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Table 3 Association of CIMP with clinicopathological parameters

From: Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation

Variables

Grading

CIMP

P*

  

negative n (%)

positive n (%)

 

Age(Years)

≤50

8(22)

28(78)

 
 

> 50

10(34)

19(66)

0.272

Gender

Female

2(33)

4(67)

 
 

Male

16(27)

43(73)

0.666

PVTT

Negative

13(30)

31(70)

 
 

Positive

5(24)

16(76)

0.629

Preoperative AFP level(ng/ml)

≤400

14(40)

21(60)

 
 

> 400

4(13)

26(87)

0.017

Histopathologic grading

Well+moderate

14(30)

33(70)

 
 

Poor

4(22)

14(78)

0.758

Tumor size(cm)

≤5

8(28)

21(72)

 
 

> 5

10(28)

26(72)

0.986

Tumor number

Single

11(48)

12(52)

 
 

Multiple

7(17)

35(83)

0.007

Hangzhou criteria**

Yes

12(43)

16(57)

 
 

No

6(16)

31(84)

0.017

  1. PVTT, portal vein tumor thrombi; AFP, alpha-fetoprotein
  2. ** Apart from the presence of macrovascular invasion, Hangzhou criteria are matched if total tumor diameter ≤ 8 cm, or if, total tumor diameter > 8 cm, with histopathologic grade I/II and AFP ≤ 400 ng/mL [38].
  3. *Pearson's Chi-square test or Fisher's exact test.