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Table 4 Association of IL-10 polymorphisms with PCa aggressiveness

From: Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese

Allele/Haplotype

Early stage (72)

Advanced stage (180)

P

OR (95%CI)

-1082A/G

    

A

124(86.1)

338(93.9)

 

1.00

G

20(13.9)

22(6.1)

0.005*

2.48(1.31~4.70)

-819 C/T

    

T

86(59.7)

249(69.2)

 

1.00

C

58(40.3)

111(30.8)

0.043*

1.51(1.01~2.26)

-592 C/A

    

A

86(59.7)

249(69.2)

 

1.00

C

58(40.3)

111(30.8)

0.043*

1.51(1.01~2.26)

Haplotype

    

ATA

82(56.9)

245(68.1)

 

1.00

ACC

42(29.2)

93(25.8)

0.184

1.35(0.87~2.10)

GTA

4(2.8)

4(1.1)

0.128

2.99(0.73~12.2)

GCC

16(11.1)

18(5.0)

0.008*

2.66(1.30~5.45)

  1. *P < 0.05.