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Figure 2 | BMC Cancer

Figure 2

From: Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer

Figure 2

Representative fluorescence microscopy pictures of claudin-3/4 expression in OSPC-ARK-1 and CC-ARK-1 primary chemotherapy resistant ovarian carcinoma cells. Upper panel: Left: OSPC-ARK-1 control cells before exposure to FITC-conjugated CPE peptide. Note the lack of intrinsic fluorescence in the primary ovarian carcinoma. Right: OSPC-ARK-1 cells 30 minutes after the exposure to 10 μg/ml of FITC-conjugated CPE peptide. Note the presence of a punctuate fluorescence pattern on tumor cells suggesting that FITC-conjugated CPE peptide is compartmentalized after entry into tumor cells. Lower panels: CC-ARK-1 control cells before exposure to FITC-conjugated CPE peptide and 30 minutes, 3 and 6 hours, respectively, after the exposure to 10 μg/ml of FITC-conjugated CPE peptide. Note the presence of a punctuate fluorescence pattern on tumor cells suggesting that FITC-conjugated CPE peptide is compartmentalized after entry into tumor cells.

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BMC Cancer

ISSN: 1471-2407

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