Figure 6From: Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference Bimodal distribution of methylated and unmethylated alleles. Normalized ratio value groups between methylated and unmethylated alleles of the 70 MGMT methylated GBMs identified with our MS-qLNAPCR protocol. There is a bimodal distribution of cases with two prevalent groups showing ratio values between 0.001-0.33 and 0.67-1, respectively.Back to article page