Table 3 Univariate and multivariate analysis of factors associated with OR and PFS

Treatment Group

CD3+

0.80 (0.20-3.25)

0.70

0.94 (0.45-1.94)

0.91

CD4+

1.31 (0.32-1.49)

0.36

0.74 (0.35-1.58)

0.41

CD8+

0.86 (0.22-3.58)

0.74

0.84 (0.45-1.72)

0.62

CD56+

7.75 (1.13-42.6)

0.012

2.70 (1.25-5.88)

0.005

CD68+

1.25 (0.79-7.72)

0.55

1.16 (0.55-2.46)

0.69

Foxp3+

0.54 (0.20-3.50)

0.98

0.89 (0.43-1.83)

0.81

K-ras status

WT vs MT

12.81 (2.15-7.7)

0.008

4.36 (1.77-10.7)

0.0007

Control Group

CD3+

0.91 (0.41-4.11)

0.63

0.84 (0.38-3.98)

0.74

CD4+

1.51 (0.61-2.74)

0.54

0.94 (0.52-2.98)

0.52

CD8+

1.32 (0.59-2.42)

0.31

1.20 (0.59-2.31)

0.76

CD56+

1.21 (0.74-2.07)

0.29

1.11 (0.81-1.56)

0.14

CD68+

0.84 (0.58-2.11)

0.36

0.87 (0.44-3.52)

0.27

Foxp3+

0.66 (0.34-1.92)

0.68

0.71 (0.88-1.56)

0.13

MULTIVARIATE ANALYSIS

Variables

OR

PFS

HR (95% CI)

p-value

HR (95%CI)

p-value

1

1

7.05

0.04

2.62

0.0019

(1.49-45.76)

(1.14-6.00)

1

1

11.7

0.013

4.74

0.001

(1.77-8.33)

(1.8-12.3)