| Condition | DEF | CI | ID50 | SF2 | % survival | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | mean | SD |  | mean | SD |  | mean | SD |  | mean | SD |  | mean | SD |
CAL-27 | RT | Â | Â | Â | Â | Â | Â | 1.94 | 0.47 | Â | 48.37 | 9.31 | Â | 100% | 0% |
 | 24 h 50 nM MTA → RT | 1.04 | 0.23 |  | 1.145 | 0.132 |  | 1.97 | 0.45 |  | 49.25 | 9.71 |  | 97% | 11% |
 | 24 h 75 nM MTA → RT | 1.01 | 0.10 |  | 1.260 | 0.270 |  | 1.94 | 0.54 |  | 47.75 | 7.53 |  | 70% | 12% |
 | 24 h 100 nM MTA → RT | 1.04 | 0.03 |  | 1.229 | 0.269 |  | 1.86 | 0.27 |  | 47.34 | 4.31 |  | 57% | 4% |
 | RT → 24 h 50 nM MTA | 0.87 | 0.06 |  | 1.039 | 0.098 |  | 1.86 | 0.46 |  | 46.21 | 9.19 |  | 88% | 4% |
 | RT → 24 h 75 nM MTA | 0.94 | 0.14 |  | 1.023 | 0.063 |  | 1.77 | 0.63 |  | 44.56 | 12.48 |  | 71% | 8% |
 | RT → 24 h 100 nM MTA | 1.00 | 0.24 |  | 1.005 | 0.080 |  | 1.65 | 0.41 |  | 42.40 | 10.00 |  | 59% | 12% |
 | 24 h 50 nM MTA → 24 h → RT | 1.59 | 0.53 | †| 0.915 | 0.063 |  | 1.71 | 0.66 |  | 43.37 | 12.35 |  | 70% | 21% |
 | 24 h 50 nM MTA → 8 h → RT | 1.23 | 0.31 |  | 0.844 | 0.091 | * | 1.55 | 0.58 |  | 39.45 | 12.88 |  | 88% | 4% |
 | 24 h 50 nM MTA → 4 h → RT | 1.12 | 0.24 |  | 0.965 | 0.106 |  | 1.68 | 0.58 |  | 42.34 | 12.02 |  | 90% | 6% |
 | 24 h 50 nM MTA → 1 h → RT | 1.46 | 0.21 | †| 0.932 | 0.073 |  | 1.21 | 0.35 | †| 32.45 | 8.43 | †| 98% | 4% |
A549 | RT | Â | Â | Â | Â | Â | Â | 2.41 | 0.39 | Â | 56.26 | 6.18 | Â | 100% | 0% |
 | 24 h 100 nM MTA → RT | 1.29 | 0.25 |  | 0.698 | 0.079 | ** | 1.77 | 0.36 |  | 45.39 | 7.15 |  | 87% | 11% |
 | 24 h 200 nM MTA → RT | 1.19 | 0.06 |  | 0.855 | 0.197 | * | 2.18 | 0.34 |  | 52.16 | 4.46 |  | 65% | 12% |
 | 24 h 300 nM MTA → RT | 0.97 | 0.23 |  | 0.887 | 0.294 | * | 2.84 | 1.03 |  | 57.46 | 8.70 |  | 52% | 14% |
 | 24 h 500 nM MTA → RT | 0.75 | 0.28 |  | 0.793 | 0.288 | * | 3.83 | 1.56 |  | 62.76 | 10.23 |  | 38% | 13% |
 | RT → 24 h 200 nM MTA | 0.86 | 0.19 |  | 0.996 | 0.124 |  | 2.77 | 0.20 |  | 60.24 | 3.01 |  | 68% | 19% |
 | RT → 24 h 300 nM MTA | 0.80 | 0.10 |  | 0.862 | 0.173 | * | 2.98 | 0.30 |  | 61.48 | 2.65 |  | 52% | 16% |
 | RT → 24 h 500 nM MTA | 0.76 | 0.11 |  | 0.723 | 0.166 | * | 3.11 | 0.19 |  | 62.75 | 1.09 |  | 38% | 15% |
 | 24 h 100 nM MTA → 24 h → RT | 0.98 | 0.15 |  | 0.832 | 0.067 | * | 2.16 | 0.11 |  | 52.70 | 2.00 |  | 84% | 16% |
 | 24 h 100 nM MTA → 8 h → RT | 1.21 | 0.18 |  | 0.731 | 0.129 | * | 2.02 | 0.24 |  | 50.62 | 4.87 |  | 85% | 9% |
 | 24 h 100 nM MTA → 4 h → RT | 1.56 | 0.41 |  | 0.718 | 0.103 | * | 1.63 | 0.35 |  | 42.19 | 6.30 |  | 94% | 10% |
 | 24 h 100 nM MTA → 1 h → RT | 1.52 | 0.39 |  | 0.677 | 0.076 | ** | 1.85 | 0.51 |  | 46.28 | 9.78 |  | 85% | 11% |