From: The invasive lobular carcinoma as a prototype luminal A breast cancer: A retrospective cohort study
Characteristic | ILC | IDC | P | LA-IDC | P | ||||
---|---|---|---|---|---|---|---|---|---|
(N = 83) | (N = 2833) | (N = 1088) | |||||||
n | % | n | % | n | % | ||||
Mean age (years) | 48.3 ± 8.5 | 48.2 ± 10.5 | 0.93 | 47.9 ± 10.2 | 0.71 | ||||
pT | T1 | 33 | 40.2 | 1730 | 61.2 | 0.001 | 667 | 61.4 | 0.001 |
T2 | 45 | 54.9 | 986 | 34.9 | 373 | 34.4 | |||
T3 | 4 | 4.9 | 89 | 3.1 | 37 | 3.4 | |||
T4 | 0 | 0 | 23 | 0.8 | 9 | 0.8 | |||
Unknown | 1 | 5 | 2 | ||||||
pN | N0 | 46 | 56.1 | 1639 | 58.7 | 0.18 | 551 | 51.5 | 0.25 |
N1 | 24 | 29.3 | 763 | 27.3 | 333 | 31.2 | |||
N2 | 5 | 6.1 | 276 | 9.9 | 128 | 12 | |||
N3 | 7 | 8.5 | 116 | 4.2 | 57 | 5.3 | |||
Unknown | 1 | 39 | 19 | ||||||
M | M0 | 83 | 100 | 2777 | 98 | 0.19 | 1064 | 97.8 | 0.17 |
M1 | 0 | 0 | 56 | 2 | 24 | 2.2 | |||
Stage | I | 25 | 30.1 | 1184 | 41.9 | 0.06 | 426 | 39.3 | 0.15 |
II | 44 | 53 | 1248 | 44.2 | 476 | 44 | |||
III | 14 | 16.9 | 337 | 11.9 | 157 | 14.5 | |||
IV | 0 | 0 | 56 | 2 | 24 | 2.2 | |||
Unknown | 0 | 8 | 5 | ||||||
HG | 1 or 2 | 75 | 90.4 | 1438 | 54.9 | <0.001 | 576 | 57.3 | <0.001 |
3 | 8 | 9.6 | 1183 | 45.1 | 429 | 42.7 | |||
Unknown | 212 | 83 | |||||||
ER | Positive | 75 | 90.4 | 1825 | 64.4 | <0.001 | · | · | · |
Negative | 8 | 9.6 | 1008 | 35.6 | · | · | |||
PgR | Positive | 59 | 71.1 | 1420 | 50.1 | <0.001 | · | · | · |
Negative | 24 | 28.9 | 1413 | 49.9 | · | · | |||
HER2 | Negative | 79 | 97.5 | 1586 | 74.6 | <0.001 | · | · | · |
Positive | 2 | 2.5 | 540 | 25.4 | · | · | |||
Unknown * | 2 | 707 | · | · | |||||
Subtype | Luminal A | 74 | 91.4 | 1088 | 51.2 | <0.001 | · | · | · |
Non-LA | 7 | 8.6 | 1038 | 48.8 | · | · | |||
Unknown | 2 | 707 | · | · | |||||
p53 | 0 or 1+ | 74 | 93.7 | 2146 | 77.7 | 0.001 | 951 | 89.7 | 0.26 |
2+ or 3+ | 5 | 6.3 | 616 | 22.3 | 109 | 10.3 | |||
Unknown | 4 | 71 | 28 | ||||||
Ki-67 | 10.3 ± 10.6 | 20.6 ± 19.8 | <0.001 | 13.5 ± 13.2 | 0.03 | ||||
Operation | BCS | 57 | 68.7 | 2109 | 75.1 | 0.18 | 786 | 73 | 0.39 |
Mastectomy | 26 | 31.3 | 698 | 24.9 | 290 | 27 | |||
None | 0 | 0 | 26 | 3 | |||||
Adjuvant therapy | |||||||||
Chemotherapy | Yes | 68 | 81.9 | 2383 | 84.1 | 0.59 | 922 | 84.7 | 0.49 |
No | 15 | 18.1 | 450 | 15.9 | 166 | 15.3 | |||
Hormone therapy | Yes | 79 | 95.2 | 2113 | 74.6 | <0.001 | 1057 | 97.2 | 0.31 |
No | 4 | 4.8 | 720 | 25.4 | 31 | 2.8 | |||
Anti-HER2 therapy | Yes† | 1 | 1.2 | 164 | 5.8 | 0.08 | · | · | · |
No | 82 | 98.8 | 2669 | 94.2 | · | · | |||
Radiotherapy | Yes | 64 | 77.1 | 2323 | 82 | 0.25 | 879 | 80.8 | 0.41 |
No | 19 | 22.9 | 510 | 18 | 209 | 19.2 |