Polymorphisms in regulatory regions of Cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study

Table 4 Impact of clinical and demographic characteristics on the risk of breast cancer in Brazilian women

Characteristic	Category	Cases	Controls	OR	95%CI	P χ2
Age* (years)	< 48	147	163	1
	≥ 48	171	110	1.72	(1.24-2.39)	0.001
Missing data		0	0
Menarche (Age)	< 12	120	93	1
	≥ 12	120	74	1.25	(0.84-1.86)	0.258
Missing data		78	106
Menopause (Age)**	≤ 54	98	62	1
	≥ 55	10	5	0.79	(0.25-2.42)	0.68
Missing data		127	103
First Birth (Age)	≤ 30	161	103	1
	≥ 31 or nulliparous	75	68	1.41	(0.93-2.13)	0.09
Missing data		82	102
Fertile Time¥	< 35	45	35	1
	≥ 35	60	27	1.73	(0.83-3.42)	0.089
Missing data		3	5
Use of contraceptives †	< 2	110	105	1
	≥2	92	59	1.49	(0.97-2.27)	0.065
Missing data		116	109
Use of HRT ^θ	no	79	43	1
	yes	25	20	0.68	(0.32-1.44)	0.276
Missing data		4	4
Use of NSAIDs	no	187	154	1
	yes	31	13	1.96	(0.99-3.88)	0.053
Missing data		100	106
BMI	Underweight: ≤ 18.4	9	1	4.13	(0.50-33.6)	0.28
	Normal: 18.5 - 24.9	98	45	1
	Overweight: ≥ 25.0	159	63	1.15	(0.73-1.83)	0.55
Missing Data		52	164
Smoking Habit	no	174	83	1
	yes	98	38	1.23	(0.77-1.94)	0.42
Missing data		46	152
Color	White	131	120			0.619‡
	Intermediate	125	96
	Black	62	57
Missing data		0	0

* 48 years old is the median of cases + controls; ** Menopausal status: postmenopausal: cases n = 108, controls: n = 67; premenopausal: cases: n = 83, controls n = 103; ¥ Age of Menopause - Age of Menarche (only for women in menopause); † For at least 2 years; ^θHRT: Hormonal Reposition Therapy (only for women in menopause); NSAIDs: Non-Steroidal Anti-Inflammatory Drugs; BMI: Body Mass Index at diagnosis (patients) or at recruitment (controls), BMI = weight (Kg)/height² (m²); OR: Odds Ratio; 95%CI: 95% Confidence Interval; P from Chi-square test (Pearson p-value); ‡ P from Fisher test.

ISSN: 1471-2407