophie Lange, Lars Maruschke, Nico Buettner, Simon Kirste, Ursula Nestle, Anca-Ligia Grosu, Robert Thimme and Thomas B. Brunner

    Citation: BMC Cancer 2018 18:807

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  23. Content type: Research article

    Molecular analysis of circulating tumour DNA (ctDNA) is becoming increasingly important in clinical treatment decisions. A pilot External Quality Assessment (EQA) scheme for ctDNA analysis was organized by fou...

    Authors: Cleo Keppens, Elisabeth M. C. Dequeker, Simon J. Patton, Nicola Normanno, Francesca Fenizia, Rachel Butler, Melanie Cheetham, Jennifer A. Fairley, Hannah Williams, Jacqueline A. Hall, Ed Schuuring and Zandra C. Deans

    Citation: BMC Cancer 2018 18:804

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  24. Content type: Case report

    Pilocytic astrocytoma is a low-grade central nervous system tumor most commonly seen in children. Dissemination from a primary intracranial tumor along the neuroaxis has been described at both presentation and...

    Authors: Devin McBride, Zaid Aljuboori, Eyas M. Hattab, Richard Downs, Shiao Woo, Brian Williams, Joseph Neimat and Eric Burton

    Citation: BMC Cancer 2018 18:806

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  25. Content type: Research article

    Resistance to chemotherapy drugs (e.g. taxol) has been a major obstacle in successful cancer treatment. In A549 human lung adenocarcinoma, acquired resistance to the first-line chemotherapy taxol has been a cr...

    Authors: Hao Huang, Tian-Tian Tong, Lee-Fong Yau, Cheng-Yu Chen, Jia-Ning Mi, Jing-Rong Wang and Zhi-Hong Jiang

    Citation: BMC Cancer 2018 18:799

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  26. Content type: Research article

    Previous studies have reported that neoadjuvant chemoradiotherapy can downstage the advanced gastric cancer. However, no studies are available on the application of hypo-radiotherapy to neoadjuvant radiotherap...

    Authors: Ning Li, Xin Wang, Yuan Tang, Dongbing Zhao, Yihebali Chi, Lin Yang, Liming Jiang, Jun Jiang, Wenyang Liu, Yu Tang, Hui Fang, Yueping Liu, Yongwen Song, Shulian Wang, Jing Jin and Yexiong Li

    Citation: BMC Cancer 2018 18:803

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  27. Content type: Research article

    With the advent of novel drugs improved overall survival in patients with multiple myeloma, including patients who received up-front autologous stem cell transplantation (ASCT), has been reported from several ...

    Authors: Jon-Magnus Tangen, Geir Erland Tjønnfjord, Nina Gulbrandsen, Tobias Gedde-Dahl, Espen Stormorken, Kristina Anderson, Camilla Dao Vo and Fredrik Hellem Schjesvold

    Citation: BMC Cancer 2018 18:801

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  28. Content type: Case report

    Pulmonary is an uncommon site of extramedullary involvement in multiple myeloma (MM). Diffuse parenchymal amyloidosis as pulmonary manifestation of MM is even rarer. We report a rare case of diffuse parenchyma...

    Authors: Yin Liu, Zhibin Jin, Haiyan Zhang, Yingwei Zhang, Minke Shi, Fanqing Meng, Qi Sun and Hourong Cai

    Citation: BMC Cancer 2018 18:802

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  29. Content type: Research article

    In this retrospective study, data from patients listed in the Korea Central Cancer Registry during 1993–2014 were analysed, to investigate the incidence and survival of second primary cancers (SPCs) after a di...

    Authors: Myong Cheol Lim, Young-Joo Won, Jiwon Lim, Tahereh Salehi, Chong Woo Yoo and Robert E. Bristow

    Citation: BMC Cancer 2018 18:800

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  30. Content type: Research article

    Hormone sensitive lipase (HSL) is a neutral lipase that preferentially catalyzes the hydrolysis of diacylglycerol contributing to triacylglycerol breakdown in the adipose tissue. HSL has been implicated to pla...

