Skip to main content

Table 1 Patient characteristics and study results

From: Centrosome clustering and cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors

 

Case

Age/Sex

Stage/Grade

S/M

CIS

Modal number Chr 11

CIN index

CGH 11q13

FISH CCND1

Subpop

SC (%)

C size (μm)

AC

MS (%)

Recurrence (months)

Survival

CRD

CIN negative

U-400

45/♂

TaG1

S

-

2

17.64

normal

normal

No

0

0.8

-

0

0

>6 years

No

 

U-114

63/♀

TaG1

S

-

2

20

normal

normal

No

3.8

1.10

-

0

1;(19)

>6 years

No

 

U-408

66/♂

TaG2

S

+

2

20.18

normal

normal

No

0

0.98

-

0

3;(4),(60),(8)

>6 years

No

 

U-814

68/♂

T1G2

M

-

2

23.97

gain

gain

No

1

0.63

-

0

5;(8),(15),(34),(43),(3)

>5 years

No

 

U-373

52/♀

TaG2

M

-

2

25.9

normal

normal

No

0

0.9

-

0

1;(37)

>6 years

No

 

U-906

58/♂

TaG1

S

-

2

25.41

normal

normal

No

1

0.81

-

0

1;(67)

>5 years

No

 

U-433

68/♂

TaG1

S

+

2

28.75

normal

normal

No

?

?

?

?

1;(28)

>6 years

No

Moderate CIN

U-611

54/♂

T1G3

S

+

2

33.7

normal

normal

No

0

2.04

+

0

0

>42 months

No

 

U-443

62/♂

T1G3

S

-

2

34.16

amp

HSR

Yes (3)

0

0.98

-

0

3;(17),(13)*,(34)*

67 months

Yes

 

U-955

48/♂

TaG1

S

-

2

37.91

normal

normal

No

0

0.8

-

0

0

>6 years

No

 

U-089

45/♂

TaG2

S

-

2

43.33

normal

normal

No

5

1.21

+

0

2;(8),(13)

>5 years

No

 

U-150

60/♂

T1G2

S

-

2

43.51

amp

HSR, DM

Yes (2)

21

4.88

+

0

5;(10),(17),(9),(6),(7)

54 months

Yes

 

U-617

67/♂

TaG1

S

-

2

47.5

normal

normal

No

?

?

?

?

2;(9),(11)

>6 years

No

 

U-013

73/♂

T1G2

S

+

2

54.83

normal

normal

No

4

1.06

-

0

0

>41 months

No

 

U-532

51/♂

T1G3

M

+

2

57.14

normal

gain

No

38

0.68

+

7

0

>6 years

No

High CIN

U-076

67/♂

T1G3

M

+

2

60.41

amp

HSR, DM

Yes (2)

20

2.22

+

17

3;(9),(4),(10)

31 months

Yes

 

U-866

40/♂

T1G3

M

+

3

65.68

normal

gain, HSR, DM

Yes (3)

0

5.69

+

0

-

36 months

Yes

 

U-364

73/♂

T1G3

S

-

2

67.61

normal

gain, HSR1, HSR2

Yes (3)

27

2.06

+

17

0

>3 months

No

 

U-183

62/♂

T1G3

M

+

3

70

normal

HSR

No

5

1.18

+

0

0

>6 years

No

 

U-466

71/♂

T1G2

S

-

4

70.66

gain

gain

No

?

?

?

?

1;(14)

>6 years

No

 

U-564

55/♂

T1G2

S

-

2

70.68

loss

gain

No

0

2.01

+

0

2;(10),(3)

>6 years

No

  1. S: single, M: multiple, CIS: carcinoma in situ, CIN index: percentage of cells not displaying the modal copy number for chromosome 11, subpop: presence and number of intratumor subpopulations, defining subpopulation as a group of cells with a distinctive chromosomal alteration (numerical or structural) at a specific area on the tumor, amp: amplification, HSR: homogeneously staining region, HSR1,2: different types of homogeneously staining region, DM: double minute, SC: percentage of cells displaying supernumerary centrosomes (>2 centrosomes), C size: average size of centrosome, AC: presence of abnormal centrosomes (size >2 μm or number >2 in at least 5% of cells), MS: percentage of cells displaying multipolar spindle, *: metastasis, CRD: cancer related death, ?: data not available
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us