Figure 3
Time response distribution of cetuximab in relation to blood vessels and regions of hypoxia in A431 xenografts. Left panels show the distribution of cetuximab (blue) in relation to blood vessels (red) and regions of hypoxia (green) in A431 xenografts at (A) 30 min, (B) 4 h and (C) 48 h after i.p. injection of 1.0 mg. In right panels staining intensity due to cetuximab is plotted against distance to the blood vessel in red and distance to region of hypoxia in green. Scale bar = 100 μm.