    Authors: Mu Xu, Hui-Hua Chang, Xiaoman Jung, Aune Moro, Caroline Ei Ne Chou, Jonathan King, O. Joe Hines, James Sinnett-Smith, Enrique Rozengurt and Guido Eibl

    Citation: BMC Cancer 2018 18:797

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  31. Content type: Research article

    ADAMs (a disintegrin and metalloproteinase) have long been associated with tumor progression. Recent findings indicate that members of the closely related ADAMTS (ADAMs with thrombospondin motifs) family are a...

    Authors: Felix Kordowski, Julia Kolarova, Clemens Schafmayer, Stephan Buch, Torsten Goldmann, Sebastian Marwitz, Christian Kugler, Swetlana Scheufele, Volker Gassling, Christopher G. Németh, Mario Brosch, Jochen Hampe, Ralph Lucius, Christian Röder, Holger Kalthoff, Reiner Siebert…

    Citation: BMC Cancer 2018 18:796

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  32. Content type: Research article

    As we previously reported, the presence of preoperative metabolic syndrome can predict the significant risk of gastric cancer mortality. As a further extension, we evaluated the prediction of three lipid deriv...

    Authors: Dan Hu, Feng Peng, Xiandong Lin, Gang Chen, Binying Liang, Ying Chen, Chao Li, Hejun Zhang, Guohui Fan, Guodong Xu, Yan Xia, Jinxiu Lin, Xiongwei Zheng and Wenquan Niu

    Citation: BMC Cancer 2018 18:785

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  33. Content type: Research article

    CRC is one of the most common malignancies worldwide, and its molecular mechanisms remain unclear. Elevated levels of BAG3 have been reported in various tumors. The present study aimed to explore the expressio...

    Authors: Ning Li, Minghong Chen, Yansha Cao, Hua Li, Jinping Zhao, Zhenhua Zhai, Fu Ren and Keyan Li

    Citation: BMC Cancer 2018 18:793

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  34. Content type: Research article

    Obesity and diabetes are two risk factors for cancer. To evaluate the association of body mass index (BMI) with cancer risk in diabetic patients may improve current understanding of potential mechanisms.

    Authors: Hui-lin Xu, Min-lu Zhang, Yu-jie Yan, Fang Fang, Qi Guo, Dong-li Xu, Zuo-feng Zhang, Fen Zhang, Nai-qing Zhao, Wang-hong Xu and Guo-you Qin

    Citation: BMC Cancer 2018 18:795

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  35. Content type: Study protocol

    After curative-intent surgery for colorectal liver metastases (CRLM), liver recurrence occurs in more than 60% of patients, despite the administration of perioperative or adjuvant chemotherapy. This risk is ev...

    Authors: Diane Goéré, Jean-Pierre Pignon, Maximiliano Gelli, Dominique Elias, Léonor Benhaim, Frédéric Deschamps, Caroline Caramella, Valérie Boige, Michel Ducreux, Thierry de Baere and David Malka

    Citation: BMC Cancer 2018 18:787

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  36. Content type: Study protocol

    Treatments for localized prostate cancer present challenging tradeoffs in the face of uncertain treatment benefits. These options are best weighed in a process of shared decision-making with the patient’s heal...

    Authors: Joel E. Pacyna, Simon Kim, Kathleen Yost, Hillary Sedlacek, Daniel Petereit, Judith Kaur, Bruce Rapkin, Robert Grubb, Electra Paskett, George J. Chang, Jeff Sloan, Ethan Basch, Brittny Major, Paul Novotny, John Taylor, Jan Buckner…

    Citation: BMC Cancer 2018 18:788

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  37. Content type: Research article

    The incidence of oral squamous cell carcinoma (OSCC) continues to increase each year. Clinical examination and biopsy usually detect OSCC at an advanced stage that is difficult to treat, leading to poor progno...

