Table 1 Breast cancer cases with equivocal HER2 status.
Case | Reason for Referral | HER2 status by array CGH | FIR Value |
|---|---|---|---|
EQ-1 | Equivocal by FISH; Polysomy? | Negative | 1.18 |
EQ-2 | Equivocal by IHC and FISH | Positive | 1.47 |
EQ-3 | Equivocal by IHC and FISH | Positive | 2.36 |
EQ-4 | Equivocal; HER2 polyploidy? | Negative | 1.09 |
EQ-5 | HER2+; HER2/centromere co-amplification? | Positive | 3.06 |
EQ-6 | Equivocal by FISH pericentromeric monosomy? | Negative | 1.23 |
EQ-7 | Equivocal by FISH; aneusomy? | Negative | 1.19 |
EQ-8 | Equivocal by FISH; aneusomy? | Negative | 0.81 |
EQ-9 | Equivocal by FISH; aneusomy? | Negative | 1.00 |
EQ-10 | Equivocal by IHC and FISH | Negative | 0.92 |
EQ-11 | Equivocal by IHC and FISH | Negative | 1.02 |
EQ-12 | HER2+; centromeric amplification? | Positive | 4.23 |
EQ-13 | HER2+ by IHC; polysomy? | Positive (false - by FISH) | 1.35 |
EQ-14 | Equivocal | Negative | 0.81 |
EQ-15 | Equivocal by IHC and FISH | Negative | 1.00 |
EQ-16 | Discordant: IHC 1+, FISH 2.86 | Negative (false + by FISH) | 0.97 |
EQ-17 | 2.7 "interpret with caution due to monosomy 17" | Negative (false + by FISH) | 1.15 |
EQ-18 | Resolve equivocal IHC, FISH, and OncotypeDX® | Positive | 1.67 |
EQ-19 | Equivocal by IHC and FISH | Negative | 0.97 |
EQ-20 | Resolve equivocal IHC, FISH and OncotypeDx® | Positive | 3.70 |