    Authors: C. Puttipanyalears, A. Arayataweegool, K. Chalertpet, P. Rattanachayoto, P. Mahattanasakul, N. Tangjaturonsasme, V. Kerekhanjanarong, A. Mutirangura and N. Kitkumthorn

    Citation: BMC Cancer 2018 18:786

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  38. Content type: Research article

    Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 ex...

    Authors: Tomohiro Kozako, Paolo Mellini, Takeo Ohsugi, Akiyoshi Aikawa, Yu-ichiro Uchida, Shin-ichiro Honda and Takayoshi Suzuki

    Citation: BMC Cancer 2018 18:791

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  39. Content type: Study protocol

    Individual patients differ in their psychological response when receiving a cancer diagnosis, in this case breast cancer. Given the same disease burden, some patients master the situation well, while others ex...

    Authors: Ulrika Axelsson, Lisa Rydén, Per Johnsson, Patrik Edén, Johanna Månsson, Ingalill Rahm Hallberg and Carl A. K. Borrebaeck

    Citation: BMC Cancer 2018 18:789

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  40. Content type: Research article

    Quizartinib, an inhibitor of class III receptor tyrosine kinases (RTKs), is currently in phase 3 development for the treatment of acute myeloid leukemia (AML) bearing internal tandem duplications in the FLT3 gene...

    Authors: Kyriakos P. Papadopoulos, Eytan Ben-Ami, Amita Patnaik, Denise Trone, Jianke Li and George D. Demetri

    Citation: BMC Cancer 2018 18:790

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  41. Content type: Research article

    The advancements in cancer therapy have improved the clinical outcomes of cancer patients in recent decades. However, advanced cancer therapy is expensive and requires good health care systems. For kidney canc...

    Authors: Wen-Wei Sung, Shao-Chuan Wang, Tzuo-Yi Hsieh, Cheng-Ju Ho, Cheng-Yu Huang, Yu-Lin Kao, Wen-Jung Chen and Sung-Lang Chen

    Citation: BMC Cancer 2018 18:792

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  42. Content type: Research article

    Peri-operative inflammation has been extensively highlighted in cancer patients as detrimental. Treatment strategies to improve survival for cancer patients through targeting peri-operative inflammation have y...

    Authors: H. Paul Redmond, Peter M. Neary, Marcel Jinih, Emer O’Connell, Niamh Foley, Rolf W. Pfirrmann, Jiang H. Wang and D. Peter O’Leary

    Citation: BMC Cancer 2018 18:794

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  43. Content type: Research article

    To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib.

    Authors: Lu Yu, Haibo Wang, Darko Milijkovic, Xiaojun Huang and Qian Jiang

    Citation: BMC Cancer 2018 18:782

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  44. Content type: Research article

    Hepatocellular carcinoma (HCC) is among the deadliest cancers due to its heterogeneity, contributing to chemoresistance and recurrence. Cancer stem-like cells (CSCs) are suggested to play an important role in ...

    Authors: Harshul Pandit, Yan Li, Xuanyi Li, Weizhong Zhang, Suping Li and Robert C. G. Martin

    Citation: BMC Cancer 2018 18:783

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  45. Content type: Study protocol

    Early detection of oesophageal cancer improves outcomes; however, the optimal strategy for identifying patients at increased risk from the pre-cancerous lesion Barrett’s oesophagus (BE) is not clear. The Cytos...

    Authors: Judith Offman, Beth Muldrew, Maria O’Donovan, Irene Debiram-Beecham, Francesca Pesola, Irene Kaimi, Samuel G. Smith, Ashley Wilson, Zohrah Khan, Pierre Lao-Sirieix, Benoit Aigret, Fiona M. Walter, Greg Rubin, Steve Morris, Christopher Jackson, Peter Sasieni…

    Citation: BMC Cancer 2018 18:784

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